Result for
Topic: Clinical Characteristics and Health Care Setting
July 14, 2020
SARS‐CoV‐2 and HIV Coinfection: Clinical Experience from Rhode Island, United States
A case series of individuals co–infected with HIV and SARS-CoV-2 (n=27) from a Rhode Island hospital suggests that clinical presentations and outcomes are similar to persons without HIV. Byrd et al. (July 13, 2020). SARS‐CoV‐2 and HIV Coinfection: Clinical Experience from Rhode Island, United States. Journal of the International AIDS Society. https://doi.org/10.1002/jia2.25573
July 13, 2020
COVID-19: Outcomes of Patients with Confirmed COVID-19 Re-Admitted to Hospital
Among 391 COVID-19 patients discharged from the North Middlesex University Hospital in London, 39 re-presented to the hospital emergency department, including 25 that were re-admitted, 2 that required ICU care, 3 that died, and 3 who were discharged home as part of end-of-life care. Average time to re-admission was 10 days, and median age of the re-admission group was higher than the discharged patients (73 vs 59 years). The authors…
Rate of Intensive Care Unit Admission and Outcomes among Patients with Coronavirus: A Systematic Review and Meta-Analysis
A systematic review (n=37 articles, 24,983 participants) of coronavirus (SARS-CoV, SARS-CoV-2, MERS-CoV) outcomes found the rate of ICU admission was 32% (95%CI 26%, 38%), and pooled case fatality among ICU patients was 39% (95%CI 34%, 43%). Among US studies (n=5), case fatality among ICU patients was 36% (95%CI 18%, 53%). Abate et al. (2020). Rate of Intensive Care Unit Admission and Outcomes among…
Decontamination and Reuse of N95 Filtering Facemask Respirators: A Systematic Review of the Literature
A systematic review (n=14 studies) found that ultraviolet germicidal irradiation and vaporized hydrogen peroxide were the most promising decontamination methods for N95 filtered face masks, based on ability to reduce pathogen load while maintaining filtration function and without residual toxicity. Rodriguez-Martinez et al. (July 2020). Decontamination and Reuse of N95 Filtering Facemask Respirators: A Systematic…
A Case-Control and Cohort Study to Determine the Relationship between Ethnic Background and Severe COVID-19
[pre-print, not peer-reviewed] Based in a case-control study (872 hospitalized COVID-19 patients and 3,488 controls) and a cohort study (1,827 adults admitted with COVID-19) conducted among inner–city adult residents in London, Black and Mixed/Other ethnicity were associated with a significantly higher admission risk than white ethnicity (OR=3.1, 95% CI 2.6-3.7 and OR=3.0, 95% CI 2.3-3.9, respectively). Among patients hospitalized for COVID-19, 29% died over a median of…
Intensive Care Admissions of Children with Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) in the UK: A Multicentre Observational Study
Davies et al. conducted a multi-center study of children admitted to PICUs in the UK who met the case definition of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) (n=78). Historical data on admissions for similar conditions found a mean of 1 admission per week, as compared to a mean of 14 cases per week during…
July 10, 2020
Does a Modified Adhesive Respirator Improve the Face Seal for Health Care Workers Who Previously Failed a Fit Test?: A Pilot Study During the Coronavirus Disease 2019 Pandemic
Use of double-sided adhesive tape on the inside edges of the 3M respirators resulted in successful fit tests for 17 (68%) out of 26 healthcare workers who had previously failed the respirator fit test. Wardhan et al. (June 15, 2020). Does a Modified Adhesive Respirator Improve the Face Seal for Health Care Workers Who Previously Failed a Fit Test?: A Pilot Study…
Disinfection of N95 Masks Artificially Contaminated with SARS-CoV-2 and ESKAPE Bacteria Using Hydrogen Peroxide Plasma: Impact on the Reutilization of Disposable Devices
A hydrogen peroxide plasma disinfection protocol inhibited the detection of SARS-CoV-2 by RT-PCR on N95 masks that had been inoculated with various dilutions of SARS-CoV-2 in viral media. Ibáñez-Cervantes et al. (July 10, 2020). Disinfection of N95 Masks Artificially Contaminated with SARS-CoV-2 and ESKAPE Bacteria Using Hydrogen Peroxide Plasma: Impact on the Reutilization of Disposable Devices. American Journal of Infection Control. https://doi.org/10.1016/j.ajic.2020.06.216
Change in the Incidence of Stillbirth and Preterm Delivery During the COVID-19 Pandemic
Khalil et al. found that the incidence of stillbirth was significantly higher during the COVID-19 pandemic than prior (9.31 per 1000 births vs 2.38 per 1000 births, p=0.01) at St. George’s University Hospital, London even though none of the mothers were known be infected with SARS-CoV-2. The authors hypothesize that the increase in stillbirth could be directly due to SARS-CoV-2 in asymptomatic…
July 9, 2020
Clinical Characteristics of Patients With Coronavirus Disease 2019 (COVID-19) Receiving Emergency Medical Services in King County, Washington
Based on a study of patients who required 911 emergency medical services (EMS) care for COVID-19 in King County, Washington (February 1 to March 18), screening based on conventional COVID-19 symptoms or examination findings of febrile respiratory illness may not be sufficiently sensitive to identify patients with COVID-19. Of 147 unique 911 encounters, 29% had no symptoms of fever, cough, or shortness of breath. Based on EMS examination findings, fever (51%), tachypnea (rapid breathing) (32%), or hypoxia (54%) were only present in a…
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