Alliance for Pandemic Preparedness

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Topic: Clinical Characteristics and Health Care Setting


February 10, 2020

Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China

Clinical characteristics of 15 2019-nCoV patients outside of Wuhan are described.  Chang et al. (Feb 7, 2020). Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China. JAMA Research Letter. https://jamanetwork.com/journals/jama/fullarticle/2761043?resultClick=1


CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia

CT imaging for two 2019-nCoV patients demonstrate changes over the duration of disease. Fang et al. (Feb 7, 2020). CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia. Radiology. https://pubs.rsna.org/doi/10.1148/radiol.2020200280


Evolving status of the 2019 novel coronavirus Infection: proposal of conventional serologic assays for disease diagnosis and infection monitoring

Researchers explain the need for developing serological assays for 2019-nCoV testing. Real-time RT-PCR or next-generation sequencing are the primary methods for confirming 2019-nCoV infection, but with limited supplies, the number of cases that can be tested is restricted and delayed. Researchers propose conventional serological assays as a potential alternative.  A backlog of tests in China…


Clinical characteristics of 2019 novel coronavirus infection in China

Clinical characteristics of 1,099 laboratory-confirmed 2019-nCoV patients at 552 hospitals across China (through Jan 29) are described in relation to disease severity and a composite endpoint of ICU admission, mechanical ventilation, and death. Disease severity (including oxygen saturation, respiratory rate, blood leukocyte/lymphocyte count, and chest X-ray/CT manifestations) predicts clinical outcomes Median age of 47 years…


The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China: Implication for Infection Prevention and Control Measures

In reviewing the importation of the first 2019-nCoV case to Korea, clinicians call for testing all symptomatic individuals with epidemiologic risk for 2019-nCoV rather than waiting for pneumonia or other symptoms to develop. They describe potential flaws of relying on chest radiography and clinical cues, urging clinicians to prioritize travel history to improve early detection…


February 7, 2020

Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue

Clinical features of 28 pediatric 2019-nCoV patients are described.  Age range 1 month – 17 years, all associated with family clusters. Several patients had no obvious clinical symptoms but were identified as part of close contact screening. Most had mild symptoms without fever or pneumonia. No severe cases or deaths have been reported. Shen and…


Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus

Researchers and clinicians in China and Zhejiang Province developed recommendations for the diagnosis and treatment of 2019-nCoV in children. They provide child-specific diagnostic criteria and considerations for newborns.  Clinical presentation appears similar to adults: Pediatric patients generally present with fever, fatigue, and cough, and sometimes with congestion, runny nose, expectoration, diarrhea, headache, and other symptoms. …


Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China

ICU physicians in Sichuan Province developed a preparedness and response plan for handling severe cases of 2019-nCoV. They provide metrics for assessing patients and ensuring the health and safety of clinical and hospital staff. Liao et al. (Feb 5, 2020). Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province,…


Emerging Coronavirus 2019-nCoV Pneumonia

Song et al. provide an overview of imaging results for 51 confirmed 2019-nCoV cases.  Song et al. (Feb 6, 2020). Emerging Coronavirus 2019-nCoV Pneumonia. Radiology. https://pubs.rsna.org/doi/10.1148/radiol.2020200274


Imaging changes in patients with 2019-nCov

Changes in chest CT from initial diagnosis with 2019-nCoV to subsequent imaging are described for patients at one hospital. Pan and Guan (Feb 6, 2020). Imaging changes in patients with 2019-nCov. European Radiology. https://doi.org/10.1007/s00330-020-06713-z 



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