Result for
Topic: Testing and Treatment
February 11, 2021
Citywide Serosurveillance of the Initial SARS-CoV-2 Outbreak in San Francisco
[Pre-print, not peer reviewed] SARS-CoV-2 serosurveillance using remnant samples from routine blood draws in two major hospital networks in San Francisco estimated a seroprevalence of 4.2% in the period between March and June 2020. Seroprevalence was higher among those who were uninsured; individuals identifying as Hispanic, Black, or African; males; and individuals who experience homelessness….
Detection Of Genomic Variants Of SARS-CoV-2 Circulating In Wastewater By High-Throughput Sequencing
[Pre-print, not peer reviewed] Analysis of 40 Spanish wastewater samples obtained between April and October 2020 identified three variants with mutations in the spike protein not previously detected elsewhere and 7 non-synonymous spike protein mutations not previously detected in Spain. Three of these 7 mutations have been found at low frequencies in sequencing of genomes…
February 10, 2021
SARS-CoV-2 Infection Is Effectively Treated and Prevented by EIDD-2801
Mice implanted with human lung tissue may serve as an effective animal model to investigate SARS-CoV-2 infection and to test potential treatments and preventive agents. A study of human lung-only mice (LoM) showed that this platform can be used to study SARS-CoV-2 infection in vivo in ways that allows direct comparison of outcomes between mice…
Major Update: Remdesivir for Adults With COVID-19
Updates from a living systematic review and meta-analysis of remdesivir for adults with COVID-19 indicated that remdesivir likely results in little to no mortality difference (RR=0.93, n=4 randomized trials), but potentially improves the percentage recovered and may result in a small reduction in the proportion receiving ventilation (RR=0.71, n=3 randomized trials). Compared to a 10-day…
Disparities in SARS-CoV-2 Testing in Massachusetts During the COVID-19 Pandemic
A cohort study of SARS-CoV-2 testing intensity (defined as number of weekly tests per 100,000 people) and epidemic intensity (defined as weekly test positivity) in Massachusetts from May 27 to October 14, 2020 showed that testing resources were disproportionately allocated to more affluent communities. In a multivariable model, the relative testing gap increased by 9%…
February 8, 2021
Remdesivir for Treatment of COVID-19; an Updated Systematic Review and Meta-Analysis
A systematic review and meta-analysis of remdesivir for the treatment of COVID-19 showed that data from randomized controlled trials (n=5 trials) indicated significant improvement in the 28-day recovery rate, need for low flow oxygen support through day 14, and mechanical ventilation or extracorporeal membrane oxygenation requirement through days 14 to 28 of follow-up in the…
Impact of Systemic Corticosteroids on Hospitalized Patients with COVID-19 January 2021 Meta-Analysis of Randomized Controlled Trials
[Pre-print, not peer-reviewed] A meta-analysis of five peer-reviewed randomized controlled trials (n = 7,645 patients) of systemic corticosteroid treatment for COVID-19 showed no overall difference in survival among hospitalized patients who received systemic corticosteroid therapy compared to usual care or placebo (OR = 0.82, 95% CI 0.64 – 1.05). Subgroup analysis of 1,967 critically ill…
Implementation of an In-House Real-Time Reverse Transcription-PCR Assay for the Rapid Detection of the SARS-CoV-2 Marseille-4 Variant
[Pre-print, not peer-reviewed] A study evaluating an in-house, real-time RT-PCR (qPCR) assay to detect a SARS-CoV-2 variant with an S477N substitution in the receptor binding domain associated with increased binding affinity to ACE2 found that the assay reliably detected this variant. All 6 cDNA samples from the variant strains tested positive using the assay, whereas…
Genetic Conservation of SARS-CoV-2 RNA Replication Complex in Globally Circulating Isolates and Recently Emerged Variants from Humans and Minks Suggests Minimal Pre-Existing Resistance to Remdesivir
A study analyzing the genetic diversity of the RNA replication complex that is targeted by the antiviral drug remdesivir in a large set of human SARS-CoV-2 isolates (n > 90,000), including the B.1.1.7 and 501.V2 variants and mink isolate (n>300) sequences, found that previously-identified amino acid substitutions that caused reduced susceptibility to remdesivir in-vitro were…
Rapid Electrochemical Detection of Coronavirus SARS-CoV-2Rapid Electrochemical Detection of Coronavirus SARS-CoV-2
A study describing an electrochemical biosensor based on multiplex rolling circle amplification (RCA, in which a short DNA or RNA primer is amplified to make a long single strand) to detect the N and S genes of the SARS-CoV-2 virus showed that the assay could detect as few as 1 copy/microliter of the genes in…
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