Result for
Topic: Clinical Characteristics and Health Care Setting
April 22, 2020
Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2
This paper presents a guidance based on best available evidence and expert opinion from a panel of pediatric infectious diseases physicians and pharmacists from 18 geographically diverse North American institutions. It discourages the use of antivirals in most COVID-19 pediatric patients. For children who develop severe or critical disease, this guidance offers approaches for decision-making…
Long-term clinical outcomes in survivors of coronavirus outbreak after hospitalization or ICU admission: a systematic review and Meta-analysis of follow-up studies
Meta-analysis was conducted by Ahmed et al, to determine the long-term clinical problems in adult survivors of COVID-19, SARS and MERS after hospitalization or ICU, using pooled estimates of prevalence and severity for different outcomes and at different time points after follow-up admission. They report that the long term clinical problems in survivors of CoV…
Imaging characteristics of initial chest computed tomography and clinical manifestations of patients with COVID‑19 pneumonia
This paper presents imaging characteristics of initial chest CT and clinical manifestations of patients with COVID‑19 pneumonia. It provides description of the nature of lesions, locations, and severity in different age groups. Single site lesions were observed in patients <35 yrs of age, and multiple sites and extensive area were observed in patients > 60…
Epidemiological and clinical characteristics of 26 asymptomatic SARS-CoV-2 carriers
Pan et al retrospectively analyzed 26 persistently asymptomatic SARS-CoV-2 carriers. They reported that 22 cases (84.6%) correlated with clustering occurrence. The median period from contact to diagnosis and the last positive nucleic acid test was 19 and 21.5 days, respectively. This period was found different between patients with atypical chest CT findings and those with…
April 21, 2020
Specific ACE2 Expression in Small Intestinal Enterocytes may Cause Gastrointestinal Symptoms and Injury after 2019-nCoV Infection
This study summarizes clinical data from four recent studies involving clinical characteristics of COVID-19 to determine the incidence of GI symptoms and explore the potential mechanism of diarrhea and other GI manifestations of disease. Results reveal that ACE mRNA and proteins are highly expressed in the small intestine, which may mediate the invasion and amplification…
Diarrhea is associated with prolonged symptoms and viral carriage in COVID-19
This retrospective analysis of 84 patients with SARS-CoV-2 pneumonia in Wuhan found that duration of fever and shortness of breath in patients with diarrhea was significantly longer than those without, and that patients with diarrhea have a higher proportion of SARS-CoV-2 viral RNA detection in stool. Wei et al. (April 18, 2020). Diarrhea is associated…
Comparing rapid scoring systems in mortality prediction of critical ill patients with novel coronavirus disease
The authors evaluated the performance of the Modified Early Warning Score (MEWS) and Rapid Emergency Medicine Score (REMS) when applied to 138 critically ill COVID-19 patients. REMS was a better predictor of mortality among both age groups (<65 and 65+ years old), and could provide emergency clinicians with an effective adjunct risk stratification tool for…
April 20, 2020
Clinical characteristics of secure acute respiratory syndrome coronavirus 2 reactivation
Ye at al reviewed clinical and lab records, and chest CT scans for 55 patients with lab-confirmed COVID-19 pneumonia admitted to a hospital in Wuhan, 5 of whom presented with SARS-CoV-2 reactivation after hospital discharge. The time from SARS-CoV-2 negative to positive ranged from 4 to 17 days, suggesting that recovered patients may still be…
The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID19 infection
This study found evidence of COVID-19 infection in the nervous, digestive, reproductive, respiratory, circulatory and urine systems using scRNA-Seq data collected from 31 organs from 9 major human systems. The lungs, large intestine, fallopian tube and nose were found to be the most susceptible organs, indicating that SARS-CoV-2 mainly attacks the respiratory, digestive and reproductive…
April 17, 2020
Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study
The authors conducted a retrospective cohort study of COVID-19 patients from a hospital in Wuhan to evaluate the association between platelets and poor outcomes and find that thrombocytopenia at admission was associated with morality of almost three times as high compared to those without thrombocytopenia. Among the 383 patients, 334 (87%) were discharged and 49…
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