Result for
Topic: Clinical Characteristics and Health Care Setting
April 29, 2020
The values of coagulation function in COVID-19 patients
Jin et al retrospectively investigate blood coagulation function in 147 COVID-19 patients, and the correlation between coagulopathy and disease severity in Wuhan Hospital. Patients with thrombotic disease had a higher case-fatality and were also associated with disease severity. T-PA/PAI-1 Complex and D-Dimer were independent risk factors and predictors for death in patients. The coagulation systems…
Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence
This review paper addresses the challenges of cancer management in the era of SARS-CoV-2. It discusses the epidemiological, clinical, pathological and radiological characteristics of the disease in cancer patients and its outcomes on this population. The authors focus on strategies that are followed in cancer management with review of national and international guidelines. Moujaess et…
April 28, 2020
Persistent viral RNA positivity during recovery period of a patient with SARS-CoV-2 infection
This case report describes a SARS-CoV-2 infection with a clinical course of over 2 months, including reappearing viral RNA in saliva concurrent with viral specific antibodies. Findings indicate that SARS-CoV-2 can cause a long clinical course, and imply an immune evasion from the host immune system. Yang et al. (April 24, 2020). Persistent viral RNA…
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
The authors discuss findings from five cases of large-vessel stroke in SARS-CoV-2 patients under 50 years of age in New York City. Oxley et al. (April 27, 2020). Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. NEJM. https://doi.org/10.1056/NEJMc2009787
Vitamin D insufficiency is prevalent in severe COVID-19
This 20-patient retrospective observational study suggests a link between Vitamin D insufficiency (VDI) and severe COVID-19. Anecdotal and observational data indicate that VDI may play a significant role in the disease progression of COVID-19. Lau et al. (April 28, 2020). Vitamin D insufficiency is prevalent in severe COVID-19. Pre-print downloaded Apr 28 from https://doi.org/10.1101/2020.04.24.20075838
April 27, 2020
Transmission risk of SARS-CoV-2 to healthcare workers – observational results of a primary care hospital contact tracing
Vera et al tracked 21 healthcare worker contacts of an initially undiagnosed COVID-19 case who were without PPE, including facemasks. All healthcare workers tested negative 7 days after initial index case contact. The team found a low risk of SARS-CoV-2 transmission in a primary care setting, and concluded that the current protective measures for healthcare…
Neonatal Resuscitation Where the Mother Has a Suspected or Confirmed Novel Coronavirus (SARS-CoV-2) Infection: Suggestion for a Pragmatic Action
This perspective aims to provide a practical support tool for the planning of delivery and neonatal resuscitation of infants born by mothers with suspected or confirmed COVID-19 infection. Trevisanuto et al. Neonatal Resuscitation Where the Mother Has a Suspected or Confirmed Novel Coronavirus (SARS-CoV-2) Infection: Suggestion for a Pragmatic Action. Neonatology: preprint downloaded April 24…
April 24, 2020
Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers at the onset of the U.S. COVID-19 epidemic
Barrett et al report on the prevalence of SARS-CoV-2 infection in previously undiagnosed U.S. healthcare workers in the early phase of the U.S. COVID-19 epidemic. They report a prevalence of 7.3 and 0.4% SARS-CoV-2 infection in healthcare and non-healthcare workers, respectively. They attribute the 7.0% greater absolute risk to high levels of close patient contact…
Rapid identification of SARS-CoV-2-infected patients at the emergency department using routine testing
This easy-to-use point-based algorithm, called the corona-score, uses laboratory parameters, demographic data and the chest X-ray/CT of patients to rapidly evaluate an individual’s risk of SARS-CoV-2 infection at the emergency department (ED). The algorithm has a sensitivity of 95% and specificity of 96%, and could have important utility in EDs experiencing a shortage of RT-PCR…
April 23, 2020
Clinical Characteristics of Hospitalized Covid-19 Patients in New York City
Paranjpe et al conducted a descriptive study of about 2,200 patients from the 5 Mount Sinai Health System hospitals in New York. Key findings from this study include: i) of 49% of patients completing their hospital course, the overall mortality was 29% and 36% required intensive care; ii) median age was 65 years overall and…
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