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Synthesis and optimization of nanoparticle contrast agents for MRI
Funding: NIH/NINDS

Project Summary:
Contrast agents play an important role in improving the diagnostic capability of Magnetic Resonance Imaging (MRI). In general, paramagnetic ions such as Mn or Gd are used to provide contrast in T1-weighted images, while superparamagnetic nanoparticles are utilized in T2-weighted imaging. We are trying to develop a new T1 contrast agent composed of MnO nanoparticles. The advantages of nanoparticle-based Mn contrast agents include pH-dependent properties, allowing contrast to be delivered selectively depending on the local environment, and easy access to linking with biomolecules. Several known surface modifications enable us to link our nanoparticles with specific molecules to form molecular probes that can be used as in vivo diagnostic tools.

In collaboration with Dr. Alan Koretsky and Mr. Jason Tucciarone of NIH/NINDS, we are studying how our particles are transported in rat brains.

 

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