Global WACh

Research


August 29, 2024

New study aims to evaluate a novel pediatric TB diagnostic tool and treatment response

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Investigators Dr. Sylva LaCourse (UW), Dr. Tony Hu (Tulane University), and Dr. Vidalis Nduba (KEMRI CRDR)

Young children account for 50% of pediatric tuberculosis (TB) cases but are least likely to be diagnosed and are at the highest risk of death without prompt treatment. Current available diagnostics – typically sputum-based – often fail to identify TB in children and are generally not reliable for measuring treatment response. There is a need to develop and evaluate novel diagnostic tools utilizing blood and urine, which may identify pediatric TB missed by respiratory sampling.

A new five-year study titled “CRISPR-TB for pediatric TB diagnosis and treatment response” funded by the National Institutes of Health will support an evaluation of a CRISPR-based technology to target and detect Mycobacterium tuberculosis cell-free DNA (cfDNA). The study’s findings may provide a deeper understanding of its potential to diagnosis pediatric TB early and accurately and improve treatment responses. (more…)


August 27, 2024

New award will support building pre-award research administration capacity at Kenyatta National Hospital in Kenya

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Credit: Karolina Kaboompics/Pexels

Congratulations to the research administrative team at Kenyatta National Hospital (KNH) and UW/Global WACh for receiving a National Institute of Allergy and Infectious Diseases (NIAID) G11 award to build pre-award grants management processes at KNH by leveraging an over 30 years long collaborative research partnership between KNH and UW. (more…)


August 26, 2024

Register for the DeWorm3 Study’s Primary Results Webinar on September 25, 2024

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Please join the DeWorm3 Study for a special scientific webinar to hear primary results on September 25th, 2024 from 1-3 PM UTC.

DeWorm3 has contributed a significant body of research on the feasibility of interrupting soil-transmitted helminth (STH) transmission through community-wide mass drug administration (cMDA) in Benin, Malawi and India. Visit their website to learn more about the objectives, team members, and publications.

Registration is required to receive the webinar link.  Click the flyer or scan the QR code below to register today! (more…)


August 23, 2024

Dr. Ruchi Tiwari receives NIH Postdoctoral Fellowship to study the association of maternal factors and child neurodevelopment in Kenya

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Congratulations to Dr. Ruchi Tiwari for receiving an NIH F32 Postdoctoral Fellowship Award that aims to enhance the research training of promising postdoctoral candidates who have the potential to become productive, independent investigators. This funding will allow her to continue training at Global WACh under the mentorship of Dr. Christine McGrath (Associate Professor, Global Health and Adjunct Associate Professor, Epidemiology) and faculty within the Gut Health and Child Survival scientific priority area.

Dr. Tiwari plays a leading role in pediatric studies on gut health and malnutrition in Kenya alongside investigators at the Kenya Medical Research Institute (KEMRI). These studies involve understanding the effects of breast-milk derived nutrition supplements (human milk oligosaccharides or HMOs) on infant health outcomes.  She will leverage her skills to assess how maternal factors that can be changed or controlled (e.g. stress, infection, and inadequate nutrition during and after pregnancy) influence child neurodevelopment at 2 years of age, with an important focus on the difference in the composition of HMOs by those factors. (more…)


August 9, 2024

Researchers present the latest science at the International Workshop on Pediatric HIV and AIDS 2024 in Germany

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Global WACh researchers attended the 25th International AIDS Society Conference (AIDS 2024) held from July 22-26 in Munich, Germany.  This year’s theme was “Put people first” — a call on the global HIV response to unite behind this simple principle and think of solutions from the point of view of those most affected. Researchers also attended the 16th International Workshop on HIV Pediatrics, a pre-conference event focused on the prevention and treatment of paediatric HIV infection with the overall objective to stimulate research that will advance prevention and treatment strategies for infants, children, and adolescents.

15 poster abstracts and one oral presentation from collaborative University of Washington and University of Nairobi/Kenyatta National Hospital studies featured the latest evidence related to health outcomes among children with different exposures to HIV, influential factors to early child neurodevelopment outcomes, key considerations for mobile reproductive health services for women living with HIV, implementation strategies for PrEP, and more. In addition to presenting research findings, some members received acclaimed awards at the conferences. (more…)


June 5, 2024

2nd annual Global WACh Student Poster Symposium celebrates and highlights student achievements over the academic year

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On May 28th in the Hans Rosling Center for Population Health, Global WACh hosted its second annual Student Poster Symposium featuring graduate student research aimed at improving the health and well-being of women, adolescents, and children. It was a celebratory end-of-year event to acknowledge students’ training, service, and achievement and give well wishes to those graduating UW.

This year’s symposium featured 14 posters by master’s and doctoral students and a postdoctoral fellow representing several departments and schools – Applied Bioengineering, Epidemiology, Global Health (General and Implementation Science tracks), Nursing, and Social Work. These included 90-hour capstone projects completed by students enrolled in the Global WACh Graduate Certificate Program, and master’s thesis and PhD dissertation-related posters by student supporting Global WACh’s research portfolio. Three posters were featured at scientific conferences over the academic year and shared with the UW global health community. (more…)


May 20, 2024

New grant supports scaling up integrated PrEP delivery to Kenyan pregnant and postpartum women

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Pregnancy is a high risk time for acquiring HIV. PrEP is a safe and effective prevention strategy to reduce women’s risk of acquiring HIV in pregnancy and postpartum and consequently vertical HIV transmission, improved health outcomes for both mother and child. In Kenya, this daily oral medication is being delivered in some regions during these life stages integrated into maternal and child (MCH) clinics, but scale-up has been sub-optimal.

Researchers from Global WACh and Kenyatta National Hospital have co-led implementation science studies focused on delivering integrated PrEP in routine MCH care, testing strategies to optimize delivery in western Kenyan counties. These represented the first and largest projects to deliver PrEP integrated into MCH clinics. Integrated PrEP delivery is now ready for scale up more broadly, which will require new implementation strategies to facilitate scale up. (more…)


April 29, 2024

Gut Health team shares experience supporting research consortiums at CUGH 2024

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Sonia Rao (Project Manager) and Alyson Shumays (Director of Research Operations) at CUGH 2024.

Global WACh team members, Sonia Rao and Alyson Shumays, attended the 2024 Consortium of Universities for Global Health (CUGH) Conference, held from March 7-10, in Los Angeles, CA to share what they’ve learned from supporting international research consortiums under the Gut Health and Child Survival research portfolio.

This year’s theme, “Global Health Without Borders: Acting for Impact,” created an environment for scientists, students and implementers from academia, NGOs, government, and the private sector to learn, share research, collaborate, and develop partnerships to address global health challenges. Global WACh featured two poster abstracts under one of seven subthemes, “Decolonizing – Reforming Global Health Equity, Justice, Global Health Education and Research.” Click the titles below to view the posters. (more…)


Researchers share pediatric and adolescent HIV and associated neurological research at CROI 2024

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Global WACh researchers participated in the 31st Conference on Retroviruses and Opportunistic Infections (CROI), held from March 3 to 6, in Denver, CO. They shared the latest discoveries in HIV and Co-Infectious Through the Lifecycle research portfolio on topics covering data-informed stepped adolescent HIV care approaches and neuropsychological outcomes in children associated with HIV.
See below for a list of poster abstracts to view. (more…)


April 22, 2024

Enterics for Global Health Consortium publishes a protocol supplement describing the study rationale and methods

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Sixteen articles authored by the Enterics for Global Health (EFGH) Shigella surveillance study Consortium were recently published in the March 2024 issue of Open Forum Infectious Diseases.

The Enterics for Global Health (EFGH) Shigella surveillance study is a multi-country diarrhea surveillance study that aims to generate key data to optimize the design and implementation of pivotal Shigella vaccine trials. The protocol supplement describes the study rationale and current Shigella vaccine landscape, Consortium governance structure, epidemiologic and laboratory methods, and country site descriptions (Bangladesh, The Gambia, Kenya, Malawi, Mali, Pakistan, and Peru).

(more…)



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