Alliance for Pandemic Preparedness

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Topic: Clinical Characteristics and Health Care Setting


April 9, 2020

Clinical Course and Outcomes of 344 Intensive Care Patients with COVID-19

Wang et al discuss the clinical care of 344 intensive care patients in a hospital in China. They cover the demographic, clinical, laboratory and radiologic findings, and treatment and outcome data from electronic medical records. This information is important for clinicians managing ICU patients. Wang et al. (April 8, 2020). Clinical Course and Outcomes of…


Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain

Tagarro et al discuss the clinical features of children tested for SARS-CoV-2 in Madrid, Spain. They examined children’s gender, contact history, severity of infection, case management and comorbidity. This information is useful for those managing COVID-19 in children. Tagarro et al. (April 8, 2020). Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in…


PCR Assays Turned Positive in 25 Discharged COVID-19 Patients

Yuan et al report on the laboratory and clinical characteristics of 25 patients in China who met hospital criteria for discharge, yet remained carriers of SARS-CoV-2 after recovery from COVID-19. They suggest that two negative RT-PCR tests 24 hours apart may not be sufficient for viral clearance evaluation, and recommend repeating RT-PCR testing at least…


April 8, 2020

N95 Mask Decontamination using Standard Hospital Sterilization Technologies

The response to the COVID19 epidemic is generating severe shortages of N95 respirator masks around the world. Kumar et al tested the ability of 4 different decontamination methods on 4 different N95 masks and observed if repeated cycles of decontamination would preserve their structural and functional integrity.  A standard autoclave treatment was the best with…


April 7, 2020

Immune-epidemiological parameters of the novel coronavirus – a perspective.

This article discusses the epidemiological dynamics of COVID-19 with the aim of understanding the ability and inability of the immune system to combat COVID-19. Transmission may be influenced by the host-related factors that are known to be associated with immune dysregulation. The article also mentions that finding immune biomarkers that can distinguish severe-to-critical from mild-to-moderate…


Impact of the COVID-19 pandemic on Parkinson’s disease and movement disorders.

This article mentions that the comorbid diagnosis of Parkinson’s disease (PD) or other movement disorders has not emerged as specific risk factor for negative outcomes of COVID-19. The medical strategy for safety of patients with PD is the same as the strategy for the general elderly population.  Papa et al. (Apr 6, 2020). Impact of…


Epidemiology and Clinical Features of Coronavirus disease 2019 in Children

Choi et al summarize the epidemiological and clinical features of COVID-19 in children to-date, reiterating that while children make up a small fraction of COVID-19 cases and present most often with mild symptoms, some mild cases may progress to severe disease or death. Newborns are also susceptible and may play a role in community transmission. …


April 6, 2020

Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients

Herold et al found a strong association between elevated interleukin-6 (IL-6) and the need for mechanical ventilation in 40 hospitalized patients. The patients did not differ in age, comorbidities, radiological findings, respiratory rate of qSofa score.  This suggests that IL-6 is an effective marker that could be used by physicians to predict upcoming respiratory failure…


Coronavirus Disease 2019 in Children—United States, February 12-April 2, 2020

The CDC COVID-19 Response Team reviewed lab confirmed pediatric cases of COVID-19 in the U.S. during February 12-April 2 and compared it to data on adults aged 18-64 years. Of the 149,082 (99.6%) cases for which age was known, 1.7% were among children under 18 years old and the median age was 11 years. Among…


April 3, 2020

Population based estimates of comorbidities affecting risk for complications from COVID-19 in the US

2017 national BRFSS data indicates that 45% of adults in the US are at potentially heightened risk of complications from COVID-19 due to having at least 1 of 6 co-morbidities (cardiovascular disease, chronic obstructive pulmonary disease, diabetes, asthma, hypertension, and cancer excluding skin).  While these rates increase with age group to about 80% among those…



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