Result for
Topic: Clinical Characteristics and Health Care Setting
April 13, 2020
COVID-19 and Diabetes: Knowledge in Progress
Hussain et al reviewed scientific literature for general characteristics of the SARS-CoV-2 to provide a better understanding and management of COVID-19 in diabetic patients. They identified chronic inflammation, increased coagulation activity, immune response impairment, and potential direct pancreatic damage by SARS-CoV-2 as underlying mechanisms. They caution against using chloroquine during hypoglycemic events in patients. From…
Factors associated with hospitalization and critical illness among 4,103 patients with Covid-19 disease in New York City
Petrilli et al examined factors associated with hospitalization and critical illness in Covid-19 positive patients treated at a health system in New York City between March 1 – April 2, 2020. The strongest risk factors for hospitalization identified were: age >65 yrs, BMI>40 and heart failure. Strongest critical illness risks were: admission oxygen saturation <88%,…
April 10, 2020
Radiological findings and clinical characteristics of pregnant women with COVID 19 pneumonia
The authors review CT images and clinical findings from 23 hospitalized pregnant COVID-19 patients (15 asymptomatic, 8 symptomatic). Clinical characteristics and radiological findings in pregnant women with COVID 19 were similar to those of non-pregnant women with COVID-19, and a correlation between clinical and radiological characteristics was observed in this study. Wu et al. (Apr…
Early virus clearance and delayed antibody response in a case of COVID-19 with a history of co-infection with HIV-1 and HCV
Zhao et al report on a COVID-19 case with HIV-1 and HCV co-infection. The case showed persistently negative SARS-CoV-2 RNA tests, but had a delayed antibody response in the plasma, highlighting the influence of HIV-1 induced immunosuppression on early SARS-CoV-2 clearance. Zhao et al. (Apr 9, 2020). Early virus clearance and delayed antibody response in…
Factors associated with prolonged viral RNA shedding in patients with COVID-19
This retrospective study of 113 patients identified risk factors of prolonged viral shedding in COVID-19 patients, including: male sex, delayed admission to hospital after illness onset, and invasive mechanical ventilation. Xu et al. (Apr 9, 2020). Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa351
High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation
The authors analyzed the relationship between clinical characteristics and the need for invasive mechanical ventilation (IMV) in this retrospective cohort study of 124 patients in France. The study showed a high frequency of obesity among patients admitted to intensive care (48%). The need for IMV was associated with male sex and increased BMI, and the…
The Role of Vitamin D in Suppressing Cytokine Storm in COVID-19 Patients and Associated Mortality
Data from over 5,000 confirmed COVID-19 cases from 9 countries are analyzed to investigate a potential association between severe Vitamin D deficiency and age-specific case fatality. The study find that countries with lower Vitamin D levels had higher age-specific case fatality, suggesting that proper Vitamin D supplementation may reduce the number of severe COVID-19 cases…
Pulmonary and Cardiac Pathology in COVID-19: The First Autopsy Series from New Orleans
Fox et al report on relevant cardiopulmonary findings from the first series of autopsies in the US on patients who died from COVID-19. These cases identify key pathologic states potentially contributing to severe disease and decompensation in these patients. Fox et al. (Apr 10, 2020). Pulmonary and Cardiac Pathology in COVID-19: The First Autopsy Series…
April 9, 2020
Electrolyte Imbalances in Patients with Severe Coronavirus Disease 2019 (COVID-19)
This study reports on various electrolyte abnormalities in patients at admission who progressed to the severe form of COVID-19. Lippi et al compared electrolyte (sodium, potassium, chloride, and calcium) levels between COVID-19 patients with and without severe disease, and found that severity may be associated with lower serum concentrations of sodium, potassium and calcium. These…
Neonatal resuscitation and postresuscitation care of infants born to mothers with suspected or confirmed SARS-CoV-2 Infection
Appropriate protection of healthcare workers and newly born infants during and after delivery by a mother with COVID-19 is essential. Chandrasekharan et al outline the precautions and steps to be taken before, during, and after resuscitation of a newborn born to a mother with COVID-19, including three optional variations of current standards involving shared-decision making…
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