Result for
Topic: Clinical Characteristics and Health Care Setting
February 20, 2020
Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia: Brief Report
The team at the hematology and clinical lab in Tongli Hospital China report significantly abnormal coagulation parameters that are associated with poor prognosis in patients with COVID-19 pneumonia. Tang et al. (Feb 19, 2020). Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia: Brief Report. Journal of Thrombosis and Haemostatis….
Critical care response to a hospital outbreak of the 2019-nCoV infection in Shenzhen, China
Liu et al. outline critical care response in a recent hospital outbreak of COVID-19 in Shenzhen, China. Liu et al. (Feb 19, 2020). Critical care response to a hospital outbreak of the 2019-nCoV infection in Shenzhen, China. Critical Care. https://doi.org/10.1186/s13054-020-2786-x
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies
Gao et al. report that Chloroquine phosphate (an antimalarial drug) has apparent efficacy in treatment of COVID-19 associated pneumonia in multicenter clinical trial studies in China. The drug is now recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the…
Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR
Fang et al. investigated sensitivity of chest CT for COVID-19 in early diagnosis of disease. RT-PCR was used as gold standard and were conducted using throat swabs (45 patients) or sputum samples (6 patients) of 51 patients. Sensitivity of chest CT was greater than that of RT-PCR (98% vs 71%, respectively, p<.001). Limitation of RT-PCR…
February 19, 2020
Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China
This brief letter provides clinical characteristics and outcomes for all 9 infants hospitalized in China with COVID-19. Wei et al. (Feb 14, 2020). Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China. JAMA. https://jamanetwork.com/journals/jama/fullarticle/2761659
Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics
Fever clinics for triaging patients were an effective strategy during the 2003 SARS epidemic. The authors offer clinical strategies for operating adult fever clinics during the current COVID-19 outbreak. Zhang et al. (Feb 13, 2020). Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics. The Lancet. https://doi.org/10.1016/S2213-2600(20)30071-0
Can Chinese Medicine Be Used for Prevention of Corona Virus Disease 2019 (COVID-19)? A Review of Historical Classics, Research Evidence and Current Prevention Programs
Hui and colleagues conducted a review of the literature on the use of Chinese medicine for the prevention and treatment of SARS and H1N1, including 7 studies overall. The most commonly used herbal treatments are described along with the results of these studies which generally indicated protective effects of these treatments. Recommendations for future testing…
The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) — China, 2020
China CDC has published descriptive clinical information for 72,314 patients, including 44,672 confirmed, 16,186 suspected, and 10,567 clinically diagnosed, and 889 asymptomatic cases of COVID-19. 1,023 deaths occurred among confirmed cases (2.3%). The article includes descriptive information of cases and multiple epidemic curves, showing a peak in symptom onset in Hubei from Jan 23-26. China…
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes
Biological samples taken from 15 COVID-19 patients in one Chinese hospital were tested for the presence of 2019-nCoV. Oral samples tested positive in only half of patients, 4 had positive anal swabs, 6 had positive blood samples, and 3 were also serum positive. A second analysis suggests that oral swabs tend to test positive more…
Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients
Peripheral blood samples were collected longitudinally from 40 confirmed COVID-19 cases and evaluated for lymphocyte subsets and cytokine profiles. Severe cases had more sustained lymphocyte depletion but increased neutrophil counts compared to mild cases. T cell counts were also decreased among severe cases. The neutrophil-to-CD8+ T cell ratio may be a useful prognostic tool for…
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