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Topic: Clinical Characteristics and Health Care Setting
September 30, 2020
Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Infection
Among a cohort of hospitalized patients with COVID-19 in the US (n=1685), the risk of death remained significantly greater among patients with a psychiatric disorder after controlling for demographic characteristics, other medical comorbidities, and hospital location. Li et al. (Sept 30, 2020). Association of a Prior Psychiatric Diagnosis With Mortality Among Hospitalized Patients With Coronavirus…
September 29, 2020
Clinical Epidemiology of Hospitalized Patients with COVID-19 in Japan: Report of the COVID-19 REGISTRY JAPAN
An observational study of patients hospitalized with COVID-19 in Japan (n=2,638) found a lower prevalence of comorbidities and a trend toward lower mortality compared to inpatient studies from other countries. Among the study participants, the most common comorbidities were hypertension (15%) and diabetes without complications (14%). In addition, there were twice as many individuals with…
Viral Presence and Immunopathology in Patients with Lethal COVID-19: A Prospective Autopsy Cohort Study
An autopsy study among 21 patients who died of COVID-19 showed widespread systemic inflammation in the lungs, heart, kidney, liver, and brain, with a continued presence of inflammatory neutrophils cells even several weeks into the disease course. The lung was the organ with the most abundant SARS-CoV-2, and extensive inflammation was detected in the brain….
Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2
An analysis of ACE2 expression among 229 individuals indicated that participants who were female (OR=2.3), had hypertension (OR=1.3), had a cardiocerebrovascular disease (OR=1.3), had cancer (OR=1.7), or who were over 60 years old (OR=3.1) had higher levels of ACE2 expression, which is one of the cellular entry receptors for SARS-CoV-2. The authors suggest that persons…
September 28, 2020
Age-Specific COVID-19 Case-Fatality Rate: No Evidence of Changes over Time
Using national-level surveillance data from April to August in Italy, Signorelli and Odone reported the case fatality of COVID-19 varied significantly by age (ranging from 0.1-2.8% in people <60 years up to 29-35% in people ³80 years). However, the age-specific rates were similar over time, as estimated at 2, 4 and 6 months since the onset of…
Racial Disparities in Incidence and Outcomes Among Patients With COVID-19
During 2 weeks in March in Milwaukee, Wisconsin, COVID-19 incidence was higher among Black residents (vs. White: OR=5.4). Adjusting for zip code of residence, Black race (aOR=1.8) and poverty (aOR=3.8) were associated with a greater likelihood of have COVID-19, but only poverty was associated with COVID-19 ICU admission (aOR=3.6). Muñoz-Price et al. (Sept 25, 2020)….
COVID-19 Trends Among School-Aged Children — United States, March 1–September 19, 2020
The incidence of SARS-CoV-2 infection in school-age children increased from March and peaked in July and August, followed by a decline in September. During March 1–September 19, 2020, the US reported a total of 277,285 laboratory-confirmed cases of COVID-19 in school-aged children. The average weekly COVID-19 incidence among adolescents aged 12–17 years was approximately…
Risk Factors Associated with Adverse Fetal Outcomes in Pregnancies Affected by Coronavirus Disease 2019 (COVID-19): A Secondary Analysis of the WAPM Study on COVID-19
The risk of vertical transmission of SARS-CoV-2 was very low in a multinational cohort of 250 neonates born to pregnant women with COVID-19, with only 1 infant (0.4%) testing positive by RT-PCR of pharyngeal swabs performed after delivery. The infant who tested positive was asymptomatic and had a negative RT-PCR test after 14 days of…
September 25, 2020
Early predictors of in-hospital mortality in patients with COVID-19 in a large American cohort
Clinical variables present on admission that were associated with in-hospital death among COVID-19 patients were older age, low oxygen saturation and elevated respiratory rate in a multicenter study. Laboratory measurements associated with in-hospital mortality included markers of renal and hepatic dysfunction and elevated procalcitonin and lactic acid. Bahl et al. (Sept 25, 2020). Early predictors…
Update: Characteristics of Health Care Personnel with COVID-19 — United States, February 12–July 16, 2020
Risk factors for mortality in health care personnel with COVID-19 were older age, male sex, Asian or Black self-identification, or the presence of an underlying comorbidity. Data from 100,570 laboratory confirmed and probable COVID-19 cases reported to CDC (February 12 – July 16, 2020) demonstrate that the median age of infected healthcare workers was 41…
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