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Topic: Clinical Characteristics and Health Care Setting
September 15, 2020
Fasting Blood Glucose Level Is a Predictor of Mortality in Patients with COVID-19 Independent of Diabetes History
Elevated fasting blood glucose (≥ 7.0 mmol/L), an indicator of pre-diabetes, was associated with COVID-19 mortality (HR=2.2), independent of diabetes history, in a Chinese cohort of 941 hospitalized patients. The authors conclude fasting blood glucose could be used to screen high-risk patients. Cai et al. (Sept 10, 2020). Fasting Blood Glucose Level Is a Predictor…
Comorbidities Associated with Mortality in 31,461 Adults with COVID-19 in the United States: A Federated Electronic Medical Record Analysis
Older age, male sex, and being Black or African American were significantly associated with mortality from COVID-19 across different age groups in a retrospective cohort study of patients age 18-90 years in the US (n=31,461). Comorbidities associated with higher odds of death varied across age groups and included heart attack history, congestive heart failure, dementia,…
September 11, 2020
Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection
• Among 26 competitive college athletes who had tested positive for SARS-CoV-2 11-53 days earlier and had not require hospitalization, 4 (15%) had cardiac MRI findings suggestive of myocarditis (heart muscle inflammation) and 8 (31%) athletes exhibited late gadolinium enhancement (LGE) without T2 elevation, suggestive of prior myocardial injury. Cardiac ventricular function was within normal…
Elevated D-Dimers and Lack of Anticoagulation Predict PE in Severe COVID-19 Patients
Pulmonary embolism (PE) was diagnosed in 44/162 (27%) patients hospitalized with COVID-19 in a university hospital in France who had severe respiratory disease or rapid clinical worsening and who received computed tomography pulmonary angiography. Elevated D-dimer level (OR=4.0 per additional quartile) and lack of anticoagulant therapy (OR=4.5) were associated with confirmed PE. D-dimer level >2590…
Massachusetts General Hospital Covid-19 Registry Reveals Two Distinct Populations of Hospitalized Patients by Race and Ethnicity
[Pre-print, not peer reviewed] Among hospitalized patients with COVID-19 (n=866) at Massachusetts General Hospital from March 11 to May 4, Hispanic patients were younger and had fewer comorbidities compared to non-Hispanic white patients. Despite comparable rates of ICU care and death, a greater proportion of Hispanic patients recovered by 14 days after presentation. Bassett et…
September 10, 2020
Clinical Characteristics and Outcomes of Immunosuppressed Patients Hospitalized with COVID-19: Experience from London
• In a cohort study of 981 confirmed COVID-19 patients consecutively hospitalized at a large North West London hospital between March 12 and April 15, taking high dose immunosuppressive medications, such as for autoimmune disease or solid organ transplant, was associated with significantly higher mortality rates, supporting the current UK government’s early isolation (“shielding”) policy…
Characteristics, Comorbidities, and Outcomes in a Multicenter Registry of Patients with HIV and Coronavirus Disease-19
• Dandachi et al. found that the severe clinical outcomes of ICU admission, mechanical ventilation, and death occurred commonly in patients with both HIV and COVID-19 (n=286) enrolled from inpatient and outpatient health facilities in the US and three international sites. The risk for poor outcomes was higher in older patients, those with comorbidities (chronic lung…
Incidence of Nosocomial COVID-19 in Patients Hospitalized at a Large US Academic Medical Center
• Transmission of SARS-CoV-2 within the hospital (nosocomial infection) was rare during the height of the pandemic in a cohort study of patients (n=9149) hospitalized over a 12-week period at a large academic medical center with rigorous infection control measures. Only 2% (12/697) of hospitalized COVID-19 patients first tested positive on hospital day 3 or later….
September 9, 2020
Ratios of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Predict All-Cause Mortality in Inpatients with Coronavirus Disease 2019 (COVID-19): A Retrospective Cohort Study in A Single Medical Center
• A study among 131 patients hospitalized with COVID-19 in Wuhan, China (median age 64, IQR 56-71) found that the neutrophil-to-lymphocyte ratio (NLR) at admission was higher (13.9 vs. 2.0) among non-survivors (n=12) when compared to survivors (n=111). The using a NLR of 3.39 or higher was had a sensitivity of 100% and a specificity…
Assessing COVID-19 Transmission to Healthcare Personnel: The Global ACT-HCP Case-Control Study
• Healthcare personnel who had non-aerosol-generating contact with COVID-19 patients were more likely to be infected with SARS-CoV-2 (aOR 1.4, 95%CI 1.0-1.9). The proper use of appropriate PPE was associated with lower risk of infection. These findings were based on an online survey of 1,130 healthcare personnel (244 cases with laboratory-confirmed COVID-19, 22%) from 67…
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