Result for
Topic: Testing and Treatment
November 6, 2020
Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
A randomized, open-label, phase 3 trial of remdesivir in hospitalized patients who did not require mechanical ventilation showed that there was no significant difference between a 5-day versus a 10-day course of treatment on the outcome of clinical status on a 7-point scale at day 14 in patients with confirmed SARS-CoV-2 infection. The authors note…
November 4, 2020
Association of COVID-19 RT-QPCR Test False-Negative Rate with Patient Age Sex and Time since Diagnosis
[Preprint, not peer-reviewed] A study using electronic health records in Israel reported that the 11% of PCR tests for SARS-CoV-2 were negative with 0-5 days of clinical diagnosis among patients who had at least one positive PCR test (n= 521,696). Patients who were female (vs. male: OR=1.7) and patients who were younger (10 vs. 40…
SARS-CoV-2 Detection by Nasal Strips a Superior Tool for Surveillance of Pediatric Populations
In pediatric patients, the use of small strips inserted into each nostril was shown to have a sensitivity of 94% and specificity of 100% for the detection of SARS-CoV-2 when compared to pooled nasopharyngeal swab and throat swab samples. Viral loads of SARS-CoV-2 RNA were similar between paired nasal strip samples and nasal swab samples….
November 3, 2020
Outcomes of Contact Tracing in San Francisco, California—Test and Trace During Shelter-in-Place
From April 13 to June 8, San Francisco’s contact tracing program was able to reach 85% (1,394 out of 1,633) of reported cases and subsequent contacts and secondary cases for interviews. People who identified as Latino represented a majority of these cases, despite comprising 15% of San Francisco residents. The secondary household attack proportion (percentage…
November 2, 2020
Norwich COVID-19 Testing Initiative Pilot: Evaluating the Feasibility of Asymptomatic Testing on a University Campus
A cross-sectional study in a university setting in England indicated that universal, repeated self-testing for COVID-19 using PCR was both acceptable, and could be feasible. Staff and student participants (n = 1053) were given four PCR swabs to self-administer over 2 weeks. 76% participants provided at least one swab, among whom 86% provided all four….
Residual SARS-CoV-2 RNA in Nasal Swabs of Convalescent COVID-19: Is Prolonged Quarantine Always Justified?
Residual SARS-CoV-2 RNA load was not substantially associated with ongoing virus replication in a prospective, multicenter observational study of residual RNA load. Nasal swab samples were collected from patients (n = 387) who clinically recovered from COVID-19. The median quantification cycle (Cq) was 37.0, and overall, 2.3% of RT-PCR positive samples with low or very…
October 30, 2020
Novel SARS-CoV-2 Whole-Genome Sequencing Technique Using Reverse Complement PCR Enables Fast and Accurate Outbreak Analysis
[Pre-print, not peer-reviewed] A novel reverse complement polymerase chain reaction (RC-PCR) technology for whole genome sequencing of SARS-CoV-2 was evaluated as a means of supporting SARS-CoV-2 monitoring by potentially saving time and resources. RC-PCR whole genome sequencing showed a genome coverage of up to 98.2% for samples with a maximum Ct value of 32. Six…
October 29, 2020
Inhaled Corticosteroids and COVID-19 Risk and Mortality: A Nationwide Cohort Study
Use of inhaled corticosteroids (ICS) among patients with COPD or asthma was not associated with a COVID-19 diagnosis in a nationwide study conducted in Korea. In a nested case control study among patients with COPD with 640 COVID-19 cases and 2560 matched controls without COVID-19, ICS use was not associated with COVID-19 (aOR=1.02, 95% CI,…
October 28, 2020
Declining Prevalence of Antibody Positivity to SARS-CoV-2 a Community Study of 365000 Adults
[Pre-print, not peer reviewed] Results from 3 non-overlapping cohorts in the UK demonstrated that the overall prevalence of detectable IgG antibodies against SARS-CoV-2 declined by 27% (from 6.0% to 4.4%) between late June and September 2020. Greater levels of decline were seen among older people aged 75+ years (-39%) compared to those 18-24 years old…
Saliva Is a Promising Alternative Specimen for the Detection of SARS-CoV-2 in Children and Adults
[Pre-print, not peer reviewed] Paired testing between nasopharyngeal swab (NPS) and saliva samples from 300 patients (including both pediatric and adult patients) showed that the concordance of saliva and NPS samples was 91.0% and 94.7%, respectively. The positive percent agreement was 81.4% (79/97) and 89.7% (87/97), respectively. The authors suggest that saliva can be an…
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