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January 27, 2021
Non-Congruent SARS-CoV-2 Waves in England
A study of SARS-CoV-2 infection waves in England noted different regional distributions of infections during the first (March-September 2020) and second (September 2020-onward) waves, with regions that experienced high mortality in the first wave experiencing lower mortality in the second. Greater first wave severity was also associated with slower second wave growth rate. Possible explanations…
Trends Regional Variation and Clinical Characteristics of COVID-19 Vaccine Recipients a Retrospective Cohort Study in 23.4 Million Patients Using OpenSAFELY
[Pre-print, not per-reviewed] A retrospective cohort study of electronic health record data from the National Health System in England from 23.4 million patients using the OpenSAFELY-TPP platform found that between December 8 and January 13, 2021, a total of 961,580 people received a COVID-19 vaccine. Of 1,160,062 patients aged 80 or over and not living…
Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2Kinetics and Correlates of the Neutralizing Antibody Response to SARS-CoV-2
[Pre-print, not per-reviewed] A longitudinal study of people who had recovered from COVID-19 (n=963) estimated a half-life of 7.7 months for anti-spike IgG and a half-life of 8.7 months for serum neutralization, with only 13% of individuals losing seroreactivity at ten months. In addition, around 3% of recovered patients demonstrated effective cross-neutralizing IgG antibodies to…
Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
[Pre-print, not per-reviewed] The SARS-CoV-2 variant B.1.1.7 (UK) was resistant to neutralization by several monoclonal antibodies (mAbs) targeting either the N-terminal domain (NTD) of the virus’s spike protein or its receptor-binding domain (RBD). This variant was also modestly more resistant to neutralization with convalescent plasma (about 3 fold) and sera from people who had received…
SARS-CoV-2 Infection and Mitigation Efforts among Office Workers, Washington, DC, USA
Two SARS-CoV-2 outbreaks in April, 2020 were identified among office workers in Washington, DC. The study identified two factors potentially associated with SARS-CoV-2 infection and transmission in the workplace: a significantly higher percentage of seropositive participants lived with someone who had a confirmed positive test result (13%) than those who were seronegative (1%), and more…
January 26, 2021
Evaluation of Seasonal Respiratory Virus Activity Before and After the Statewide COVID-19 Shelter-in-Place Order in Northern California
Infection rates for influenza and rhinovirus or enterovirus were significantly lower during March 25 to July 31, 2020 compared to the same time period during the past 5 years, according to a cohort study in California that included over 45,000 tests for the viral respiratory infections. This significant drop in infection rates coincided with implementation…
Association of Smoking and Cumulative Pack-Year Exposure With COVID-19 Outcomes in the Cleveland Clinic COVID-19 Registry
Greater pack-years of smoking was associated with worse COVID-19 outcomes in a cohort of 7,102 SARS-CoV-2 positive patients with full smoking information. Patients who smoked between 10-30 pack years had 1.4-times the odds of hospitalization compared to never smokers, while patients who smoked more than 30 pack-years had 2.3 -times the odds of hospitalization and…
Dynamic Public Perceptions of the Coronavirus Disease Crisis, the Netherlands, 2020
Monitoring of public perceptions during the first 3 months of the COVID-19 pandemic in the Netherlands found that respondents believed the risks associated with COVID-19 to be considerable, were positive about mitigation measures, trusted in information and response from authorities, and reported widespread adoption of protective measures. Differences in perception were mostly driven by factors…
Prioritization of Public Health Emergency Preparedness Funding Among Local Health Departments Preceding the COVID-19 Pandemic: Findings From NACCHO’s 2019 National Profile of Local Health Departments
A report from the National Association of County and City Health Official’s 2019 National Profile of Local Health Departments (LHDs) study shows that over half of LHDs had stagnant funding from the 2018 and 2019 fiscal years. Additionally, LHDs experienced a 16% decrease in full-time employees from 2008 to 2019, while the total number of…
Using Non-Pharmaceutical Interventions and High Isolation of Asymptomatic Carriers to Contain the Spread of SARS-CoV-2 in Nursing Homes
[Pre-print, not peer-reviewed] A pandemic influenza model with COVID-19 parameters applied to a nursing home setting showed that the attack rate was more sensitive to identification and isolation of asymptomatic cases than implementation of non-pharmaceutical interventions (NPIs). Varying NPI levels from baseline to rigorous measures had no significant effect on attack rate in a scenario…
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