Result for
Topic: Clinical Characteristics and Health Care Setting
November 23, 2020
Workers at Long-Term Care Facilities and Their Risk for Severe COVID-19 Illness
50% of long-term care workers (LTC) in the US are at increased risk of severe illness from COVID-19 due to age >65, obesity, or medical co-morbidities based on data from the 2017 and 2018 National Health Interview Surveys and risk categories developed by the CDC. Severe illness was defined as hospitalization, intubation, or death. A…
Pregnant Women with Severe or Critical COVID-19 Have Increased Composite Morbidity Compared to Non-Pregnant Matched Controls
A case-control study of women hospitalized with severe or critical COVID-19 in New York City and Philadelphia reported that pregnant women (n=38) were more likely to experience severe outcomes, including death and need for intubation or ventilation, when compared to the non-pregnant (n=94) women (34% vs. 15%, aOR=4.6). Pregnant patients also experienced higher rates of…
High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19
In a cohort of 48 university student athletes who recovered from SARS-CoV-2 infection and returned to campus in July 2020 in West Virginia (30% asymptomatic), more than 1 in 3 showed signs of resolving heart inflammation on imaging studies. 27 student athletes (56%) had cardiac abnormalities, including 19 students with late enhancement of the pericardium and…
November 20, 2020
Delirium in Older Patients With COVID-19 Presenting to the Emergency Department
Delirium is a common symptom in older adults diagnosed with COVID-19 in the emergency department (ED). In this cohort study of 817 older ED patients with COVID-19, 28% had delirium at presentation, and delirium was the sixth most common of all presenting symptoms and signs. Among delirious patients, 16% presented with delirium as a primary…
Temporal Associations between Community Incidence of COVID-19 and Nursing Home Outbreaks in Ontario, Canada
[Pre-print, not peer reviewed] In a population-based cohort study of all laboratory-confirmed COVID-19 cases in the Province of Ontario, Canada (population >14-million) between March 1, 2020 and July 16, the average lag time between community cases and nursing home outbreaks was 23 days, with substantial variability across geographic regions ranging from 11 to 43 days….
Pregnancy Outcomes Among Women With and Without Severe Acute Respiratory Syndrome Coronavirus 2 Infection
SARS-CoV-2 infection in pregnancy was not associated with adverse pregnancy outcomes in a cohort of women in Texas. At a large county medical center, adverse pregnancy outcomes were similar in 252 SARS-CoV-2–positive and 3,122 negative pregnant women tested in outpatient and inpatient settings. Neonatal infection occurred in 3% of infants, predominantly among infants born to…
November 19, 2020
Low Incidence of Airborne SARS-CoV-2 in Acute Care Hospital Rooms with Optimized Ventilation
Out of 100 air samples collected over 2 months in acute care hospital rooms hosting COVID-19 patients, 11 samples were confirmed positive via PCR and 0 samples were infectious via viral cultures. No correlation between patient clinical characteristics (e.g., length of hospital stay) and detection of airborne viral RNA was observed. Dumont-Leblond et al. (Nov…
SARS-CoV-2 Viral Load on Admission Is Associated with 30-Day Mortality.
In a retrospective study of 181 patients admitted to UW Medicine hospitals, patients with a high SARS-CoV-2 viral load (Cycle threshold < 22) upon hospital admission had a 4.2-fold increase in odds of 30-day mortality. Meanwhile, those who were IgG seropositive had non-significantly lower odds of mortality (OR 0.43, 95% CI: 0.15-1.26). The authors suggest…
November 18, 2020
Characteristics of Pediatric Multi-System Inflammatory Syndrome (PMIS) Associated with COVID-19: A Meta-Analysis and Insights into Pathogenesis
A meta-analysis of pediatric multisystem inflammation syndrome (PMIS) documented three common types of PMIS clinical presentation: persistent fever and gastrointestinal symptoms, cardiogenic shock, and Kawasaki disease-like syndrome. In 7 studies including 182 patients, only 9% of patients presented with respiratory symptoms and only 37% were positive for SARS-CoV2 by PCR, while 81% were positive for…
Prevalence of SARS-CoV-2 Infection in Previously Undiagnosed Health Care Workers in New Jersey, at the Onset of the U.S. COVID-19 Pandemic
In the early phase of the COVID-19 pandemic, non-ICU healthcare workers had higher rates of SARS-CoV2 when compared to the general population. A cross-sectional study conducted in a university and two affiliated university hospitals in New Jersey found that healthcare workers had a higher rate of SARS-CoV-2 seropositivity when compared to non-healthcare workers (40/546 [7.3%]…
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