Choi M., Genereux D.P., Goodson J., Al-Azzawi H., Allain S.Q., Simon N., Palasek S., Ware C.B., Cavanaugh C., Miller D.G., Johnson W.C., Sinclair K.D., Stöger R., Laird C.D. (2017) Epigenetic Memory via Concordant DNA Methylation is Inversely Correlated to Developmental Potential of Mammalian Cells. PLoS Genet. 13(11):e1007060 .pdf
Genereux D.P. and Laird, C.D.(2013) At what rate do new premutation alleles arise at the fragile X locus? Human Genetics 132(6):715-7 .pdf
Genereux D.P. and Laird C.D. (2013). Why do fragile X carrier frequencies differ between Asian and non-Asian populations? Genes Genet. Syst. 88: 211-224 .pdf
Fu A.Q., Genereux D.P., Stoger, R., Burden, A.F. Laird, C.D. and Stephens, M. (2012) Statistical Inference of In Vivo Properties of Human DNA Methyltransferases from Double-Stranded Methylation Patterns. PLoS One 7(3):e32225 .pdf
Smith R., Brownfield M., Harlan T., Shepherd J.H., Laird C.D. and Genereux D.P. (2012) Landscape Restoration and Stewardship Funded in Perpetuity through Home-site and Golf Course Development. J of Sustainable Real Estate 4(1):198-211
Stöger R., Genereux D.P., Hagerman R.J., Hagerman P.J., Tassone F., and Laird C.D. (2010) Testing the FMR1 promoter for mosaicism in DNA methylation among CpG sites, strands, and cells in FMR1-expressing males with fragile X syndrome. PLoS One 6(8): e23648. .pdf
Fu, A., Genereux, D.P., Stöger, R., Laird, C.D., and Stephens, M. (2010) Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals. Ann. Appl. Stat. 4: 871-892. .pdf
2009
Genereux, D.P. (2009). Asymmetric Strand Segregation: Epigenetic Costs of Genetic Fidelity? PLoS Genet 5(6): e1000509. doi:10.1371/journal.pgen.1000509..pdf
2008
Stöger, Reinhard (2008). The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? Bioessays 30: 156-166. .pdf
Wirojanan, J., Kraff, J., Hawkins, D., Laird, C., Gane, L., Angkustsiri, K., Tassone, F., and Hagerman, R. (2008). Two Boys With Fragile X Syndrome and Hepatic Tumors. J. Ped. Hematology/Oncology 30: 239-241.
Genereux, D.P., Johnson, W.C., Burden, A.F., Stöger, R., and Laird, C.D. (2008). Errors in the Bisulfite Conversion of DNA: Modulating Inappropriate- and Failed-Conversion Frequencies. Nucl. Acids Res. 1-19. doi:10.1093/nar/gkn691 .pdf
2007
McCloskey, M.L., Stöger, R., Hansen, R.S., and Laird, C.D. (2007). Encoding PCR Products with Batch-stamps and Barcodes. Biochemical Genetics 45: 761-767. .pdf
2006
Stöger, Reinhard (2006). In Vivo Methylation Patterns of the Leptin Promoter in Human and Mouse. Epigenetics 1: 155-162. .pdf
2005
Genereux, D.P., Miner, B.E., Bergstrom, C.T., and Laird, C.D. (2005). A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns. Proc. Natl. Acad. Sci. USA. .pdf
Burden, A.F., Manley, N.C., Clark, A.D., Gartler, S.M., Laird, C.D., and Hansen, R.S. (2005). Hemimethylation and non-CpG methylation levels in a promoter region of human LINE-1 (L1) repeated elements. J. Biological Chemistry 280: 14413-14419. .pdf
Fetal fibroblast L1 sequences used in Burden et al., 2005
Other L1 sequences used for Table I in Burden et al., 2005
Revised Table I for Burden et al., 2005
2004
Miner, B.E., Stöger, R.J., Burden, A.F., Laird, C.D., and Hansen, R.S. (2004). Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR . Nucl. Acids Res. 32 , e135. .pdf
Laird, C.D., Pleasant, N.D., Clark, A.D., Sneeden, J.L., Hassan, K.M. A, Manley, N.C., Vary, J.C.Jr., Morgan, R., Hansen, R.S., and Stöger, R. (2004) Hairpin-bisulfite PCR: Assessing Epigenetic Methylation Patterns on Complementary Strands of Individual DNA Molecules. Proc. Natl. Acad. Sci. USA 101, 204-209. .pdf
2002
Hansen, R.S., and Laird, C.D. (2002). A new regulatory pathway for fragile X syndrome? Nature Medicine 8, 1204-1205. .pdf
2000
Hansen, R.S., Stoeger, R., Wijmenga, C., Vary, J.C., Stanek, A.M., Canfield, T.K., Luo, P., Matarazzo, M.R., D'Esposito, M., Feil, R., Gimelli, G., Weemaes, C.M.R., Laird, C.D., and Gartler, S.M. (2000). Escape from gene silencing in ICF syndrome and evidence for advanced replication time as a major determinant. Hum. Molec. Genetics 9: 2575-2587. .pdf
Widrow, R.J., and Laird, C.D. (2000). Enrichment for submitotic cell populations using flow cytometry. Cytometry 39: 126-130. .pdf
1998
Widrow, R.J., Hansen, R.S., Kawame, H., Gartler, S.M., and Laird, C.D. (1998). Very late DNA replication in the human cell cycle. Proc. Natl. Acad. Sci. USA 95: 11246-11250. .pdf
Tapscott, S.J., Klesert, T.R., Widrow, R.J., Stöger, R., and Laird, C.D. (1998). Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes. Current Opinion in Genetics and Development 8: 245-253.
Laird, C. (1998). Rules of DNA methylation in humans inferred from the fragile X gene, FMR1. in Epigenetics (CIBA/Novartis Foundation Symposium 214), pp 280-290, edited by D. H. Chadwick and G. Cardew. Wiley and Sons, Chichester.
1997
Hirst, M.C., Arinami, T., and Laird, C.D. (1997). Sequence analysis of long Japanese FMR1 arrays: insights into the generation of long (CGG) n tracts. Human Genetics 101: 214-218. .pdf
Stöger, R., Kajimura, T.M., Brown, W.T., and Laird, C.D. (1997). Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene, FMR1. Hum Molec Gentics 6: 1791-1801. .pdf
Hansen, R.S., Canfield, T.K., Fjeld, A.D., Mumm, S., Laird, C.D., and Gartler, S.M. (1997). A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication. Proceedings of the National Academy of Science 94: 4587-4592. .pdf
Widrow, R.J., Rabinovitch, P.S., Cho, K., and Laird, C.D. (1997). Separation of cells at different times within G2 and mitosis by cyclin B1 flow cytometry. Cytometry 26: 1-5. .pdf
1996
Ji, J, Clegg, N.J.M., Peterson, K., Jackson, A.L., Laird, C.D., and Loeb, L.A. (1996). In vitro expansion of GGC:GCC repeats: identification of the preferred strand of expansion. Nucl. Acids. Res. 24: 2835-2840. .pdf
1993
Laird, C.D., Hansen, R.S., Canfield, T.K., Lamb, M.M., and Gartler, S.M. (1993). Chromosomal fragile sites: molecular test of the delayed-replication model. Cold Spring Harbor Symposium Quantitative Biology, Volume LVIII, pp 633-635. .pdf
Laird, C.D. (1993). Imprinting and Imprint Erasure as viewed through the fragile-X syndrome. Am. J. Med. Genet. 46: 687-688.
Hansen, R.S., Canfield, T.K., Lamb, M.M., Gartler, S.M., and Laird, C.D. (1993). Association of fragile-X syndrome with delayed replication of the FMR1 gene. Cell 73 : 1403-1409. .pdf
1992
Hansen, R.S., Gartler, S.M., Scott, C.R., Chen, S.H., and Laird, C.D. (1992). Methylation analysis of CGG sites in the CpG island of the human FMR1 gene. Hum Molec Genetics 1: 571-578. .pdf
Laird, C.D. (1992). The plural of heterochromatin. pp 155-172, in "Dynamic Genome," N. Fedoroff and D. Botstein, eds. Cold Spring Harbor Laboratory Press, New York.
Sabl, J. F., and Laird, C. D. (1992). Epigene Conversion: a proposal with implications for gene mapping in humans. Am J Hum Genet 50: 1171-1177.
Follette, P. and Laird, C. (1992). Estimating the stability of the proposed imprinted state of the fragile-X mutation when transmitted by females. Hum Genet 88: 335-343.
1991
Nelson, R., Odell, G., Christiansen, A., and Laird, C. (1991). Hormonal control of gene expression: Interactions between two trans-acting regulators in Drosophila. Developmental Biology 144: 152-166.
Laird, C. D. (1991) The X-inactivation imprinting model of the fragile-X syndrome: annotated references 1990 . In: "Fragile X and Cancer Genetics" pages 101-110 (Progress in Clinical and Biological Research, volume 368, Birth Defects Symposium XX), A. M. Willey and P. D. Murphy, editors. Alan R. Lis, Inc., New York. (review)
Laird, C. D., Lamb, M.M., Sved, J., and Thorne, J. (1991). Modeling the inheritance and expression of the fragile-X syndrome, with emphasis on the X-inactivation imprinting model . pp 228-251, In: "Fragile-X syndrome: diagnosis, treatment, and research," R. Hagerman and A. Cronister Silverman, editors. The Johns Hopkins University Press. (review)
Laird, C. (1991). Possible erasure of the imprint on a fragile-X chromosome when transmitted by a male. Am J Med Genet 38: 391-395.
1990
Laird, C., Sved, J., Thorne, J., and Lamb, M. (1990). The X-inactivation imprinting model of the fragile-X syndrome: annotated references, 1989 . in "Chromosomes Today," volume 10, pages 163-165 (Karl Fredga, editor; Unwin Hyman Limited, London. (review)
Laird, C., Lamb, M., and Thorne, J. (1990). Two progenitor cells for human oogonia inferred from pedigree data and the X-inactivation imprinting model of the fragile-X syndrome. Am J Human Genetics 46: 696-719. .pdf
Sved, J. A., and Laird, C. (1990). Population genetic consequences of the fragile-X syndrome based on the X-inactivation imprinting model . Am J Human Genetics 46: 443-451. .pdf
Laird, C. (1990). Proposed genetic basis of Huntington's disease. Trends in Genetics 6: 242-247.
1989
Laird, C. D. (1989). From polytene chromosomes to human embryology: connections via the human fragile-X syndrome of mental retardation. Amer. Zool. 29: 569-593. (review)
Champe, M., and Laird, C. (1989). Nucleotide sequence of a cDNA from the putative ovarian tumor locus of Drosophila melanogaster. Nucleic Acids Research 17: 3304. .pdf
1988
Sved, J. A., and Laird, C.D. (1988). The X-inactivation imprinting model can explain the incidence of the fragile-X syndrome of mental retardation in mother-offspring pairs. Brain Dysfunction 1: 245-254.
Laird, C., and Lamb, M. (1988). Intercalary heterochromatin of Drosophila as a potential model for human fragile sites. American Journal of Medical Genetics 30: 689-691. (review)
Laird, C. (1988). Fragile-X mutation proposed to block complete reactivation in females of an inactive X chromosome. American Journal of Medical Genetics 30: 693-696. (review)
Karpen, G., Schaefer, J., and Laird, C. (1988). Function of a Drosophila rDNA gene located in euchromatin. Genes and Development 2: 1745-1763. .pdf
1987
Lamb, M., and Laird, C. (1987). Three euchromatic DNA sequences under-replicated in polytene chromosomes of Drosophila are localized in constrictions and ectopic fibers. Chromosoma 95: 227-235. .pdf
Laird, C., Jaffe, E., Karpen, G., Lamb, M., and Nelson, R. (1987). Fragile sites in human chromosomes as regions of late-replicating DNA. Trends in Genetics 3: 274-281. .pdf
Laird, C. (1987). Proposed mechanism of inheritance and expression of the fragile-X syndrome of mental retardation. Genetics 117: 587-599. .pdf
1986
Laird, C., Hammond, M., and Lamb, M. (1986). Polytene chromosomes of Drosophila. In "Chromosomes Today", Vol. IX, edited by A. Stahl (George, Allen, and Unwin, Hemel Hempstead, England, C. 1987. (review)
Jaffe, E., and Laird, C. (1986). Dosage Compensation in Drosophila. Trends in Genetics 2: 316-321. (review)
1985
Hammond, M. P., and Laird, C. (1985). Chromosome structure and DNA replication in nurse and follicle cells of Drosophila melanogaster. Chromosoma 91: 267-278.
Hammond, M. P. and Laird, C. (1985). The control of DNA replication and the spatial distribution of defined DNA sequences in salivary gland cells of Drosophila melanogaster. Chromosoma 91: 279-286.
1983
Chooi, W. Y., and Laird, C. (1983). Morphological Analyses of Active Genes and Chromatin. J. American Medical Association 250: 82-83. (photoessay)
1982
Brock, H. W., and Laird, C. (1982). Molecular tests of Polytene Chromosome Models Derived from Cytological Observations. In Proceedings of Saporo Conference The Ultrastructure and Functioning of Insect Cells, pp. 21-24. edited by H. Akai, et al., Soc. for Insect Cells Japan. (review)
Foe, V., Forrest, H., Wilkinson, L., and Laird, C. (1982). Morphological Analysis of transcription in insect embryos. In Insect Ultrastructure, Vol. 1, 222-26, edited by H. Akai and R. King (Plenum Publ. Corp., N.Y., c. 1982). (review)
1981
Laird, C., Wilkinson, L., Johnson, D., and Sandstrom, C. (1981). Proposed Structural Principles of Polytene Chromosomes. In "Chromosomes Today", vol. VII, edited by M. Bennett, M. Bobrow, and G. Hewitt (George, Allen, and Unwin, Hemel Hempstead, England, c. 1981). (review)
1980
Laird, C. D. (1980). Structural paradox of polytene chromosomes. Cell 22: 869-874.
Laird, C. D., Ashburner, M., and Wilkinson, L. (1980). Relationship between relative dry mass and average band width in regions of polytene chromosomes of Drosophila. Chromosoma 76: 175-189.
1976
Laird, C. D., and W. Y. Chooi (1976). Morphology of transcription units in Drosophila melanogaster. Chromosoma 58: 169-194.
Foe, V. E., Wilkinson, L. E., and Laird, C. D. (1976). Comparative organization of active transcription units in Oncopeltus fasciatus. Cell 9: 131-146.
Laird, C. D., Wilkinson, L. E., Foe, V. E., and Chooi, W. Y. (1976). Analysis of chromatin-associated fiber arrays . Chromosoma 58: 195-218.
Lamb, M. M., and C. D. Laird (1976). The size of poly-A-containing RNAs in Drosophila melanogaster embryos. Biochemical Genetics 14: 357-371.
Lamb, M. M., and Laird, C. D. (1976). Increase in nuclear poly A-containing RNA at syncytial blastoderm in Drosophila melanogaster embryos. Develop. Biol. 52: 31-42.
Chooi, W. Y., and Laird, C. D. (1976). DNA and polyribosome-like structures in lysates of mitochondria of Drosophila melanogaster. J. Molec. Biol. 100: 493-518.
1974
Laird, C. D. (1974). DNA of Drosophila chromosomes. Annual Reviews of Genetics 7: 177-204. (review)
1973
Turner, S. H., and Laird, C. D. (1973). Diversity of RNA sequences in Drosophila melanogaster. Biochemical Genetics 10: 263-274.
Laird, C. D., Chooi, W. Y., Cohen, E., Dickson, E., Hutchinson, N., Turner, S. (1973). Organization of Drosophila DNA. Cold Spring Harbor Symposium on Quantitative Biology 38:311-327. (review)
Bultmann, H., and Laird, C. D. (1973). Mitochondrial DNA of Drosophila melanogaster. Biochim. et Biophys. Acta. 299: 197-206.
Lagowski, J., Yu, M-Y., Forrest, H. S., and Laird, C. D. (1973). Dispersity of repeat DNA sequences in Oncopeltus fasciatus, an organism with diffuse centromeres. Chromosoma 43: 349-373.
1971
Dickson, E., J. Boyd, and C. D. Laird (1971). Sequence diversity of polytene chromosome DNA from Drosophila hydei. J. Molec. Biol. 61: 615-627.
Hahn, W., and C. D. Laird (1971). Transcription of non-repeated DNA in mouse brain. Science 173: 158-161.
Lambert, C., and C. D. Laird (1971). Molecular properties of tunicate DNA. Biochim. Biophys. Acta 240: 39-47.
Laird, C. D. (1971). Chromatid structure: relationship between DNA content and nucleotide sequence diversity. Chromosoma 32: 378-406.
1969
Laird, C. D., and B. J. McCarthy (1969). Molecular characterization of the Drosophila genome. Genetics 63: 865-882.
McConaughy, B. L., C. D. Laird, and B. J. McCarthy (1969). Nucleic acid reassociation in formamide. Biochemistry 8: 3289-3295.
Laird, C. D., B. McConaughy, and B.J. McCarthy (1969). On the rate of fixation of nucleotide substitutions in evolution. Nature 224: 149-154.
1968
Laird, C. D., L. Wang, and Bodmer, W. F. (1968). Recombination and DNA replication in B. subtilis transformation. Mutation Research 6: 205-209.
Laird, C. D., and McCarthy, B. J. (1968). Nucleotide sequence homology within the genome of Drosophila melanogaster. Genetics 60: 323-334.
Laird, C. D., and McCarthy, B. J. (1968). Magnitude of interspecific nucleotide sequence variability in Drosophila. Genetics 60: 303-322.
Bodmer, W. F., and Laird, C. D. (1968). Molecular mechanism of recombination in B. subtilis transformation. Replication and recombination of genetic material. pp. 184-205. Edited by Peacock and Brock. Australian Academy of Science. (review)
1967
Laird, C., and Bodmer, W. (1967). Utilization of 5-bromouracil by Bacillus subtilis. J. Bacteriol. 94: 1277-1278.
1962
Novitski, E., Cohen, J., and Laird, C. (1962). Hohe Mosaikfrequenz als Folge von Chromosomenbrucken bei Drosophila melanogaster. Archiv der Julius Klaus- stiftung Band XXXVII, Heft 3/4: 27.
1961
Stahl, F. W., Crasemann, J., Okun, L., Fox, E., and Laird, C. (1961). Radiation sensitivity of bacteriophage containing 5-bromodeoxyuridine. Virology 13: 98-104.