Result for
Topic: Clinical Characteristics and Health Care Setting
September 9, 2020
Acute Kidney Injury and Kidney Replacement Therapy in COVID-19: A Systematic Review and Meta-Analysis
• A meta-analysis of 142 studies (49,048 hospitalized COVID-19 patients) reported a pooled incidence of acute kidney injury (AKI) of 29% (95%CI 20%-40%) in the US and Europe (20 studies) and 6% (95%CI 4%-7%) in China (62 studies). Overall AKI was associated with 4.6-fold increased mortality. Fu et al. (Sept 2, 2020). Acute Kidney Injury…
Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children. JAMA Network Open
• US children with COVID-19 or seasonal influenza had similar rates of hospitalization, intensive care unit admission, and mechanical ventilator use. Song et al. found that among 315 children with laboratory-confirmed COVID-19 and 1,402 children with laboratory-confirmed influenza A or B there was no difference in the level of hospitalization (17% vs 21%), intensive care…
Clinical Outcomes in Young US Adults Hospitalized With COVID-19
Young adults age 18 to 34 years who were hospitalized with COVID-19 in the US (n=3,222) experienced substantial rates of adverse outcomes, including 21% who required intensive care, 10% who required mechanical ventilation, and 3% who died. Morbid obesity, hypertension, and diabetes were common among hospitalized young adults with COVID-19 and were associated with 1.5…
September 8, 2020
Clinical Analysis of Neonates Born to Mothers with or without COVID-19: A Retrospective Analysis of 48 Cases from Two Neonatal Intensive Care Units in Hubei Province
There were no vertical transmissions of SARS-CoV-2 from mother to neonate nor differences in clinical manifestations, radiological and biochemical results among neonates born to 15 women with confirmed and 17 with suspected COVID-19 who delivered in Hubei Province in China. Liu et al. (Sept 6, 2020). Clinical Analysis of Neonates Born to Mothers with or…
September 4, 2020
SARS-CoV-2 Antibodies, Serum Inflammatory Biomarkers and Clinical Severity of Hospitalized COVID-19 Patients
The level of SARS-CoV-2 neutralizing antibodies was highly correlated (r=0.82) with the concentration of IgG antibodies in the sera of 51 hospitalized COVID-19 patients. However, the level of neutralizing antibody responses was not associated with disease severity or inflammatory biomarkers. Gozalbo-Rovira et al. (Sept 1, 2020). SARS-CoV-2 Antibodies, Serum Inflammatory Biomarkers and Clinical Severity of…
Risk Factors for COVID-19 Death in a Population Cohort Study from the Western Cape Province, South Africa
HIV and tuberculosis were each associated with increased risk of COVID-19 mortality in a population cohort study in South Africa (n=3,460,932) that included 625 deaths due to COVID-19. In models adjusted for age, sex, and comorbidities, the HIV-associated risk was 2.1 (95% CI 1.7-2.7), compared to 2.7 (95% CI 1.8-4.0) for current tuberculosis and 1.5…
Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results
Patients classified as having a likely deficient vitamin D level were more likely to test positive for COVID-19 than patients with sufficient vitamin D levels (RR=1.77, 95%CI: 1.12-2.81). [EDITORIAL NOTE: A summary of a pre-print version of this manuscript appeared in the Lit Rep on May 13] Meltzer et al. (Sept 3, 2020). Association of…
Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions
Cytokine levels among patients critically ill with COVID-19 were lower or not significantly different from levels among patients with other critical illnesses, including bacterial septic shock, out-of-hospital cardiac arrest, and multiple traumas. In particular, levels of all 3 cytokines tested (tumor necrosis factor, IL-6, and IL-8) were significantly lower in patients with COVID-19 than in…
September 2, 2020
Cross-Sectional Prevalence of SARS-CoV-2 Among Skilled Nursing Facility Employees and Residents Across Facilities in Seattle
Between March 29 and May 13, 2020, 16 skilled nursing facilities (SNFs) in the Seattle area (1,583 employees and 1,208 residents) were tested for SARS-CoV-2 by PCR, of which 11 (69%) SNFs had one or more employees or residents positive. Overall prevalence of SARS-CoV-2 was 3% among employees and 9% among residents. Despite facility policies…
Does Incubation Period of COVID-19 Vary with Age? A Study of Epidemiologically Linked Cases in Singapore
A study among people with confirmed, locally transmitted SARS-CoV-2 in Singapore (n=164) reported that patients older than 70 years had significantly longer incubation periods for COVID-19 than those younger than 70 years (median 8 days vs. 5 days, p=0.04). Researchers concluded that elderly people may benefit from earlier and proactive testing, especially after exposure to…
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