Result for
Topic: Clinical Characteristics and Health Care Setting
March 27, 2020
Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients.
Findings from this retrospective study of 511 COVID-19 patients suggest that elderly (age 65+) patients with hypertension (HT) who are taking ARB anti-HT drugs may be less likely to develop severe lung disease when compared to patients taking no anti-HT drugs. Liu et al. (Mar 27, 2020). Anti-hypertensive Angiotensin II receptor blockers associated to mitigation…
Are patients with inflammatory bowel disease at increased risk for Covid-19 infection?
The authors discuss the theoretical biological mechanisms which could put inflammatory bowel disease patients at risk, with inflamed gut tissue representing an optimal doorway for viral entry. However, no published evidence suggest that COVID-19 occurs more frequently in IBD patients, and no IBD patients with SARS-CoV-2 infection were reported in Wuhan. Monteleone and Ardizzone (Mar…
Acute gastrointestinal injury in critically ill patients with coronavirus disease 2019 in Wuhan, China.
This clinical retrospective study of 83 critically ill COVID-19 patients found high rates of acute gastrointestinal injury (AGI) (87%) and hospital mortality (48%). Organ failure, white blood cell counts, and duration of mechanical ventilation were risk factors for grade II AGI and above. Patients with worse AGI had worse clinical severity, higher septic shock incidence,…
March 26, 2020
The different clinical characteristics of corona virus disease cases between children and their families in China – the character of children with COVID-19.
This study presents clinical characteristics of COVID-19 from 9 children and their families, indicating that new control measures should include rapid medical assessment and removal of cases from home and increased awareness of the importance of protective measures after symptom onset. Su et al. (Mar 25, 2020). The different clinical characteristics of corona virus disease…
Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China.
In this cohort study of 416 patients from 1 hospital in Wuhan, the authors find that cardiac injury was a common condition among patients hospitalized with COVID-19 and was associated with a higher risk of in-hospital mortality. Although the exact mechanism of cardiac injury needs to be further explored, the findings highlight the need to…
Analysis of Epidemiological and Clinical features in older patients with Corona Virus Disease 2019 (COVID-19) out of Wuhan.
This retrospective study of 788 COVID-19 patients, 136 of whom were older patients (60+ years), from Wuhan describes the specific epidemiological and clinical features of older COVID-19 patients. The study finds that these older patients were more likely to: be female gender; have high body temperature; show familiar clustering; have co-existing basic diseases, dyspnea, or…
March 25, 2020
Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study.
Yu et al review findings from 7 pregnant COVID-19 patients in Wuhan, China with a focus on clinical features and obstetric and neonatal outcomes. Clinical characteristics of these patients infected late in pregnancy were similar to those of non-pregnant adults, and maternal, fetal, and neonatal outcomes all appeared to be very good because of intensive…
Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.
In this cross-sectional study of 25 pediatric patients in Hubei province, China, the authors find that while children were still susceptible to COVID-19, the clinical presentations and outcomes were mostly favorable when compared to adults. Extra attention during home-care and hospitalization treatment may be needed in the younger age-group that accounted for majority of the…
March 24, 2020
Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases
WHO interim guidelines recommend offering extracorporeal membrane oxygenation (ECMO) to eligible patients who develop severe ARDS associated with COVID-19. Given the practical restraints of substantially increasing the global availability of ECMO services during the COVID-19 pandemic, it is important to consider other evidence-based treatment options for severe ARDS patients. Kollengode et al. (Mar 20, 2020)….
Systematic review of COVID-19 in children show milder cases and a better prognosis than adults
A systematic review of 45 relevant articles showed that children have accounted for 1-5% of documented COVID-19 cases and have experienced milder disease and better prognosis than adults. A case report describes the symptoms, clinical course and treatment of 3 hospitalized children (ages 6 and 8 years and 6 months) who recovered from COVID-19. Ludviggson…
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