Result for
Topic: Clinical Characteristics and Health Care Setting
July 9, 2020
Systematic Review with Meta-Analysis: Liver Manifestations and Outcomes in COVID-19
A systematic review and meta-analysis (107 studies, 20,874 COVID-19 patients) shows that the severity of elevated liver chemistries is associated with the outcome of COVID-19; however, the presence of chronic liver disease does not alter the outcome of COVID-19. COVID-19 patients with elevated liver chemistries had increased risk of mortality (OR=3.46; 95%CI 2.42-4.95) and severe disease (OR=2.87; 95%CI 2.29-3.6)…
Persistent Symptoms in Patients After Acute COVID-19
A study of 147 patients in Italy who had recovered from COVID-19 found that 87% reported persistence of at least 1 symptom, particularly fatigue and dyspnea (difficulty breathing) at a mean of 60 days (SD 13.6) after onset of symptoms. Carfì et al. (July 9, 2020). Persistent Symptoms in Patients After Acute COVID-19. JAMA. https://doi.org/10.1001/jama.2020.12603
Coronavirus Disease 2019 Pandemic Measures: Reports From a National Survey of 9,120 ICU Clinicians
Based on a survey of 9,120 ICU clinicians across the US, Kleinpell et al. identified personal protective equipment, specifically N95 respirator availability, and ICU staffing as the most critical ICU needs. 31% of ICU clinicians reported that minimizing healthcare worker virus exposure during care was the most challenging aspect of COVID-19 patient care. Both nurses and ICU clinicians who had provided care to COVID-19 patients reported a high level of concern about exposing family members to SARS-CoV-2 (median score of…
OpenSAFELY: Factors Associated with COVID-19 Death in 17 Million Patients
Williamson et al. linked primary care records of 17,278,392 adults in England (40% of all patients nationally) to 10,926 COVID-19-related deaths and found that COVID-19-related death was associated with being male (HR=1.59; 95% CI 1.53-1.65), older age and lower socioeconomic status (both with a strong gradient), diabetes, severe asthma, and various other medical conditions. Compared to…
July 8, 2020
Investigating SARS-CoV-2 Surface and Air Contamination in an Acute Healthcare Setting during the Peak of the COVID-19 Pandemic in London
Zhou et al. collected air and surface samples from seven clinical areas occupied by COVID-19 patients, as well as one public area of a London hospital. Overall, viral RNA was detected on 52% (114/218) of surfaces and 39% (14/31) of air samples, but no virus was cultured. Viral RNA was more likely to be found…
Race, Socioeconomic Deprivation, and Hospitalization for COVID-19 in English Participants of a National Biobank
In a UK cohort of biobank participants, 549 were hospitalized for COVID-19. Black (OR 3.7; 95% CI: 2.5-5.3) and Asian (OR 2.2; 95% CI: 1.5-3.2) participants had a significantly higher risk of COVID-19 hospitalization relative to white participants. These disparities persisted, even after adjusting for socioeconomic deprivation, household income, and cardiorespiratory comorbidities. Patel et al. (July 6,…
Pregnancy and Postpartum Outcomes in a Universally Tested Population for SARS-CoV-2 in New York City: A Prospective Cohort Study
All pregnant patients who were admitted for delivery at three New York City hospitals were screened for SARS-CoV-2 using RT-PCR testing of nasopharyngeal specimens (first 28 days of universal screening that started on March 22, 2020). Of 675 people admitted for delivery, 10% were positive for SARS-CoV-2, among whom most (79%) were asymptomatic. Cesarean delivery and post-partum complications…
July 7, 2020
Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients
Borsetto et al. conducted a systematic review and meta-analysis (18 studies with 3,563 patients) that assessed the prevalence of self-reported altered sense of smell or taste in patients with confirmed COVID-19. They found alterations in smell or taste among 31% of participants with severe COVID-19 and 67% of participants with mild-to-moderate COVID-19, with an overall prevalence of 47%. In 20% of participants, the alteration preceded other symptoms, suggesting…
Association of initial viral load in SARS-COV-2 patients with outcome and symptoms
Argyropoulos et al. found that higher SARS-CoV-2 viral load was associated with shorter duration of symptoms prior to testing among patients seen in emergency departments in New York City (n=205) and was associated with shorter duration of stay for hospitalized patients (n=40).Viral load was not associated with admission to ICU, length of oxygen support, or overall survival. The authors suggest that higher viral loads are seen in mild rather…
Seroprevalence of SARS-CoV-2 Among Frontline Healthcare Personnel During the First Month of Caring for COVID-19 Patients — Nashville, Tennessee
Stubblefiled et al. conducted a cross-sectional seroprevalence study for SARS-CoV-2 antibodies among healthcare workers in Nashville, TN 4 weeks after the first identified case in the study hospital. Among 249 healthcare personnel who worked in units with COVID-19 patients, 19 (8%) tested positive for SARS-CoV-2 antibodies. Only 11 (58%) of the 19 personnel with positive serology reported symptoms…
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