Alliance for Pandemic Preparedness

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Topic: Clinical Characteristics and Health Care Setting


February 26, 2020

Coronavirus Disease 2019 (COVID-19): A Perspective from China

Authors present the role of radiology in responding to the current COVID-19 outbreak through early detection and assessment of disease course.  Zu et al. (Feb 21, 2020). Coronavirus Disease 2019 (COVID-19): A Perspective from China. Radiology. https://doi.org/10.1148/radiol.2020200490


Rules on isolation rooms for suspected covid-19 cases in GP surgeries to be relaxed

This commentary reviews practical considerations for isolation and quarantine in the healthcare setting for suspected, but not confirmed, COVID-19 cases.  Zosia (Feb 21, 2020). Rules on isolation rooms for suspected covid-19 cases in GP surgeries to be relaxed. BMJ. https://www.bmj.com/content/bmj/368/bmj.m707.full.pdf 


Staff safety during emergency airway management for COVID-19 in Hong Kong

Specific recommendations and considerations are provided for administering respiratory support that maximizes patient wellness and staff safety. Cheung et al. (Feb 24, 2020). Staff safety during emergency airway management for COVID-19 in Hong Kong. Lancet Respir Med. https://doi.org/10.1016/S2213-2600(20)30084-9 


Clinical characteristics of 50466 patients with 2019-nCoV infection

This meta-analysis of clinical studies on COVID-19 included 50,466 patients. In addition to previously reported symptoms, 18.1% of cases were deemed severe and case fatality was 4.3%.  Sun et al. (Feb 25, 2020). Clinical characteristics of 50466 patients with 2019-nCoV infection. Pre-print downloaded Feb 25 from https://doi.org/10.1101/2020.02.18.20024539


Higher severity and mortality in male patients with COVID-19 independent of age and susceptibility.

While men and women appear to be equally susceptible to COVID-19, men tend to have more severe illness, similar to SARS-CoV. Older age and more comorbidities were also associated with higher COVID-19 illness severity in this review of public data from China.   Jin et al. (Feb 25, 2020). Higher severity and mortality in male patients…


Generation of antibodies against COVID-19 virus for development of diagnostic tools

Researchers describe novel efforts to generate polyclonal and monoclonal COVID-19 antibodies and test a potential serologic diagnostic tool.  Li et al. (Feb 25, 2020). Generation of antibodies against COVID-19 virus for development of diagnostic tools. Pre-print downloaded Feb 25 from https://doi.org/10.1101/2020.02.20.20025999. 


2019 novel coronavirus disease in hemodialysis (HD) patients: Report from one HD center in Wuhan, China

Authors describe a COVID-19 outbreak in a hemodialysis center in Wuhan that began Jan 14 and ended fully on Feb 17. Upgrading prevention and protection procedures and starting universal screening and isolation were effective in controlling the outbreak. Overall, this appears to be a highly susceptible population that may be particularly vulnerable to cardiovascular events…


Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China

Two clinicians reviewed clinical records, lab findings, and radiologic data of 25 COVID-19 deaths at one Wuhan hospital. Overall, older age and underling diseases were common among decedents. Average disease duration 10.56 days (SD 4.42 days). All patients died of respiratory failure and all had underlying diseases: hypertension (64%), diabetes (40%), heart disease (32%), kidney…


The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals

Zhu et al. discuss several factors that may increase the risk of COVID-19 transmission in psychiatric in-patient settings and offer recommendations that may help mitigate the effects of an outbreak.  Zhu et al (Feb 25, 2020). The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals. Neuroscience Bulletin. https://doi.org/10.1007/s12264-020-00476-9


Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study

Clinical data were reviewed for 214 hospitalized patients with COVID-19 at three designated care hospitals in Wuhan to evaluate the presence of neurological symptoms.  Overall, 36.4% of patients had neurologic manifestations, though they were more common among those with severe illness, including acute cerebrovascular diseases, consciousness impairment, and skeletal muscle symptoms. Mao et al. (Feb…



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