Colin Studholme, PhD

Professor

phone: +1 206 221 7022
email: studholm@uw.edu

Bio

C. Studholme, PhDDr. Studholme’s research is focused on mathematical and computational techniques to study brain anatomy and its change over time, with a particular focus on fetal and premature neonatal brain growth. His research group, the Biomedical Image Computing Group, is working on new techniques to solve the problem of how to produce images of the human fetal head in utero—which is especially challenging because the fetal head is often moving. Dr. Studholme's group uses magnetic resonance imaging (MRI) to solve this problem and provide the first high-resolution 3D images of early human brain growth. As part of this project, his group has developed a 4-dimensional computational map of tissue volume changes and surface shape changes that occur when the human brain surface begins to fold, in a process that will go on to form the complex anatomy of the adult human brain. In recent papers, Dr. Studholme’s team has mapped the points at which the first differences in the left and right sides of the brain emerge in the developing fetus. The team has developed techniques to accurately compare brain anatomy in premature babies to that of normally developing fetuses. In addition to his ongoing research in this area, he will be a co-investigator on the randomized controlled trial of Epo neuroprotection in extremely preterm infants (PENUT Trial), with the specific aim of evaluating brain growth of Epo treated infants as compared to controls.

Dr. Studholme is also Professor of Pediatrics and Bioengineering, and Adjunct Professor of Radiology. He completed his Ph.D. in medical physics and biophysics from the University of London and a postdoctoral fellowship in diagnostic radiology at Yale University. He has served as faculty at the University of California-San Francisco, visiting faculty member in biomedical engineering at the Mayo Clinic and at the Fields Institute of the University of Toronto, and has recently become an associate editor for the journal IEEE Transactions on Medical Imaging.

Publications

Peer-Reviewed International Journal Papers

  1. D.L.G. Hill, D.J. Hawkes, T.C.S. Cox, A.J. Strong, W.L. Wong, C.F. Ruff, N. Kitchen, D.G.T. Thomas, J.E. Cross-man, C. Studholme, A.J. Gandhe, S.E.M. Green, G.P. Robinson, “Accurate Frameless Registration of MR and CT Images of the Head: Applications in Surgery and Radiotherapy Planning”, Radiology, 191, 1994, pp 447-454.
  2. A.J. Gandhe, D.L.G. Hill, C. Studholme, D.J. Hawkes, C.F. Ruff, A.J. Strong, T.C.S. Cox, M.J. Gleeson, “Combined and 3D Rendered Multimodal Data for Planning Skull Base Surgery: A Prospective Evaluation”, Neurosurgery, vol 35(3), 1994, pp 463-471.
  3. D.J. Hawkes, C.F. Ruff, D.L.G. Hill, C. Studholme, P.J. Edwards, W.L. Wong, A. Padhani, “3 Dimensional Multi-modal Imaging in Image Guided Interventions”, Seminars in interventional radiology, 12, 1995, pp 63-74.
  4. C. Studholme, D.L.G.Hill, D.J. Hawkes, “Automated 3-D Registration of MR and CT Images of the Head”, Medical Image Analysis, Vol. 1(2), 1996, pp 163-175.
  5. C. Studholme, D.L.G.Hill, D.J. Hawkes, “Automated Three-Dimensional Registration of Magnetic Resonance and Positron Emission Tomography Brain Images by Multiresolution Optimisation of Voxel Similarity Measures”, Medical Physics, Vol. 24(1), Jan 1997, pp 25-35.
  6. J. West, J.M. Fitzpatrick, M.Y. Wang, B.M. Dawant, C.R. Maurer, R.M. Kessler, R.J. Maciunas, C. Barillot, D. Lemoine, A. Collignon, F. Maes, P. Suetens, D. Vandermeulen, P.A. van den Elsen,S. Napel,T.S. Sumanaweera, B. Harkness, P.F. Hemler, D.L.G. Hill, D.J. Hawkes, C. Studholme, J.B.A Maintz, M.A. Viergever, G. Malandain, X. Pennec, M.E. Noz,G.Q. Maguire, M. Pollack, C.A. Pelizzari, R.A. Robb,D. Hanson, R.P. Woods, “Comparison and Evaluation of Retrospective Intermodality Brain Image Registration Techniques”, J Comp. Assist Tomog, Vol 21(4), 1997, pp 554-566.
  7. J. Wong, C. Studholme, D.J. Hawkes, M.N. Maisey, “Evaluation of the Limits of Visual Detection of Image Misregistration in a Brain F18 PET-MRI Study”, European Journal of Nuclear Medicine, Vol 24(6), June 1997, pp 642-650.
  8. D.L.G.Hill, C.R.Maurer, C. Studholme, J.M. Fitzpatrick, D.J.Hawkes, “Correcting Scaling Errors in Tomographic Images Using a Nine Degree of Freedom Registration Algorithm”, J Comput Assist. Tomogr, Vol 22(2), 1998, pp 317-323.
  9. J.M. Fitzpatrick, D.L.G. Hill, Y. Shyr, J. West, C. Studholme, C.R. Maurer, “Visual Assessment of the Accuracy of Retrospective Registration of MR and CT Images of the Brain”, IEEE Trans. Med. Imaging, Vol. 17(4), Aug 1998, pp 571-585.
  10. C. Studholme, D.L.G.Hill, D.J. Hawkes, “An Overlap Invariant Entropy Measure of 3D Medical Image Alignment”, Pattern Recognition, Vol. 32(1), Jan 1999, pp 71-86.
  11. R.A. Avery, S.S. Spencer, C. Studholme, R.Stokking, G. Morano, M. Corsi, J.P. Seibyl, D.D. Spencer, I.G. Zubal, “Reproducibility of Serial Peri-Ictal Single Photon Emission Computed Tomography Difference Images in Epilepsy Patients Undergoing Surgical Resection”, Eur. J Nucl Med, 27(1), 2000, pp 50-53.
  12. R.A. Avery, I.G.Zubal, R. Stokking, C. Studholme, M. Corsi, J.P. Seibyl, S.S. Spencer, “Decreased cerebral blood flow during seizures with ictal SPECT injections”, Epilepsy Research, 2000, 40, pp 53-61.
  13. R.A. Avery, J.S. Francowicz, C. Studholme, C.H. van Dyck, A.F.T. Arnsten, “The Alpha-2A-Adrenoreceptor Agonist, Guanfacine, Increases Regional Cerebral Blood Flow in Dorsolateral Prefrontal Cortex of Monkeys Performing a Spatial Working Memory Task”, Neuropsychopharmacology, 2000, Vol 23, No 3.
  14. P.J. Lewis, A. Siegel, A.M. Siegel, C. Studholme, J. Sojkova,D.W. Roberts,V.M. Thadani, K.L. Gilbert, T.M. Darcey, P.D. Williamson, “Does Performing Image Registration and Subtraction in Ictal Brain SPECT Help Localize Neocortical Seizures”, J Nuc Med, Oct 2000.
  15. I.G. Zubal, R.A. Avery, R. Stokking, C. Studholme, M. Corsi, H. Dey, J.P. Seibyl,S. Spencer, “Ratio-Images Calculated From Interictal Positron Emission Tomography and Single-Photon Emission Computed Tomography for Quantification of the Uncoupling of Brain Metabolism and Perfusion in Epilepsy”, Epilepsia, Vol 41, No. 12, pp 1560-1566, 2000.
  16. C. Studholme, T.C. Constable, J.S. Duncan, “Non-Rigid Spin Echo MRI Registration Incorporating an Image Distortion Model: Application to Accurate Alignment of fMRI to Conventional MRI”, IEEE Trans Med Imaging, Vol 19, No 11. Nov 2000.
  17. J.P. Knisely, J.E. Bond, N.J. Yue, C. Studholme, A.C. de Lotbiniere, “Image Registration and Calculation of a Biologically Effective dose for Multisession Radiosurgical Treatments”, Technical Note: Journal of Neurosurgery, Dec 2000, 93:Suppl 3, pp 208-218.
  18. C. Studholme, E. Novotny, I.G. Zubal, J.S. Duncan, “Estimating Tissue Deformation Between Functional Images Induced by Intracranial Electrode Implantation Using Anatomical MRI”, NeuroImage, Vol 13(4), pp 561-576, 2001.
  19. R.A. Avery, I.G. Zubal, C. Studholme, J. Slawski, M. Corsi, D.D. Spencer, S.S. Spencer, “Interictal 99 Tc-HMPAO SPECT in Temporal Lobe Epilepsy: Relation to Clinical Variables”, Epilepsia, 2001, 42(7), pp 869-874.
  20. Carpentier, K.R. Pugh, M. Westerveld, C. Studholme, O. Skrinjar, J.L. Thompson, D.D. Spencer, R.T. Constable, “Functional MRI of language processing: dependence on input modality and temporal lobe epilepsy”, Epilepsia, pp 1241-1254, Oct, 2001.
  21. D.J. Chang, I.G. Zubal, C. Gottschalk, A. Necochea, R. Stokking, C. Studholme, M. Corsi, J. Slawski, S. S.Spencer, H. Blumenfeld, “Comparison of Statistical Parametric Mapping and SPECT Difference Imaging in Patients with Temporal Lobe Epilepsy”, Epilepsia, 2002.
  22. H. Blumenfeld, M. Westerveld, R.B. Ostroff, S.D. Vanderhill, J. Freeman, A. Necochea, P. Uranga, T. Tanhehco, A. Smoth, J.P. Seibyl, R.Stokking, C. Studholme, S.S. Spencer, I.G. Zubal, “Selective Frontal, Parietal and Temporal Network Activation in Generalized Seizures”, Neuroimage 19:1556-1566 2003.
  23. C. Studholme, V. Cardenas, A. Maudsley, M. Weiner, “An Intensity Consistent Filtering Approach to the Analysis of Deformation Tensor Derived Maps of Brain Shape”, NeuroImage, Vol 19(4), August 2003, pp 1638-1649.
  24. C. Studholme, V. Cardenas, E. Song, F. Ezekiel, A. Maudsley, M. Weiner, “Accurate Template Based Estimation of Brain MRI Bias Fields with Application to Dementia and Aging”, IEEE Transactions on Medical Imaging, Vol 23(1), Jan 2004.
  25. N.J. Yue, J. P.S. Knisely, C. Studholme, Z. Chen, J. Bond, R. Nath, “A Technique to re-establish dose distributions for previously treated brain cancer patients in external beam radiotherapy”, Medical Dosimetry, Vol 29, No. 1, pp 31-41, 2004.
  26. C. Studholme, V. Cardenas, R. Blumenfeld, N. Schuff, H.J. Rosen, B. Miller, M. Weiner, “A Deformation Tensor Morphometry Study of Semantic Dementia with Quantitative Validation”, NeuroImage, Vol 21, pp 1387-1398, April 2004.
  27. D.J. Meyerhoff, R.Blumenfeld, D.Truran, J. Lindgren, D, Flenniken, V.A. Cardenas, L. Chao, J. Rothlind, C. Studholme, M.W. Weiner. “Effects of heavy drinking, binge drinking and family history of alcoholism on regional brain metabolites”, Alcoholism: Clinical and Experimental Research, 28(4), pp 650-661, Apr 2004.
  28. Hal Blumenfeld, Kelly A. McNally, Susan D. Vanderhill, A. LeBron Paige, Richard Chung, Kathryn Davis, Andrew D. Norden, Rik Stokking, Colin Studholme, Edward J. Novotny, Jr., I. George Zubal, and Susan S. Spencer. “Positive and negative network correlations in temporal lobe epilepsy”, Cerebral Cortex, Vol 14(8), 2004, pp 892-902.
  29. C.Studholme, V. Cardenas, “A Template Free Approach to Volumetric Spatial Normalisation of Brain Anatomy”, Pattern Recognition Letters, Vol 25(10), Jul 2004, pp. 1191-1202.
  30. V. Cardenas, L.Chow, R. Blumenfeld, E. Song, D. Meyerhoff, M. Weiner, C. Studholme, “Using Automated Morphometry to Detect Associations between ERP latency and structural brain MRI in normal adults”, Human Brain Mapping, 25, 2005, pp 317-327.
  31. V.A. Cardenas, E. Song, C. Studholme, R. Blumenfeld, D. Truran, D.J. Meyerhoff, M.W. Weiner. “Chronic Active Heavy drinking and family history of problem drinking modulate regional brain tissue volumes”, Psychiatry Research: Neuroimaging, Vol 138, pp 115-130, 2005.
  32. C. Drapaca, V. Cardenas, C. Studholme, “Segmentation of Tissue Boundary Evolution from Brain MR Image Sequences using Multi-phase Level Sets”, Computer Vision and Image Understanding, Vol 100, 2005, pages 312-329.
  33. S. Gazdzinski, T.C. Durazzo, C. Studholme, E. Song, P. Banys, D.J. Meyerhoff, “Quantitative brain MRI in alcohol dependence: preliminary evidence for effects of concurrent chronic cigarette smoking on regional brain volumes”, Alcohol Clin Exp Res, 2005 Aug; 29(8):1484-95.
  34. Colin Studholme, Corina Drapaca, Bistra Iordanova, Valerie Cardenas, “Deformation Based Mapping of Volume Change from Serial Brain MRI in the Presence of Local Tissue Contrast Change”, IEEE Transactions on Medical Imaging, Vol 25(5), pp 626-639, May 2006.
  35. Bistra Iordanova, Daniel Rosenbaum, David Norman, Michael Weiner, Colin Studholme, “MRI study of Neurodegeneration: A Robust Volumetric Parcellation Method of the Frontal Lobe Gyri with Quantitative Validation in Dementia Patients”, AJNR, Vol 27, pp 1747-1754, Sep 2006.
  36. Maudsley, A. Darkazanli, J.R. Alger, L.O. Hall, N. Schuff, C. Studholme, Y. Yu, A. Ebel, A. Frew, D. Goldgof, Y.Gu, R. Pagare, F. Rousseau, K. Sivasankaren, B.J. Soher, P. Weber, K. Young, X. Zhu, “Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging”, NMR in Biomedicine, June 2006, 19(4), pp 492-503.
  37. A.D. Leow, A.D. Klunder, C.R. Jack, A.W. Toga, A.M. Dale, M.A. Bertstein, P.J. Britson, J.L. Gunter, C.P. Ward, J.L. Whitewell, B. Borowski, A. Fleisher, N.C. Fox, D. Harvery, J. Kornak, N. Schuff, C. Studholme, G.E. Alexander, M.W. Weiner, P.M. Thompson, “Longitudinal Stability of MRI for Mapping Brain Change using Tensor-Based Morphometry”, Neuroimage, June 2006, 31(2) pp 627-640.
  38. F. Rousseau, O. Glenn, B. Iordanova, Cl. Rodriguez, D. Vigneron, J. Barkovich, C. Studholme, “Registration Based Approach for Reconstruction of High Resolution In Utero MR Brain Images”, Academic Radiology, 13(9), Sept 2006, pp 1072-1081.
  39. T. Durazzo, V.A. Cardenas, C. Studholme, M.W. Weiner, D.J. Meyerhoff, “Non-treatment-seeking heavy drinkers: Effects of chronic smoking on brain structure”, Drug Alcohol Depend, 87, Jan 2007, pp 76-82.
  40. V.A. Cardenas A.L. Boxer, L.L.Chao, M.L. Gorono-Tempini, B.L. Miller, M.Weiner, C. Studholme, “Deformation Morphometry Reveals Brain Atrophy in Frontotemporal Dementia”, Archives of Neurology, 64(6), pp 873-877, June 2007.
  41. V. Cardenas, C. Studholme, S. Gazdzinski, T. Durazzo D. Meyerhoff, “Deformation Based Morphometry of Brain Volume Changes During Recovery from Alcohol Dependence”', Neuroimage, Vol 34(3), 2007, pp 879-887.
  42. Durazzo TC, Rothlind JC, Cardenas VA, Studholme C, Weiner MW, Meyerhoff DJ., “Chronic cigarette smoking and heavy drinking in human immunodeficiency virus: consequences for neurocognition and brain morphology”, Alcohol, 2007 Nov, 41(7):489-501. Epub 2007 Oct 17.
  43. K. Strostrand, E. Rostrup, C. Ryberg, R. Larsen, C. Studholme, H. Baezner, J. Ferro, F. Fazekas, L. Pantoni, D. Inzitari, and G. Waldemar “Sparse Decomposition and Modeling of Anatomical Shape Variation”, IEEE Transactions on Medical Imaging, Vol 26(12), Dec 2007, pp 1625-1635.
  44. C. Rodriguez, Pratik Muhkerjee, D. Vigneron, J. Barkovich, C. Studholme, “A Framework for in-vivo analysis of regional brain folding in premature neonates”, NeuroImage, Vol. 41, no. 2, pp. 462-478, 2008.
  45. Norbert Schuff , Thomas C. Neylan, Sabrina Fox-Bosetti, Maryanne Lenoci, Kristin W. Samuelson, C. Studholme, John Kornak, Charles R. Marmar, Michael Weiner, “Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder”, Psychiatry Research Neuroimaging, 2008.
  46. Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, Weiner MW. “The Alzheimer’s Disease Neuroimaging Initiative (ADNI): MRI methods”, J Magn Reson Imaging, 2008 Apr; 27(4):685-91.
  47. J Blumenfeld, C Studholme, J Carballido-Gamio, D Carpenter, T M. Link, S Majumdar, “Three-dimensional image registration of MR proximal femur images for the analysis of trabecular bone parameters”, Med Phys, Vol. 35, no. 10, pp. 4630-4639, October 2008.
  48. C. Studholme, “Dense Feature Deformation Morphometry: Incorporating DTI Data into Conventional MRI Morphometry”, Medical Image Analysis, Vol 12, Issue 6, December 2008, pp 742-751 2008.
  49. S. Hadjidemetriou, C. Studholme, S. Mueller, M. W. Weiner, N. Schuff, "Restoration of MRI data for intensity non-uniformities using local high order intensity statistics," Med Image Anal, Vol. 13, no. 1, pp. 36-48, February 2009.
  50. A. Maudsley, C. Domenig, V. Govindaraju, A. Darkazanli, C. Studholme, K. Arheart, and C. Bloomer. “Mapping of brain metabolite distributions by volumetric proton MRSI”, Magn Reson Med, Vol. 61, no. 3, pp 548-559, March 2009.
  51. Valerie Cardenas, Linda L Chao, Colin Studholme, Kristine Yaffe, Bruce L Miller, Catherine Madison, Shannon Buckley, Dan Mungas, Norbert Schuff, Michael W Weiner,”Brain atrophy associated with baseline and longitudinal measures of cognition”, Neurobiology of Aging, Vol 32, no. 4, pp 572-580, April 2011.
  52. V.A. Cardenas, D.J. Meyerhoff, C. Studholme, J. Kornak, J. Rothlind, H. Lampiris, J. Neuhaus, R.M. Grant, M.D, L.L. Chao, D. Truran, B.A., and M.W. Weiner,M.D. “Evidence for Ongoing brain injury in HIV+ patients treated with antiretroviral therapy”, Journal of Neurovirology, Vol 15, no 4, pp 324-333, June 2009.
  53. N. Schuff, S. Matsumoto, J. Kmiecik, C. Studholme, A.T.Du, F. Ezekiel,B.L. Miller, J.H. Kramer, W.J. Jagust, H.C. Chui, M.W.Weiner. “Cerebral Blood Flow in Ischemic Vascular Dementia and Alzheimer's Disease By Arterial Spin Labeling MRI”, Alzheimer's&Dementia, Vol 5, Issue 6, pp 454-462, Nov 2009.
  54. Schneider MM, Berman JI, Baumer FM, Glass HC, Jeng S, Jeremy RJ, Esch M, Biran V, Barkovich AJ, Studholme C, Xu D, and Glenn OA. “Normative ADC values in the developing fetal brain”, American Journal of Neuroradiology, Oct 2009.
  55. K.Young, V. Govindaraju, K. Sharma, C. Studholme, A.A Maudsley, N. Schuff, “Multivariate Statistical Mapping of Spectroscopic Imaging Data ”, Magn Reson Med, Vol 63, no 1, pp 20-24, January 2010.
  56. K.Kio, P. Habas, O. Glenn, A.J. Barkovich, C. Studholme, “Intersection Based Motion Correction of Multi-Slice MRI for 3D in utero Fetal Brain Image Formation”, IEEE Trans Med Imaging, Vol 29, no 1, pp 146-158, January 2010.
  57. P. A. Habas, K. Kim, F. Rousseau, O. A. Glenn, A. J. Barkovich, C. Studholme, "Atlas-based segmentation of developing tissues in the human brain with quantitative validation in young fetuses," Hum Brain Mapping, 31: 1348-1358.
  58. P. A. Habas, K. Kim, J. M. Corbett-Detig, F. Rousseau, O. A. Glenn, A. J. Barkovich, and C. Studholme, A spatiotemporal atlas of MR intensity, tissue probability and shape of the fetal brain with application to segmentation," Neuroimage, 53 (2), pp 460–470.
  59. E. W.Y. Tam, S. P. Miller, C. Studholme, V. Chau, D. Glidden, K. J. Poskitt, D. M. Ferriero, A. James Barkovich, “Differential Effects of Intraventricular Hemorrhage and White Matter Injury on Preterm Cerebellar Growth”, J Pediatr, Vol 158, no 3, pp 366-371, March 2011.
  60. J. M. Corbett-Detig, P. A. Habas, J. A. Scott, K. Kim, V. Rajagopalan, P. S. McQuillen, A. J. Barkovich, O. A. Glenn, C. Studholme, “3D global and regional patterns of human fetal subplate growth determined in utero”, Brain Struct Funct, Vol 215, no 3-4, pp 255-263, January 2011.
  61. V. Rajagopalan, J. A. Scott, P. A. Habas, J. M. Corbett-Detig, K. Kim, F. Rousseau, A. J. Barkovich, O. A. Glenn, C. Studholme, “Local tissue growth patterns underlying normal fetal human brain gyrification quantified in utero”, J Neurosci, Vol 31, no 8, pp 2878-2887, February 2011.
  62. F. D. Jacob, P. A. Habas, K. Kim, J. M. Corbett-Detig, D. Xu, C. Studholme, O. A. Glenn, "Fetal hippocampal development: analysis by magnetic resonance imaging volumetry," Pediatr Res, Vol 69, no 5, pp 425-429, May 2011.
  63. J. A. Scott, P. A. Habas, K. Kim, V. Rajagopalan, K. S. Hamzelou, J. M. Corbett-Detig, A. J. Barkovich, O. A. Glenn, C. Studholme, "Growth trajectories of the human fetal brain tissues estimated from 3D reconstructed in utero MRI," Int J Dev Neurosci, Vol 29, no 5, pp 529-536, August 2011.
  64. C. Studholme, "Mapping fetal brain development in utero using MRI: the big bang of brain mapping," Annual Rev. Biomed Eng, Vol 13, no 1, pp 345-368, August 2011.
  65. B. Caldairou, N. Passat, P. A. Habas, C. Studholme, F. Rousseau, "A non-local fuzzy segmentation method: application to brain MRI," Pattern Recognit, Vol 44, no 9, pp 1916-1927, September 2011.
  66. Valerie A. Cardenas, Timothy C. Durazzo, Stefan Gazdzinski, Anderson Mon, Colin Studholme, Dieter J. Meyerhoff, “Brain Morphology at Entry into Treatment for Alcohol Dependence Is Related to Relapse Propensity”, Biological Psychiatry, Vol 70, pp 561–567, September 2011.
  67. Tam EW, Chau V, Ferriero DM, Barkovich AJ, Poskitt KJ, Studholme C, Fok ED, Grunau RE, Glidden DV, Miller SP. “Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids”, Science Translational Medicine 3 (105), 2011.
  68. Michael W Weiner, Dieter J Meyerhoff, Thomas C Neylan, Jennifer Hlavin, Erin R Ramage, Daniel McCoy, Colin Studholme, Valerie Cardenas, Charles Marmar, Diana Truran, Philip W Chu, John Kornak, Clement E Furlong, Charles McCarthy, “The relationship between gulf war illness, brain N-acetyl aspartate and post-traumatic stress disorder”, Military Medicine, Vol 176(8), pp 896-902, 2011.
  69. J.I. Berman, S.E.G. Hamrick, P.S. McQuillen, C. Studholme, D. Xu, R.G. Henry, L.K. Hornbergerd, O.A. Glenn, “Diffusion-Weighted Imaging in Fetuses with Severe Congenital Heart Defects”, American Journal of Neuroradiology, Vol 32, pp 21-22, 2011.
  70. Valerie A Cardenas, Kristin Samuelson, Maryann Lenoci, Colin Studholme, Thomas C Neylan, Charles R Marmar, Norbert Schuff, Michael W Weiner, "Changes in brain anatomy during the course of posttraumatic stress disorder", Psychiatry Research: Neuroimaging, Vol 193(2), pp 93-100, 2011.
  71. K. Kim, P. A. Habas, V. Rajagopalan, J. A. Scott, J. M. Corbett-Detig, F. Rousseau , A. J. Barkovich, O A. Glenn, C. Studholme, "Bias field inconsistency correction of motion-scattered multislice MRI for improved 3D image reconstruction,” IEEE Trans Med Imaging, 30 (9), pp 1704-1712, 2011.
  72. O.A. Glenn,E.M. Quiroz, J.I. Berman,C. Studholme, D. Xu, “Diffusion-Weighted Imaging in Fetuses with Unilateral Cortical Malformations and Callosal Agenesis”, American Journal of Neuroradiology, 31, pp 1100-1102, 2011.
  73. F. Rousseau, P. A. Habas, C. Studholme, "A supervised patch-based approach for human brain labeling," IEEE Trans Med Imaging, Vol 30, no 10, pp 1852-1862, October 2011.
  74. P. A. Habas, J. A. Scott, A. Roosta, V. Rajagopalan, K. Kim, F. Rousseau, A. J. Barkovich, O. A. Glenn, C. Studholme, "Early folding patterns and asymmetries of the normal human brain detected from in utero MRI”, Cereb Cortex, Jan; 22(1):13-25, 2012.
  75. E. Oubel, M. Koob, C. Studholme, J.-L. Dietemann, F. Rousseau, "Reconstruction of scattered data in fetal diffusion MRI”, Med Image Anal, Vol. 16, no 1, pp 28-37, January 2012.
  76. J. A. Scott, K. S. Hamzelou, V. Rajagopalan, P. A. Habas, K. Kim, A. J. Barkovich, O. A. Glenn, C. Studholme, "3D morphometric analysis of human fetal cerebellar development”, Cerebellum, 11(3):761-70, Sep 2012
  77. V. Rajagopalan, J. Scott, P.A. Habas, K. Kim, F. Rousseau, A.J. Barkovich, O.A. Glenn, C. Studholme, "Mapping directionality specific volume changes using tensor based morphometry: An application to the study of gryrogenesis and lateralization of the human fetal brain”, NeuroImage, 1;63(2):947-58, Nov 2012.
  78. J. Scott, V. Rajagopalan, P.A. Habas, K. Kim, A.J. Barkovich, O.A. Glenn, C. Studholme, "Volumetric and surface-based 3D MRI analyses of fetal isolated mild ventriculomegaly”, Brain Struct Funct, 2012.
  79. François Rousseau, Estanislao Oubel, Julien Pontabry, Marc Schweitzer, Colin Studholme, Mériam Koob, Jean-Louis Dietemann, “BTK: An open-source toolkit for fetal brain MR image processing”, Comput Methods Programs Biomed, 109(1):65-73, Jan 2013.
  80. Atman Desai, Kimon Bekelis, Vijay M. Thadani, David W. Roberts1, Barbara C. Jobst, Ann-Christine Duhaime, Karen Gilbert, Terrance M. Darcey, Colin Studholme, Alan Siegel, “Interictal PET and ictal subtraction SPECT: Sensitivity in the detection of seizure foci in patients with medically intractable epilepsy”, Epilepsia, 54(2):341-50, Feb 2013.
  81. Moriah E. Thomason, Maya T. Dassanayake, Stephen Shen, Yashwanth Katkuri, Mitchell Alexis, Amy L. Anderson Lami Yeo, Swati Mody, Edgar Hernandez-Andrade Sonia S. Hassan, Colin Studholme, Jeong-Won Jeong, Roberto Romero, “Cross-Hemispheric Functional Connectivity in the Human Fetal Brain”, Sci Transl Med 5, 173, 2013
  82. J. Pontabry, F. Rousseau , E. Oubel, C. Studholme, M. Koob, J.-L. Dietemann,Probabilistic, “Tractography Using Q-Ball Imaging and Particle Filtering: Application to Adult and in-utero Fetal Brain Studies”, Medical Image Analysis, Vol 17, Issue 3, pp 297–310, April 2013.
  83. C. Studholme, F. Rousseau, “Quantifying and modelling tissue maturation in the living human fetal brain”, International Journal of Developmental Neuroscience, In Press, 2013.