Alliance for Pandemic Preparedness

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Topic: Clinical Characteristics and Health Care Setting


November 12, 2020

‘Long-COVID’: A Cross-Sectional Study of Persisting Symptoms, Biomarker and Imaging Abnormalities Following Hospitalisation for COVID-19

Among 384 patients in London followed for an average of 54 days post-discharge from COVID-19 hospitalization, 53% reported persistent breathlessness, 34% cough, 69% fatigue, and 14.6% depression. 38% of chest radiographs remained abnormal and 9% showed signs of worsening. Mandal et al. (Nov 10, 2020). ‘Long-COVID’: A Cross-Sectional Study of Persisting Symptoms, Biomarker and Imaging…


Sixty-Day Outcomes Among Patients Hospitalized With COVID-19

Among 1,648 hospitalized COVID-19 patients in Michigan, 1250 (75.8%) survived and were discharged between March 16 and July 1, with a majority returning home. By 60 days post-discharge, an additional 84 patients died, bringing the overall mortality rate to 29.2% (63.5% among those admitted to ICU). An additional 189 (15.1%) patients were rehospitalized. Among the…


November 10, 2020

Association Between Nursing Home Crowding and COVID-19 Infection and Mortality in Ontario, Canada

Among 618 nursing homes in Canada, those that were crowded were more likely to experience COVID-19 outbreaks with worse outcomes. Nursing homes were classified according to a crowding index defined as themean number of residents per bedroom and bathroom. While the likelihood of SARS-CoV-2 introduction did not differ between homes with a low or high…


November 9, 2020

Characteristics of Hospitalized COVID-19 Patients Discharged and Experiencing Same-Hospital Readmission — United States, March–August 2020

Among 106,543 patients discharged after hospitalization for COVID-19 in the US between March–July 2020, 9,504 (9%) experienced at least one readmission to the same hospital within 2 months of discharge, including 1,667 (2%) who were readmitted more than once. The median interval from discharge to first readmission was 8 days (IQR 3–20 days). Risk factors for…


Validation of Home Oxygen Saturations as a Marker of Clinical Deterioration in Patients with Suspected COVID-19

[Preprint, not peer-reviewed] A retrospective cohort study among 1,080 COVID-19 patients conveyed by ambulance to the hospital in the UK found that oxygen saturation measurements at first point of contact in the community were the most predictive of 30-day COVID-19 mortality or ICU admission, with an area under receiver operator curve (AUROC) of 0.8. This…


Containment of a COVID-19 Outbreak in an Inpatient Geriatric Psychiatry Unit

An inpatient geriatric psychiatry unit in King County, Washington reported a SARS-CoV-2 outbreak between March 11-18, 2020, with 9 inpatients and 7 staff members with confirmed SARS-CoV-2 infection. Enhanced infection prevention interventions and engagement of frontline psychiatric care staff following the outbreak effectively contained the outbreak, with no further patients and only one staff member…


The Prevalence of Asymptomatic and Symptomatic COVID19 Disease in a Cohort of Quarantined Subjects

In a cohort of 2,714 travelers returning to Bahrain by air between February 25th and March 14th, 2020, 136 were SARS-CoV-2 positive on arrival, 68% of whom were asymptomatic. A further 52 became SARS-CoV-2 positive during the mandatory 14-day quarantine following arrival, 46% of whom remained asymptomatic until viral clearance. Al-Qahtani et al. (Nov 2,…


November 6, 2020

Incidence of COVID-19 Virus Transmission in Three Dental Offices: A 6-Month Retrospective Study

There was no evidence for transmission of SARS-CoV2 in dental patients undergoing procedures in New York during a period that included the peak of the pandemic. A prospective study of dental patients (n =2,810) in New York treated in three different dental offices over a 6 months period of March 15-September 15 found that there…


COVID-19 Seropositivity and Asymptomatic Rates in Healthcare Workers Are Associated with Job Function and Masking.

A study of frontline healthcare workers in Michigan found that having direct contact with patients who were positive for SARS-CoV-2 increased the likelihood of seropositivity but masks were protective. Of those who reported direct contact with SARS-CoV-2-infected patients, seropositivity rates were 10% with an N95 mask, 13% with surgical mask, and 18% with no mask. Among…


Viral RNA Level, Serum Antibody Responses, and Transmission Risk in Recovered COVID-19 Patients with Recurrent Positive SARS-CoV-2 RNA Test Results: A Population-Based Observational Cohort Study

Intermittent excretion of low levels of SARS-CoV-2 RNA after hospital discharge was not associated with either secondary transmission or worsening clinical disease. A population-based observational study of patients in China who had clinically recovered from SARS-CoV-2 and satisfied criteria for discharge including two negative PCR tests were then re-tested as outpatients. 479 patients were found…



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