Result for
Topic: Clinical Characteristics and Health Care Setting
May 27, 2020
Cancer and Risk of COVID-19 through a General Community Survey
[pre-print, not peer reviewed] Lee et al. evaluated the effect of cancer-related treatments on the risk for COVID-19 among >1.8 million patients living with cancer in the UK, US and Sweden. They found that individuals with cancer had a significantly increased risk (aOR 1.62, 95%CI 1.37-1.91) of COVID-19 compared to the general community. Those treated with chemotherapy or immunotherapy were particularly at risk (aOR: 2.42; 95%CI: 1.81-3.25). …
May 26, 2020
Risk Stratification of Hospitalized COVID-19 Patients through Comparative Studies of Laboratory Results with Influenza
[pre-print, not peer reviewed] Comparing clinical and laboratory results from 719 influenza and 973 COVID-19 patients from January to April, using parameters that are most significantly different between COVID-19 and influenza, COVID-19 patients were sub-classified into 5 clusters through a hierarchical clustering analysis. Risk stratification of these clusters using medical record review found that the highest-risk cluster had…
Coronavirus Disease 2019 Test Results After Clinical Recovery and Hospital Discharge Among Patients in China
PCR tests on nasopharyngeal and anal swabs from 60 patients who had been hospitalized for COVID-19 found evidence of persistent viral shedding following discharge. Samples were collected 4-24 days after index hospital discharge and 10 out of 60 patients had positive results (16.7%; 5 nasopharyngeal and 6 anal). None of these patients had clinical symptoms of COVID-19 at the time of sample collection except for occasional…
Analysis of Maternal Coronavirus Infections and Neonates Born to Mothers with 2019-NCoV; a Systematic Review
A systematic literature review that included 9 studies corresponding to 89 pregnant women with SARS-CoV-2 infection and their neonates found low-grade fever and cough were the predominant symptoms, and that fetal distress, premature rupture of membranes, and preterm labor were the most common prenatal complications. Two women required ICU admission and ventilation, and one developed multi-organ dysfunction. No maternal deaths…
Clinical Features and Outcomes of 105 Hospitalized Patients with COVID-19 in Seattle, Washington
A descriptive study of all laboratory-confirmed COVID-19 adult patients admitted to an academic medical center in Seattle, WA between March 2 and March 26, 2020 (n=105) found that 35% were admitted from a senior home or skilled nursing facility. Median age was 69 years and half were women. Three or more comorbidities were present in 55% of…
Incidence, Clinical Outcomes, and Transmission Dynamics of Severe Coronavirus Disease 2019 in California and Washington: Prospective Cohort Study.
Out of over 9 million healthcare plan enrollees in northern California, southern California, and Washington State, the cumulative incidence of first hospital admission for COVID-19 by April 22 was 15.6 per 100,000 persons in northern California, 23.3 per 100,000 persons in southern California, and 14.7 per 100,000 persons in Washington. Median duration of hospital stay was…
May 22, 2020
Clinical Predictors of COVID-19 Mortality
[pre-print, not peer reviewed] Machine learning techniques were applied to clinical data from a cohort of 5,051 COVID-19 patients in New York City to predict mortality (training set of n=3,841). A mortality predictor based on five clinical features (age, minimum oxygen saturation, type of encounter, hydroxychloroquine use, and maximum body temperature) had good predictive performance (AUC=0.91) on a test set of retrospective (n=961) and prospective…
Characterization of Patients Who Return to Hospital Following Discharge from Hospitalization For COVID-19
[pre-print, not peer reviewed] A retrospective cohort of 2,864 COVID-19 patients discharged from five New York City hospitals found 103 (3.6%) returned for emergency care after a median of 4.5 days, with 56 requiring re–admission. In 50% of cases the reason for return was respiratory distress. Patients who returned had a higher burden of COPD and hypertension, had a shorter…
Development and Implementation of a Clinician-Facing Prognostic Communication Tool for Patients with COVID-19 and Critical Illness
Survival data and descriptions of best- and worst-case clinical scenarios were used to create an online COVID-19 Prognostication Tool. The visual infographic tool includes prompts for clinician reflection to enhance awareness of cognitive biases that may affect their prognostic accuracy. Gibbon et al. (May 2020). Development and Implementation of a Clinician-Facing Prognostic Communication Tool for Patients with COVID-19 and Critical Illness. Journal of…
May 21, 2020
Work-Related COVID-19 Transmission in Six Asian Countries/Areas: A Follow-up Study
Lan et al. found work-related transmission likely played a large role in early SARS-CoV-2 outbreaks (48% of 690 cases within the first 40 days of outbreaks in 6 Asian settings). Occupation groups with the most confirmed cases were healthcare workers (22%), drivers/transport workers (18%), services and sales workers (18%), cleaning and domestic workers (9%) and public safety workers (7%). Lan…
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