Result for
Topic: Clinical Characteristics and Health Care Setting
July 20, 2020
Subjective Smell and Taste Changes during the COVID-19 Pandemic: Short Term Recovery
Reiter et al. used a longitudinal national survey to assess the duration of acute loss of taste and smell associated with COVID-19 infection. After excluding respondents who reported a negative test, they found that after 1-month, 67% reported a return to “very good” or “good” smell and 73% reported a return to “very good” or “good” taste. …
ABO Polymorphism and SARS-CoV-2 Infection – a Meta-Analysis
[pre-print, not peer-reviewed] In a systematic review and meta-analysis, Golinelli et al. concluded that SARS-CoV-2 positive individuals are more likely to have blood group A (pooled OR=1.21, 95%CI 1.08-1.37) and less likely to have blood group O (pooled OR=0.76, 95% CI 0.66-0.87). The analysis included 7 studies with 7,524 SARS-CoV-2 positive cases and 2,962,160 controls. Golinelli et al. (July 17, 2020). ABO Polymorphism and…
Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections in Washington State: A Case Series
In conducting post-mortem examinations of 14 people who died with COVID-19 in Washington state, Bradley et al. found coronavirus-like particles in the respiratory system, kidney, and gastrointestinal tract. One decedent had findings of lymphocytic myocarditis, with SARS-CoV-2 RNA detected in the myocardial tissue. All patients had clinically-significant comorbidities, with the most common being hypertension, chronic kidney disease, obstructive sleep apnea, and metabolic disease including diabetes and obesity. Bradley…
Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System
Bilaloglu et al. found that 533 of 3334 (16%) consecutive patients hospitalized in New York City with COVID-19 had thrombotic events diagnosed during routine clinical care. Age, sex, Hispanic ethnicity, coronary artery disease, prior myocardial infarction, and higher D-dimer levels at hospital presentation were associated with a thrombotic event, and all-cause mortality was higher in those who experienced them (43% vs. 21%). Bilaloglu et al. (July 20, 2020). Thrombosis in Hospitalized…
July 17, 2020
Clinical Characteristics, Comorbidities and Outcomes among Persons with HIV Hospitalized with Coronavirus Disease 2019 in Atlanta, GA
Collins et al. present a case series of people living with HIV (PLWH) admitted with COVID-19 at three hospitals in Atlanta, GA between March 8 and April 23. They found that 4% of hospitalized COVID-19 cases were PLWH. Of these patients, the median age was 57, 65% were men, and 85% were non-Hispanic Black. Cough, fever, malaise, and breathing difficulty were…
Variation in SARS-CoV-2 Prevalence in US Skilled Nursing Facilities
Among 3,357 skilled nursing facilities (SNFs) from at least 25 US states, including a subset of 64 SNFs that performed universal testing, 23% of SNFs had COVID-19 outbreaks. Larger facility size was associated with a significantly higher probability of an outbreak. There was no association between the likelihood of an outbreak and past infection control citations or a measure of SNF quality. White et…
Temperature in Nursing Home Residents Systematically Tested for SARS-CoV-2
Among 7,325 residents of Community Living Centers operated by the Veterans Administration, which perform daily symptoms screening for COVID-19 and conducted universal RT-PCR testing on April 14, SARS-CoV-2 was detected in 6% of residents. Temperatures were elevated in positive participants relative to negatives from 7 days before testing and remained elevated during the 14 day follow-up, but only 27% of positives met the fever threshold…
SARS-CoV-2 Infection Induces Robust Neutralizing Antibody Responses That Are Stable for at Least Three Months
[pre-print, not peer-reviewed] Among over 50,000 individuals with confirmed or suspected SARS-CoV-2 infection or exposure to someone with COVID-19, nearly 20,000 individuals had detectable antibodies. Of those who were antibody positive, 22% had moderate and 71% had high titers for anti-spike antibodies. Approximately half of the samples with low titers were able to neutralize virus, versus 90% and 100% of the samples with moderate and high titers, respectively. Among 121 donors…
Vascular Risk Factors, Framingham Risk Score, and COVID-19: Community-Based Cohort Study
A community-based prospective cohort study using UK Biobank data found that current smoking, physical inactivity, obesity/overweight, and diabetes were all positively associated with SARS-CoV-2 risk (adjusted for age, sex, alcohol intake, education, and ethnicity, and other CVD risk factors). There was no evidence of association for systolic blood pressure. Total cholesterol and HDL were associated with lower risk. Framingham…
Risk Factors for Intensive Care Unit Admission and In-Hospital Mortality among Hospitalized Adults Identified through the U.S. Coronavirus Disease 2019 (COVID-19)-Associated Hospitalization Surveillance Network (COVID-NET)
Among adults (n=2,491) hospitalized with laboratory-confirmed COVID-19 from March 1 to May 2 identified through COVID-NET (154 hospitals in 74 counties and 13 states), 92% had one or more underlying condition, 32% required ICU admission, 19% required invasive mechanical ventilation, and 17% died. Older age, male sex, obesity, immunosuppression, and diabetes were positively associated with ICU admission….
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