Result for
Topic: Clinical Characteristics and Health Care Setting
June 2, 2020
Profiling Serum Cytokines in COVID-19 Patients Reveals IL-6 and IL-10 Are Disease Severity Predictors
Han et al. found that levels of cytokines and C-reactive protein were higher in serum samples from COVID-19 patients (n=102) than control samples from healthy volunteers (n=45). Within COVID-19 patients, IL-6 and IL-10 levels were significantly higher in the critical group, indicating that higher levels of cytokine storm are associated with more severe disease development. Han et al. (May 31, 2020). Profiling Serum Cytokines in…
SARS-CoV-2 Infects and Induces Cytotoxic Effects in Human Cardiomyocytes
[pre-print, not peer reviewed] By inducing infection in cardiac tissue models and living human heart slices, Bojkova et al. demonstrate that cardiomyocytes (heart cells) can be directly infected with SARS-CoV-2. This study may provide evidence to explain the association between elevated markers of cardiac injury with higher risk of mortality in COVID-19 patients. Bojkova et al. (June 1, 2020). SARS-CoV-2 Infects…
June 1, 2020
COVID-19 Mortality in Patients with Cancer on Chemotherapy or Other Anticancer Treatments: A Prospective Cohort Study
Lee et al. report that a multicenter observational study in the UK found no evidence that cancer patients receiving cytotoxic chemotherapy or other anticancer treatment were at an increased risk of mortality from COVID-19 compared to those not on active treatment. The mortality is principally driven by advancing age and non-cancer comorbidities. Withholding effective cancer treatments during the pandemic may result in increased cancer morbidity and mortality without preventing deaths from COVID-19. Lee et…
May 29, 2020
Excess Out-of-Hospital Deaths during COVID-19 Outbreak: Evidence of Pulmonary Embolism as a Main Determinant
Investigators in Paris, France found that pulmonary embolism identified by post-mortem CT was much higher among those who had unexplained deaths during the COVID-19 outbreak compared to a control group who had unexplained deaths in 2019. Furthermore, the prevalence of unexplained deaths was much higher during the COVID-19 outbreak compared to 2019. These results suggest the need for additional PPE when handling bodies of…
New York City COVID-19 Resident Physician Exposure during Exponential Phase of Pandemic
Among 91 medical residency programs, representing 2,306 residents around New York City, 45.1% of programs report at least one resident with confirmed COVID-19. These include 101 residents with confirmed positive tests (2 of whom were hospitalized), and 163 residents who were presumed positive but not tested. Anesthesiology, emergency medicine, and ophthalmology appeared to cluster as high-risk specialties based on the proportion of residents with confirmed COVID-19. Mask reuse or extended mask use was reported by 90 out of 91 programs,…
Description of COVID-19 in HIV-Infected Individuals: A Single-Centre, Prospective Cohort
Vizcarra et al. compared the characteristics of 51 HIV–infected individuals diagnosed with COVID-19 in Spain to 1,288 HIV-infected individuals not diagnosed with COVID-19 and found that age and CD4 cell count were similar between the groups, but that a greater proportion of persons with COVID-19 had at least one comorbidity (63% vs. 38%). The clinical and radiological presentation…
May 28, 2020
Seroprevalence of SARS-CoV-2 among Children Visiting a Hospital during the Initial Seattle Outbreak
[pre-print, not peer reviewed] Dingens et al. serologically screened residual samples from 1,076 pediatric patients at Seattle Children’s Hospital for evidence of past SARS-CoV-2 infection. Only 10 (1%) children were seropositive; however, most seropositive children (8/10) were not suspected of having had COVID-19. Dingens et al. (May 28, 2020). Seroprevalence of SARS-CoV-2 among Children Visiting a Hospital during the Initial Seattle Outbreak. Pre-print downloaded May 28 from https://doi.org/10.1101/2020.05.26.20114124
Comparison of Clinical Characteristics of Patients with Asymptomatic vs Symptomatic Coronavirus Disease 2019 in Wuhan, China
Among 78 SARS-CoV-2 positive patients who were exposed to the Hunan seafood market or had close contact with other patients with COVID-19 in Wuhan, China, 42% were asymptomatic and 58% were symptomatic. Those who were asymptomatic were younger and more likely to be women (67% v 31%), compared to symptomatic patients. Asymptomatic patients also had a shorter duration of viral shedding from nasopharynx…
Hospitalization and Mortality among Black Patients and White Patients with Covid-19
Black patients disproportionately accounted for COVID-19 hospitalizations and deaths in a Louisiana integrated-delivery health system: 77% of hospitalizations and 71% of deaths were patients who were black, despite black residents comprising only 31% of the total population. Black race was associated with increased odds of hospitalization, even after controlling for age, comorbidities, use of public insurance (e.g. Medicare or Medicaid), residence in a…
COVID-19 Infections among Healthcare Workers Exposed to a Patient with a Delayed Diagnosis of COVID-19
Baker et al. report on a case in which 44 healthcare workers (HCW) were exposed to a single undiagnosed COVID-19 patient over a 13-day period. During this period, the patient stayed in a single room and HCWs did not use contact and droplet precautions. On the 13th day of hospitalization, the patient developed sudden acute…
Previous page Next page