Result for
Topic: Clinical Characteristics and Health Care Setting
August 27, 2020
Clinical Features of Neonates Born to Mothers with Coronavirus Disease-2019: A Systematic Review of 105 Neonates
A systematic review of 14 studies involving 105 neonates born to mothers with COVID-19 found that most had favorable outcomes. Overall, 25 infants (24%) were delivered preterm, 10 (11%) were small for gestational age (SGA), and 28 (27%) had COVID-19 symptoms. Among 91 neonates who were tested for SARS-CoV-2, 8 (9%) were positive. COVID-19 symptoms…
Ocular Manifestations and Clinical Characteristics of Children With Laboratory-Confirmed COVID-19 in Wuhan, China
Ocular manifestations were observed in 49 of 216 (23%) pediatric patients with laboratory-confirmed COVID-19 in Wuhan, China (median age 7, IQR 3-12), of whom 9 had ocular complaints as the initial manifestations of COVID-19. These included conjunctival discharge (55%), eye rubbing (39%), and conjunctival congestion (10%). Ocular symptoms were more common in children with systemic…
August 26, 2020
An Inflammatory Cytokine Signature Predicts COVID-19 Severity and Survival
Measurement of inflammatory markers among hospitalized COVID-19 patients (n=1,484) found that high serum IL-6, IL-8, and TNF-α levels at the time of hospitalization were strong and independent predictors of patient survival. IL-6 and TNF-α serum levels remained significant predictors of disease severity and death after adjustment for disease severity, common laboratory inflammation markers, hypoxia and…
Sex Differences in Immune Responses That Underlie COVID-19 Disease Outcomes
Takahashi et al. found immune responses to SARS-CoV-2 infection differ by sex, suggesting potential factors that contribute to observed sex-based disparities in COVID-19. Among patients with moderate disease who had not received immunomodulatory medications (n=98), male patients had higher plasma levels of innate immune cytokines (e.g., IL-8 and IL-18), along with more robust induction of…
Post-Discharge Persistent Symptoms and Health-Related Quality of Life after Hospitalization for COVID-19
In a single-center study assessing post-discharge persistent symptoms and health-related quality of life of COVID-19 patients (n=279), most patients still had persistent symptoms 110 days after being discharged, especially fatigue (55%) and shortness of breath (42%). Twenty percent of patients, primarily women, reported significant hair loss. Among the participants who were actively working prior to…
August 25, 2020
Follow-up Study of the Pulmonary Function and Related Physiological Characteristics of COVID-19 Survivors Three Months after Recovery
Zhao et al. evaluated COVID-19 survivors (n=55) three months after hospital discharge, none of whom had required mechanical ventilation, and found pulmonary function abnormalities in 14 (25%) despite a lower prevalence of respiratory symptoms (shortness of breath with exertion 15%, cough, and sputum 2%). Thirty-nine participants (71%) had pulmonary abnormalities visible on high-resolution computed tomography….
Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses
Preliminary findings from a cohort study of 192 children (mean age 10.2 +/- 7 years) hospitalized with COVID-19 in Massachusetts show that among participants with acute SARS-CoV-2 infection (n=49) viral load in respiratory secretions in the first 2 days of symptoms was significantly higher compared to that of hospitalized adults with severe disease and more…
More than Loss of Taste and Smell: Burning Watering Eyes in Coronavirus Disease 19
A prospective, observational study of 108 non-hospitalized patients with COVID-19 found 69% reported at least one ocular symptom, the most common being burning sensations (n=39), excessive tearing (n=37), and redness (n=28). Rokohl et al. (Aug 20, 2020). More than Loss of Taste and Smell: Burning Watering Eyes in Coronavirus Disease 19 (COVID-19). Clinical Microbiology and…
August 24, 2020
How Do Presenting Symptoms and Outcomes Differ by Race/Ethnicity Among Hospitalized Patients with COVID-19 Infection? Experience in Massachusetts
McCarty et al. found no association between race or ethnicity and COVID-19-associated morbidity and mortality after controlling for demographic and clinical characteristics (including age, gender, obesity, cardiopulmonary comorbidities, hypertensions, and diabetes) among a cohort of patients with COVID-19 (n=379) patients admitted to nine Massachusetts hospitals. McCarty et al. (Aug 22, 2020). How Do Presenting Symptoms…
COVID-19-Associated Hyperinflammation and Escalation of Patient Care: A Retrospective Longitudinal Cohort Study
Laboratory values indicating hyperinflammation were associated with poor outcomes among patients admitted to hospitals in the UK with COVID-19 (n=269). Patients with hyperinflammation (n=90) had a younger median age (66 vs 71 years) and lower median Charlson Comorbidity Index score (1 vs 2), but a higher proportion of them died during the 28-day follow-up period…
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