Result for
Topic: Clinical Characteristics and Health Care Setting
February 28, 2020
Positive RT-PCR test results in patients recovered from COVID-19
Four recovered patients with COVID-19 who met criteria for hospital discharge or discontinuation of quarantine in China were evaluated with RT-PCR tests for COVID-19 nucleic acid to determine if they could return to work. All had positive RT-PCR test results 5 to 13 days later which suggests a need to reevaluate current criteria for hospital…
Essentials for Radiologists on COVID-19: An Update—Radiology Scientific Expert Panel
An update by a radiology scientific expert panel in the US reviewed current COVID-19 diagnostic tools for limitations. They report that up to 50% of patients may have normal CT scans 0-2 days after onset, 50%-75% of patients may have lung abnormalities early in disease progression, and that RT-PCR sensitivity may be as low as…
The ACE2 expression of maternal-fetal interface and fetal organs indicates potential risk of vertical transmission of SARS-COV-2
Li et al (2020) conducted an investigation into the capacity of vertical transmission of SARS-CoV-2 using Angiotensin-converting enzyme 2 (ACE2), a confirmed receptor of SARS-CoV-2 that plays essential roles in human infection and transmission. They used an open source online single-cell RNA sequencing data, to evaluate the cell specific expression of ACE2 in maternal-fetal interface…
Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know
Rasmussen et al reviewed two reports describing 18 pregnant women with COVID-19 that were infected in the third trimester. They reported clinical findings were similar to those in non-pregnant adults. Fetal distress and preterm delivery were seen in some cases. All but two pregnancies were cesarean deliveries, and testing for SARS-CoV-2 was negative on all…
Clinical Characteristics of Coronavirus Disease 2019 in China
Guan et al reviewed clinical data from 1,099 lab-confirmed COVID-19 patients in China. They describe their composite end points, human and animal contacts, clinical symptoms, and radiological and laboratory diagnoses. They report that patients often presented without fever at admission (56.2%) and hospitalization (11.3%) and many did not have abnormal radiologic findings, a tool primarily…
February 27, 2020
De-isolating COVID-19 Suspect Cases: A Continuing Challenge
Tay et al. discuss the challenges of de-isolating COVID-19 suspect cases in Singapore. They report that no single indicator may be effectively used to decide on de-isolation of suspect cases. They provide criteria for de-isolation for COVID-19 suspect cases and conclude that a rigorous framework is required to help clinicians de-isolate COVID-19 patients safely. Tay…
Clinical Features of COVID-19 -Related Liver Damage
Fan et al. warn medical practitioners that COVID-19 may cause liver damage, so treatment with Lopinavir/ritonavir should be administered with caution. Fan et al. (Feb 27, 2020). Clinical Features of COVID-19 -Related Liver Damage. Pre-print downloaded Feb 27 from https://doi.org/10.1101/2020.02.26.20026971
Clinical and radiographic features of cardiac injury in patients with 2019 novel coronavirus pneumonia
Hui and team investigated risk of cardiac injury in patients with 2019 novel coronavirus pneumonia. They reported that cardiac injury was rare among light and mild patients, while common in severe and critical patients. They recommend monitoring heart function in COVID-2019 patients and applying potential interventions for those with abnormal cardiac injury related characteristics. Hui…
Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis
He et al. evaluated the spectrum of comorbidities and its impact on the clinical outcome in patients with coronavirus disease 2019 (COVID-19). They report comorbidities were present in 25% of patients with COVID-19 in China and were associated with poorer clinical outcomes. He et al. (Feb 27, 2020). Comorbidity and its impact on 1,590 patients…
Correlation Analysis between Disease Severity and Inflammation-related Parameters in Patients with COVID-19 Pneumonia
Gong et al. analyzed correlation between disease severity and inflammation-related parameters in patients with COVID-19 pneumonia. They analyzed blood inflammation indicators among mild, severe, and critical patients, to help identify severe or critical patients early. They report age, interleukin-2 receptor, C-reactive protein, Ferro-protein, white blood cell and lymphocyte counts should be closely observed. IL-6, TNFα…
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