Result for
Topic: Clinical Characteristics and Health Care Setting
July 17, 2020
Neurological and Musculoskeletal Features of COVID-19: A Systematic Review and Meta-Analysis
A systematic literature review and meta-analysis (n=51 studies) of neurological and musculoskeletal features of COVID-19 found the prevalence of smell impairment was 35% (95% CI 0-94%), 33% for taste impairment (95% CI 0-91%), 19% for myalgia (95% CI 16-23%), 12% for headache (95% CI 9-15%), 10% for back pain (95% CI 1%-23%), 10% for dizziness (95% CI 3-19%), 3%…
July 16, 2020
Deep Immune Profiling of COVID-19 Patients Reveals Distinct Immunotypes with Therapeutic Implications
Using deep immune profiling, Mathew et al. characterized immune responses among 125 patients with COVID-19 and identified 3 different immunotypes with unique T cell, B cell, and lymphocyte responses. These findings may suggest fundamental differences in immunological responses to SARS-COV-2 infection. Mathew et al. (July 15, 2020). Deep Immune Profiling of COVID-19 Patients Reveals Distinct Immunotypes with Therapeutic Implications. Science. https://doi.org/10.1126/science.abc8511
BMI and Future Risk for COVID-19 Infection and Death across Sex, Age and Ethnicity: Preliminary Findings from UK Biobank
Sattar et al. analyzed participants (n=4,855) from the UK Biobank and found a strong association between BMI and a positive SARS-CoV-2 test and COVID-19 related death. The gradient of risk across the range of BMI was steeper among those under 70 for COVID-19 related death. BMI was more strongly related to test positivity and death among members of non-white racial groups. …
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
In a US multicenter cohort study of COVID-19 patients admitted to ICU (n=2,215), independent risk factors associated with 28 day mortality included older age (≥80 vs <40 years of age: OR=11.15), male sex (OR=1.50), obesity (BMI ≥40 vs <25: OR=1.51), coronary artery disease (OR=1.47), active cancer (OR=2.15), and acute organ dysfunction (OR=2.43 to 2.61). Patients admitted to a hospital with fewer ICU beds had a higher risk of death (<50 vs ≥100…
Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy
In a retrospective cohort study of critically ill patients admitted to ICUs in Italy (n=3,988), independent risk factors associated with mortality included older age (HR=1.75), male sex (HR=1.57), history of COPD (HR = 1.68), history of diabetes (HR=1.18), hypercholesterolemia (HR=1.25), and poor respiratory status at ICU admission, as defined by three measures. The hospital mortality rate as of May 30 was 12 per 1000 patient…
July 15, 2020
Association Between Universal Masking in a Health Care System and SARS-CoV-2 Positivity Among Health Care Workers
Among 9,850 health care workers Massachusetts between March 1 and April 30, 2020 13% were positive for SARS-CoV-2 by RT-PCR. Prior to implementation of universal masking (March 1-24, 2020), the SARS-CoV-2 positivity rate increased exponentially from 0% to 21%, with a case doubling time of 3.6 days (95%CI 3.0-4.5 days). After implementation of universal masking (April 11-30, 2020), the positivity rate decreased linearly from 14.7% to 11.5%, with a weighted mean…
Comparison of Mortality Risk in Patients with Cirrhosis and COVID-19 Compared with Patients with Cirrhosis Alone and COVID-19 Alone: Multicentre Matched Cohort
A multicenter study in the US compared 37 inpatients with cirrhosis and COVID-19 to age– and gender-matched patients with COVID-19 alone (n=108) or cirrhosis alone (n=127). Results showed that patients with cirrhosis and COVID-19 had a non-significantly higher mortality compared to patients with cirrhosis alone (30% vs 20%, p=0.16), and significantly higher mortality than patients with COVID-19 alone (30% vs 13%, p=0.03). The elevated mortality among those with cirrhosis and COVID-19 may…
July 14, 2020
Liver Injury in Critically Ill and Non-Critically Ill COVID-19 Patients: A Multicenter, Retrospective, Observational Study
Results from a retrospective observational study (n=131) across three hospitals in Zhejiang, China suggest that critically ill COVID-19 patients suffered earlier occurrence, greater injury severity, and slower recovery from liver injury compared to non-critically ill patients. The combination treatment of lopinavir/ritonavir and arbidol was associated with higher risk or liver injury among non-critically ill patients (OR=3.58, 95%CI: 1.44-9.52). Jiang…
Incidence of Acute Kidney Injury and Its Association with Mortality in Patients with COVID-19: A Meta-Analysis.
A meta-analysis of 26 studies (n=5,497) showed that acute kidney injury is present in 8% of COVID-19 patients overall and 20% of critically ill patients with COVID-19. Renal replacement therapy was estimated to occur in 4% of cases in the study populations. Acute kidney injury is associated with a 13-fold increased risk of mortality. Hansrivijit et al. (July 12, 2020). Incidence of Acute Kidney Injury and Its Association with Mortality in…
Disproportionate Impact of the COVID-19 Pandemic on Immigrant Communities in the United States
Anticipating disparate COVID-19 outcomes among immigrant communities, particularly in Texas, Clark et al. advocate policy recommendations such as Medicaid expansion, funding for testing and treatment for uninsured individuals regardless of immigration status, and prohibiting ICE operations near health facilities. Clark et al. (July 13, 2020). Disproportionate Impact of the COVID-19 Pandemic on Immigrant Communities in the United States. PLOS Neglected Tropical…
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