Result for
Topic: Clinical Characteristics and Health Care Setting
May 21, 2020
Symptomatic Infants Have Higher Nasopharyngeal SARS-CoV-2 Viral Loads but Less Severe Disease than Older Children
Among 57 SARS-CoV-2 positive patients admitted to a children’s hospital in China, 20 (35%) were infants and 37 (65%) were children and adolescents. Although the mean nasopharyngeal viral load was higher in infants (21.1 vs. 27.3 Ct, p-value < 0.001), a lower proportion of infants had severe disease: 1 (5%) infant compared to 12 (32%) of…
May 20, 2020
Epidemiology, Clinical Course, and Outcomes of Critically Ill Adults with COVID-19 in New York City: A Prospective Cohort Study
An observational cohort study identified 1,150 adults with laboratory confirmed COVID-19 admitted to two New York hospitals and followed 257 (22%) critically ill participants for the primary outcome of in-hospital mortality. Results support previous studies showing that older age and cardiopulmonary comorbidities were associated with increased in-hospital mortality while also adding biomarkers for inflammation and thrombosis as independent risk factors. Cummings et…
May 19, 2020
Acute Heart Failure in Multisystem Inflammatory Syndrome in Children (MIS-C) in the Context of Global SARS-CoV-2 Pandemic
A retrospective analysis of children in France and Switzerland suggests that children may experience acute heart failure and multisystem inflammatory syndrome following SARS-CoV-2 infection. Among 35 children admitted to pediatric intensive care for cardiogenic shock, left ventricular dysfunction, or a severe inflammatory state, 88% (31/35) of patients tested positive for SARS-CoV-2 infection. Belhadjer et al….
Distinct Systems Serology Features in Children Elderly and COVID Patients
Selva et al. investigated the cross-reactivity of SARS-CoV-2 and other circulating human coronavirus antibody responses in healthy children (n=89), adults (n=98), elderly (n=57), and COVID-19 patients (n=19). Their results suggest that less-experienced humoral immunity that is observed in children, associated with higher IgM, may have the potential to induce more potent antibodies upon SARS-CoV-2 infection,…
May 18, 2020
Use of Renin-Angiotensin-Aldosterone System Inhibitors and Risk of COVID-19 Requiring Admission to Hospital: A Case-Population Study
Despite earlier concerns, de Abajo et al. found no evidence that RAAS inhibitors increase the risk of COVID-19 requiring admission to hospital, including fatal cases and those admitted to ICUs. The authors conducted a case-population study in Madrid, Spain including 1,139 patients and controls matched for age, sex, region, and date of admission to hospital at a ratio of 10:1….
Children with Coronavirus Disease 2019 (COVID-19): A Review of Demographic, Clinical, Laboratory and Imaging Features in 2,597 Pediatric Patients
Among a cohort of 2,597 pediatric patients with COVID-19, a low proportion exhibited lymphopenia (9.8%) compared to adults. Elevated creatine kinase MB isoenzyme was much more commonly observed in children (27%) than that in adults, raising some concerns about heart injury in pediatric patients. Cui et al. (May 17, 2020). Children with Coronavirus Disease 2019 (COVID-19): A Review of Demographic, Clinical, Laboratory…
May 15, 2020
Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City
Though previous studies have shown that children are at lower risk of developing severe illness compared to adults, the incidence of critical illness among children with COVID-19 is still not well known. Chao et al. observed 46 COVID-19 positive children (median age = 13.1) hospitalized in New York, and report that 28% were admitted to the pediatric intensive…
Hypoalbuminemia Predicts the Outcome of COVID‐19 Independent of Age and Co‐morbidity
This retrospective cohort study found a considerable difference in albumin levels between survivors and non-survivors of COVID-19. Results also showed that hypoalbuminemia was a predictive factor for mortality (OR = 6.4, 95%CI: 1.3, 31.1). Huang et al. (May 14, 2020). Hypoalbuminemia Predicts the Outcome of COVID‐19 Independent of Age and Co‐morbidity. Journal of Medical Virology. https://doi.org/10.1002/jmv.26003
Combination of Four Clinical Indicators Predicts the Severe/Critical Symptom of Patients Infected COVID-19
Using data on all 336 cases of COVID-19 in Shanghai, China through March 12, as well as 220 clinical and laboratory records, Sun et al. built a risk prediction model for discriminating severe/critical illness. Thirty-six clinical indicators were found to be significantly associated with severe/critical symptoms. The AUC for the final model (Support Vector Machine) for discriminating severe/critical cases from…
May 14, 2020
A Novel Box for Aerosol and Droplet Guarding and Evacuation in Respiratory Infection (BADGER) A Potential Mitigating Strategy for the COVID-19 Pandemic and Future Outbreaks
Oberstar et al. report on the development of an affordable and scalable device that can contain droplets and aerosol particles for potentially use by healthcare providers treating COVID-19 patients. The BADGER (Box for Aerosol and Droplet Guarding and Evacuation in Respiratory Infection) creates a semi-sealed environment and has multiple hand-ports for healthcare providers to perform essential tasks…
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