Result for
Topic: Clinical Characteristics and Health Care Setting
May 1, 2020
Cardiovascular Manifestations and Treatment Considerations in Covid-19
Cardiovascular disease (CVD) is a risk factor for severe COVID-19 disease and mortality. Additionally, evidence of myocardial injury (defined as elevation of high-sensitivity cardiac troponin (hs-cTn)) is common in COVID-19 patients and portends a worse prognosis. Increased levels of hs-cTn correlate with disease severity and mortality in COVID-19 patients, even after controlling for comorbidities. The…
High Frequency of SARS-CoV-2 RNAemia and Association with Severe Disease
Detection of SARS-CoV-2 RNA in the blood is associated with poor clinical outcomes and increased mortality among COVID-19 patients. In this study, SARS-CoV-2 RNA was detected in 33% (28/85) of patients, the majority of whom were hospitalized (22/28). Detection of RNA occurred more frequently in individuals who required an ICU transfer (32% v 14%; p=0.05),…
Second-Trimester Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection
Baud et al. present a single case report of a second trimester miscarriage in a pregnant woman with COVID-19. The authors found evidence that the miscarriage was related to placental infection with SARS-CoV-2. Findings from a placental histological examination and fetal autopsy found that the placental submembrane and cotyledon both tested positive for SARS-CoV-2, while…
Co-infection in SARS-CoV-2 infected Patients: Where Are Influenza Virus and Rhinovirus/Enterovirus?
Recent case reports suggest that people co-infected with SARS-CoV-2 and other respiratory viruses (such as influenza virus and seasonal coronaviruses) may have higher morbidity and mortality. However, Nowak et al. found that co-infection was uncommon. In a retrospective review of laboratory results from 8 inpatient and associated outpatient facilities in the greater New York City…
Obesity could shift severe COVID-19 disease to younger ages
Kass et al. suggest that in populations with high prevalence of obesity, COVID-19 will affect younger populations more than previously reported. Among 265 patients admitted to ICU at 6 university hospitals across the U.S., there was a significant inverse correlation between age and BMI, such that younger individuals admitted to hospital were more likely to…
April 30, 2020
Correlation between heart fatty acid binding protein and severe COVID-19: A case-control study
Results from a case-control study of 46 patients indicate that the elevation of heart-fatty acid binding protein (HFABP) is positively correlated to COVID-19 severity in patients, and elevated HFAPB may cause rapid progression in disease severity. Yin et al. (Apr 29, 2020). Correlation between heart fatty acid binding protein and severe COVID-19: A case-control study….
Gender-Based Disparities in COVID-19 Patient Outcomes: A Propensity-matched Analysis
Findings from a retrospective cohort study indicate that males have a higher risk for mortality, hospitalization and mechanical ventilation when compared to a matched cohort of females with similar age, risk behavior, and comorbidities. This gender-based disparity in risk of poor outcomes among COVID-19 patients is especially pronounced in advanced ages. Singh et al. (Apr…
Pregnancy and breastfeeding during COVID-19 pandemic: A systematic review of published pregnancy cases
A systematic review summarizes characteristics and pregnancy outcomes of pregnant women with COVID-19 and highlights that fetal distress and preterm delivery may be more frequent among pregnant women with COVID-19. There is emerging evidence on vertical transmission, but the clinical relevance of fetal infection remains unclear. No evidence links the SARS-CoV-2 virus to transmission via…
Informative Ranking of Stand Out Collections of Symptoms: A New Data-Driven Approach to Identify the Strong Warning Signs of COVID 19
This paper introduces a Conditionally Predictively Informative Ranking (CPIR) approach to analyze COVID-19 symptoms. This approach provides a ranking of informative symptoms that may help in clinical settings and potentially be used for broader public policy discussions. The authors provide multiple combinations of symptoms associated with typical patients, as well as critical and risky symptoms…
April 29, 2020
Long-term Coexistence of SARS-CoV-2 with Antibody Response in COVID-19 Patients
Wang et investigated whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection in 26 COVID-19 patients with mild symptoms in Jinan, China. They report of a subset of patients with both SRAS-CoV-2 and virus-specific IgG coexisting for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient…
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