Result for
Topic: Clinical Characteristics and Health Care Setting
February 7, 2020
2019-nCoV epidemic: what about pregnancies?
This brief correspondence provides some considerations for 2019-nCov infection, diagnosis, and treatment during pregnancy based on experiences with MERS-CoV and SARS-CoV. Favre et al. (Feb 6, 2020). 2019-nCoV epidemic: what about pregnancies? The Lancet. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30311-1/fulltext
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China
Clinical characteristics of 138 hospitalized patients with confirmed 2019-nCoV at a single hospital are described, comparing across ICU status. The symptom profile is comparable to other case series reports. As expected, comorbidities, complications, and various treatment procedures were more common among ICU patients, who were also older on average than non-ICU patients. Wang et al….
Persons Evaluated for 2019 Novel Coronavirus — United States, January 2020
CDC compiled information from ~650 state reports and inquiries regarding persons under investigation (PUI) for 2019-nCov through Jan 31. Clinical characteristics, epidemiologic risk classification, setting where patient was identified, and testing results are presented. Of the 210 people tested, 11 (5%) tested positive for 2019-nCoV and 9 of these had travel history to Wuhan. The…
February 6, 2020
Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist
Kanne reviews the current literature on chest image findings for patients with 2019-nCoV lung infections. Overall, the current review finds similarities in chest imaging among 2019-nCoV, SARS-CoV, and MERS-CoV patients The review supports the common radiograph finding of bilateral lung consolidation. Small pleural effusions may be a sign of worsening clinical condition. From a case…
February 5, 2020
Specific ACE2 Expression in Cholangiocytes May Cause Liver Damage After 2019-nCoV Infection
Liver function abnormalities have been observed in some 2019-nCoV patients. Chai, et al. assess potential pathways for this damage given the presumed role ACE2 expression in 2019-nCoV infection. They found liver abnormalities of 2019-nCoV patients could involve cholangiocyte dysfunction more than hepatocyte damage. Drug induced and systemic inflammatory response may also have a role. Chai…
February 4, 2020
Early epidemiological analysis of the 2019-nCoV outbreak based on a crowdsourced data
Context: Based on current reports from China, the case fatality (%) among confirmed cases since the start of the epidemic is 2.1% (15% among “severe” cases; 1% among all confirmed and suspected cases). Sun, et al. used crowdsourced data from a Chinese healthcare professional community network site and other publicly available data to provide information…
February 3, 2020
Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam
This article provides additional information on a father-son pair from Vietnam, reported earlier The father was a 65 year-old with a history of hypertension, type 2 diabetes, coronary heart disease, and lung cancer. He became ill with fever on 17 January, 2020, and was admitted to hospital through the ED on 22 January. His condition…
January 31, 2020
Potential inhibitors for 20192019-nCoV coronavirus M protease from clinically approved medicines
An assessment of commercially available medications found up to 10 that may be useful in treating 2019-nCoV. Liu and Wang (Jan 29, 2020). Potential inhibitors for 20192019-nCoV coronavirus M protease from clinically approved medicines. Pre Print. https://www.biorxiv.org/content/10.1101/2020.01.29.924100v1
January 30, 2020
Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China
Updated descriptive epidemiology is provided for the outbreak. While the authors provide an estimated case fatality of 2.84% overall, this was calculated from an outdated estimate of 1,975 cases in mainland China. The first 17 deaths reported by the China national Health Commission are described clinically. The majority (13/17) were male with median age of…
January 29, 2020
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
All 99 cases identified from Jan 1 – Jan 20, 2020 at a single Wuhan hospital confirmed by RT-PCR are described. Patients who died aligned with the MuLBSTA score for predicting mortality in viral pneumonia. 49% had exposure to the Huanan seafood market 51% had chronic diseases Clinical manifestations: fever (83%), cough (82%), shortness of…
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