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Topic: Clinical Characteristics and Health Care Setting
September 2, 2020
Nasopharyngeal Viral Load Predicts Hypoxemia and Disease Outcome in Admitted COVID-19 Patients. Critical Care
Initial SARS-CoV-2 viral load in nasopharyngeal samples was significantly higher among hospitalized patients who required mechanical ventilation and/or subsequently died (n=21) compared to non-mechanically ventilated patients who survived (n=149). Initial SARS-CoV-2 viral load has negatively associated with the lowest level of blood oxygen saturation recorded during hospitalization, but was not associated with other clinical parameters…
September 1, 2020
SARS-CoV-2 Testing and Changes in Primary Care Services in a Multistate Network of Community Health Centers During the COVID-19 Pandemic
Results from an analysis of electronic health record data from a multi-state network of community health centers found that 2% of patients underwent SARS-CoV-2 testing, of whom 28% were positive. There was a higher SARS-CoV-2 testing rate among new patients compared to established patients. Additionally, speaking Spanish, being Hispanic, being uninsured, and speaking a language…
August 31, 2020
Among Frontline Health Care Personnel in a Multistate Hospital Network — 13 Academic Medical Centers
Among 3,248 healthcare workers who regularly had direct patient contact in hospital-based units caring for adults with COVID-19, 194 (6%) had antibody evidence of previous SARS-CoV-2 infection. Of these, 29% were asymptomatic in the preceding months, and 69% had not previously received a diagnosis of SARS-CoV-2 infection. Prevalence of SARS-CoV-2 antibodies was lower among personnel…
Low Risk of COVID-19 among Patients Exposed to Infected Healthcare Workers
Baker et al. found a low risk to patients of acquiring SARS-CoV-2 infection from an infected health care worker. They tested 226 of 238 patients exposed to SARS-CoV-2 by 60 infected health care workers at a large hospital in Boston between March 1 and June 10, 2020 and found that only 2 patients tested positive…
Acceptability of a COVID-19 Vaccine among Adults in the United States: How Many People Would Get Vaccinated?
Sixty-nine percent of respondents to an online survey targeting American adults (n=2,006) were willing to get a COVID-19 vaccine. Participants were more likely to get vaccinated if they thought their healthcare provider would recommend vaccination (RR=1.73) or if they described their political affiliation as moderate (RR=1.09) or liberal (RR=1.14) compared to people who identified as…
August 28, 2020
Prevalence of Surface Contamination With SARS-CoV-2 in a Radiation Oncology Clinic
In a quality improvement study of a radiation oncology department in New Jersey, 128 environmental swabs were obtained following WHO protocols over 6 days from May 1 to May 13 (peak daily rate for New Jersey), of which none were positive for SARS-CoV-2. The investigators suggest routine cleaning and disinfecting protocols appear to be adequate…
Return Hospital Admissions Among 1419 Covid‐19 Patients Discharged from Five US Emergency Departments
A retrospective cohort study of 1,419 patients with COVID-19 who were seen in emergency departments and discharged found that 66 (5%) returned to a hospital within 72 hours and were admitted. Those age > 60 years were more likely to experience a return hospital admission compared to those age 18-39 (aOR=4.6). Hypoxia (aOR=2.9), presentation with…
Clinical Characteristics and Viral RNA Detection in Children with Coronavirus Disease 2019 in the Republic of Korea
Han et al. report a case series of children (age <19 years; n=91) with SARS-CoV-2 across 20 hospitals and 2 isolation facilities across Korea (mid-February to March) and found that 22% of children were asymptomatic. Only 9% of symptomatic cases were diagnosed at the time of symptom onset, while among those with symptoms, 66% had…
Clinical Characteristics of Children and Young People Admitted to Hospital with Covid-19 in United Kingdom: Prospective Multicentre Observational Cohort Study
A prospective observational cohort study in the UK of children and young adults (n=651, median age=4.6, IQR 0.3-13.7) found that 52/456 (11%) participants met the WHO case definition for multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19 (MIS-C). Children who met criteria for MIS-C were older than children who did not (median…
August 27, 2020
Notes from the Field: Universal Statewide Laboratory Testing for SARS-CoV-2 in Nursing Homes — West Virginia
During March 17–April 16, 2020, 307 COVID-19 cases were reported among residents and staff members in 7 nursing homes in West Virginia, 4 of which had outbreaks involving 20–40 residents. In response, the governor ordered universal testing among all 123 nursing homes in the state (April 21–May 8), which resulted in the identification of 42…
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