Result for
Topic: Transmission
February 13, 2020
A Locally Transmitted Case of SARS-CoV-2 Infection in Taiwan
The first known case of 2019-nCoV (labeled here as SARS-CoV-2) local transmission in Taiwan is reported along with CT chest imaging. The case occurred after close contact (spouse) with a known imported case. Liu et al. (Feb 12, 2020). A Locally Transmitted Case of SARS-CoV-2 Infection in Taiwan. https://www.nejm.org/doi/full/10.1056/NEJMc2001573
Serial interval of novel coronavirus (2019-nCoV) infections
To better understand transmission dynamics, researchers attempted to quantify the serial interval for 2019-nCoV – the time from illness onset in a primary case to illness onset in the secondary case. They compiled a dataset of 30 known pairs of infector-infectee and estimated an average of 2.6 days which is substantially less than for SARS…
February 12, 2020
Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva
A case series of 67 2019-nCoV pneumonia patients (NCP) was evaluated to assess possible 2019-nCoV transmission from aerosol contact with the conjunctiva. A conjunctival swab sample from one patient with no ocular symptoms was RT-PCR positive; one patient with conjunctivitis was RT-PCR negative. [Note: The weak study design did not address their hypothesis, but the…
Diarrhea may be underestimated: a missing link in 2019 novel coronavirus
A gastrointestinal route of infection is proposed by Liang, et al., based on ACE2 [host cell receptor] mRNA expression in healthy human small intestines and other molecular evidence for biologic plausibility. It is hypothesized that eating 2019-nCoV-infected wild animals could result in human infection; and diarrhea as a 2019-nCoV symptom could both indicate a GI…
Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China
A review of all 2019-nCoV patients reported to the Chinese Center for Disease Control and Prevention (Chinese CDC) up to 26 January, 2020 was undertaken to describe the affected populations and to estimate severity and transmissibility. Of 8866 patients, 4021 (45%) were laboratory confirmed. Ages were similar between confirmed and suspect cases (49 years; SD,…
February 11, 2020
Transmission and epidemiological characteristics of Novel Coronavirus (2019-nCoV)-Infected Pneumonia (NCIP):preliminary evidence obtained in comparison with 2003-SARS
Updating a previously-posted pre-print, Zhang, et al. describe their analysis comparing 2019-nCoV pneumonia (NCIP) to 2003-SARS cases to guide prevention and control of the former. Data included public information on Chinese NCIP cases (n=287; age 9-90 years old; male:female ratio, 1.35:1). Compared to SARS, NCIP has a lower case fatality rate and a higher “cure…
The first 2019 novel coronavirus case in Nepal
Bastola, et al. provide a case report of the first confirmed 2019-nCoV case in Nepal. The case was a student in Wuhan returning to Nepal six days after symptom onset on 3 January, 2020. [Note: Potential inconsistency, implies that case left China on 9 Jan (by air) and arrived in Nepal on 13 Jan.] Case…
Transmission of 2019-nCoV infection from an asymptomatic contact in Germany
Rothe, et al. have provided supplementary information regarding their NEJM Correspondence from 31 January, 2020 that reported asymptomatic transmission between a Chinese business traveler and colleagues in Germany. This supplement follows news reports that Bavarian officials found the index case to be potentially symptomatic during her time in Germany. The supplement provides new detail on…
February 10, 2020
Pathogenicity and Transmissibility of 2019-nCoV—A Quick Overview and Comparison with Other Emerging Viruses
Preliminary data suggest that 2019-nCoV may be about 10% less pathogenic than SARS-CoV and about 40% less than MERS-CoV. More research is needed to determine of 2019-nCoV has the same mutation and recombination characteristics found in SARS-CoV or if it is more static like MERS-CoV and to identify key routes of infection, which could be…
The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights
565 Japanese citizens were evacuated from Wuhan at the end of January and were screened for 2019-nCoV symptoms (63 symptomatic) and tested (8 tested positive by RT-PCR, 5 of whom were asymptomatic). Using data from these travelers, researchers estimated the rate of under-ascertainment of cases in Wuhan to be 9.2%. This would suggest a true…
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