SLIMMER The Slice MRI Motion Estimation and Reconstruction (SLIMMER) tool is intended to allow the formation of a single 3D high resolution image from multiple sets of lower resolution multi-slice MRI data, where regional tissue motion can occur between the acquisition of slices. The input data is a set of raw DICOM format multi-slice data. The final output is a single volume image in GIPL or NIFTI format. The plugin tool for rview provides a graphical user interface to load data, automatically initialize the stack alignment from scanner coordinates, select the region of interest and then to inspect the result of regional between-slice motion estimation, bias inconsistency correction and volume reconstruction algorithms.