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Topic: Clinical Characteristics and Health Care Setting
November 17, 2020
Prevalence of IgG Antibodies against the Severe Acute Respiratory Syndrome Coronavirus-2 among Healthcare Workers in Tennessee during May and June 2020
[Pre-print, not peer reviewed] SARS-CoV-2 seroprevalence was low (<1%) among a large cohort of healthcare workers (HCWs) in Tennessee (n=11,787) from May to June 2020, despite sustained community-wide transmission during the same time period. Differences in seroprevalence across facilities reflected the differences in levels of community transmissions, with higher prevalence among HCWs located in urban…
Prolonged Shedding of Severe Acute Respiratory Syndrome Coronavirus 2 in Patients with COVID-19. Emerging Microbes & Infections
In a cohort of “long-term” COVID-19 patients who recovered from acute disease but still shed viral RNA for more than 3 months (n=38), the median shedding duration was 92 days. Fluctuations between positive and negative PCR tests were observed and viral loads were lower than in patients with acute infection. Most participants were elderly people…
SARS-CoV-2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth
In a multicenter study of children hospitalized with COVID-19 in New York, New Jersey, and Connecticut (n=281), over half had respiratory disease and 69/281 (25%) had multi-system inflammatory syndrome in children (MIS-C). Obesity and low blood oxygen levels (hypoxia) on admission predicted severe respiratory disease, while lower absolute lymphocyte count predicted severe MIS-C. Neither race/ethnicity…
Impact of the COVID-19 Pandemic on Invasive Pneumococcal Disease and Risk of Pneumococcal Coinfection with SARS-CoV-2: Prospective National Cohort Study, England
A national cohort study in England found a 30% decline in invasive pneumococcal disease (IPD) incidence across all age groups following COVID-19 lockdowns, similar to other reported reductions in bacterial and viral infections attributable to social distancing measures. Although IPD/COVID-19 co-infections were rare (about 0.025% of SARS-CoV-2 infections), the case fatality rates were much higher…
November 16, 2020
Intrauterine Transmission of SARS-CoV-2
A case of fetal death associated with intrauterine transmission of SARS-CoV-2 was documented in Brazil. SARS-CoV-2 RNA was detected in cotyledon samples, membranes, and umbilical cord blood aspirate, suggesting possible breakdown of the placental barrier. However, all fetal tissue samples tested negative. Examination and autopsy found placental lesions and vascular malperfusions, microglial hyperplasia, and lymphocytic…
Critical Care Workers Have Lower Seroprevalence of SARS-CoV-2 IgG Compared with Non-Patient Facing Staff in First Wave of COVID19
[Pre-print, not peer-reviewed] Loss of smell was a reliable predictor of SARS-CoV-2 seropositivity in a study that screened over 500 healthcare workers at a regional critical care center in the UK. While 45% of participants reported symptoms potentially consistent with COVID-19, the overall seroprevalence was 14%. There was a significant difference in seropositivity between staff…
Newly Reported Studies on the Increase in Gastrointestinal Symptom Prevalence With COVID-19 Infection: A Comprehensive Systematic Review and Meta-Analysis
A systematic review and meta-analysis comparing the frequency of gastrointestinal symptoms among COVID-19 patients from Chinese studies conducted earlier in the epidemic and more recent studies predominantly conducted outside of China found higher rates of diarrhea, nausea/vomiting, and abdominal pain in non-Chinese studies. The pooled prevalence estimate of any GI symptom was 0.21, and the…
Association between COVID-19 Diagnosis and Presenting Chief Complaint from New York City Triage Data
A retrospective analysis of adult emergency department visits from New York City found there may be populations of patients at high risk for COVID-19 who present with atypical complaints and symptoms. While most people who received SARS-CoV-2 testing had a fever, shortness of breath, or a cough, many others who received testing reported symptoms of…
November 13, 2020
Nothing Much Has Changed: COVID‐19 Nursing Home Cases and Deaths Follow Fall Surges
Surges in nursing home-associated SARS-CoV-2 infections occurred in hotspot states during the end of October. Data were collected from 778 facilities in Idaho, Montana, North and South Dakota, Utah, and Wisconsin regarding community spread, testing, and PPE and staffing shortages. Across the six states, weekly cases among staff members tripled from September to October and…
November 12, 2020
Smoking Doubles the Mortality Risk in COVID-19: A Meta-Analysis of Recent Reports and Potential Mechanisms
A systematic review and meta-analysis of 10 studies (n = 11,189 COVID-19 patients) found that smokers had a 2-fold increased risk of mortality compared to non-smokers. There was no difference in mortality risk between current and former smokers. Salah et al. (Oct 7, 2020). Smoking Doubles the Mortality Risk in COVID-19: A Meta-Analysis of Recent…
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