Result for
Topic: Clinical Characteristics and Health Care Setting
February 26, 2020
SARS-CoV-2 transmission in cancer patients of a tertiary hospital in Wuhan
1,524 cancer patients were evaluated from Dec 30-Feb 17, of whom 12 developed COVID-19, representing a two-fold greater risk than the general population. Only five of these patients were undergoing cancer treatment, suggesting that hospital visits were likely the most relevant risk factor. Severe illness was not higher than in the general population. Considerations for…
February 25, 2020
Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
Lim et al. track the origin of SARS-CoV-2 infections in South Korea. They report on clinical findings and case management of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed. Lim…
Rapid Detection of Novel Coronavirus (COVID-19) by Reverse Transcription-Loop-Mediated Isothermal Amplification
Quantitative reverse transcription PCR (qRT-PCR) is currently the standard for COVID-19 detection; however, Reverse Transcription Loop-Mediated Isothermal Amplification (RTLAMP) may allow for faster and cheaper field based testing at point-of-risk. RT-LAMP can be performed in under 30 mins and specifically detected COVID-19 in simulated patient samples. The test has potential for use in monitoring of…
Viral load of SARS-CoV-2 in clinical samples
The authors report viral dynamics in clinical specimens (throat swabs, sputum, urine, and stool) of 82 COVID-19 patients using N-gene-specific quantitative RT-PCR assay. The findings from viral loads and peak periods of virus in different samples are reported. The timelines when the patients are infectious and when and what type of samples to take for…
Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea
Kim et al. report that data on viral load kinetics in confirmed cases are lacking. They present distinct viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea. The findings suggest that viral load kinetics of SARS-CoV-2 may be different from that of other coronavirus infection. Kim et al….
First respiratory transmitted food borne outbreak?
In the absence of any findings from known animal source of human novel coronavirus (SARS-CoV-2) infection, Jalava (2020) reports that wide contamination of seafood (seafood and fish tanks) and wildlife markets might explain the initiation of the SARS-CoV-2 outbreak. A comparative study of genetic sequences will not be adequate to resolve and provide credible evidence…
First Atypical case of 2019 novel coronavirus in Yan’an, China
Hao et al report on an atypical COVID-19 case in a 60 -year old man manifesting mainly as fatigue. The patient did not have fever or respiratory symptoms. Diagnosis was confirmed by epidemiological characteristics, chest imaging, and lab findings. There is need to expand case definition for better case management and understanding of epidemiology of…
February 24, 2020
Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2) infected pneumonia (COVID-19)
Sputum specimens appear to be more sensitive than throat swabs in detecting COVID-19, though authors do not provide estimates of positive predictive value. Lin et al. (Feb 23, 2020). Comparison of throat swabs and sputum specimens for viral nucleic acid detection in 52 cases of novel coronavirus (SARS-Cov-2) infected pneumonia (COVID-19). Pre-print downloaded Feb 23…
Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis
Authors offer COVID-19 safety considerations for the practice of dentistry. Sabino-Silva et al. (Feb 20, 2020). Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis. Clinical Oral Investigations. https://doi.org/10.1007/s00784-020-03248-x
From Isolation to Coordination: How Can Telemedicine Help Combat the COVID-19 Outbreak?
This commentary describes the potential role of telemedicine in COVID-19 response efforts. Zhai et al. (Feb 23, 2020). From Isolation to Coordination: How Can Telemedicine Help Combat the COVID-19 Outbreak? Pre-print downloaded Feb 23 from https://doi.org/10.1101/2020.02.20.20025957
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