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July 31, 2020
Post‐discharge Symptoms and Rehabilitation Needs in Survivors of COVID‐19 Infection: A Cross‐sectional Evaluation
Halpin et al. evaluated 100 COVID-19 survivors between 29 and 71 days after hospital discharge, including 32 people who had required ICU admission. Commonly reported symptoms among recovered patients included new illness-related fatigue (72% of the ICU group and 60% of the general admission group), breathlessness (66% of ICU group, 43% of general admission), and psychological distress (47% of ICU group, 24% of general admission). Survivors were also…
ChAdOx1 NCoV-19 Vaccine Prevents SARS-CoV-2 Pneumonia in Rhesus Macaques
A single dose of a vaccine similar to one previously discovered to protect against MERS was reported by van Doremalen et al. to produce neutralizing antibodies specific to SARS-CoV-2 in both mice and rhesus macaques. A booster shot significantly improved humoral immune response in macaques. The vaccine candidate is moving on to clinical trials. van Doremalen et al. (July 30, 2020). ChAdOx1 NCoV-19 Vaccine Prevents SARS-CoV-2…
Single-Shot Ad26 Vaccine Protects against SARS-CoV-2 in Rhesus Macaques
A single dose of an adenovirus serotype 26 vaccine expressing the SARS-CoV-2 spike protein induced robust neutralizing antibody responses and provided complete or near-complete protection after SARS-CoV-2 challenge in rhesus macaques. A version of the vaccine (Ad26.COV2.S) is currently being evaluated in clinical trials. Mercado et al. (July 30, 2020). Single-Shot Ad26 Vaccine Protects against SARS-CoV-2 in Rhesus…
Pooled RNA Sample Reverse Transcriptase Real Time PCR Assay for SARS CoV-2 Infection: A Reliable, Faster and Economical Method
Gupta et al. demonstrate that pool testing with 8 RNA samples analyzed with RT-qPCR can achieve a sensitivity of 95.4%, a specificity of 100% (280 samples tested: 40 positive and 240 negative). The authors conclude that the results of pool testing are not affected by the number of positive samples in a pool, suggesting the utility of pooled testing at…
Observations of the Global Epidemiology of COVID-19 from the Prepandemic Period Using Web-Based Surveillance: A Cross-Sectional Analysis
Identifying cases of COVID-19 using official websites, press releases, press conference transcripts, and social media feeds of national ministries of health, Dawood et al. conclude that travelers to China, Italy, or Iran accounted for almost two-thirds of the first reported cases in 99 other countries. Although clusters of household transmission associated with these index cases were common,…
SARS-CoV-2 Transmission and Infection Among Attendees of an Overnight Camp — Georgia, June 2020
An outbreak investigation in an overnight camp in Georgia found evidence of widespread transmission of SARS-CoV-2 among children of all ages. SARS-CoV-2 tests were available for 344 of 597 camp attendees, of whom 260 (76%) were positive. The overall attack rate was 44% (260 of 597). The attack rate was 51% among those aged 6–10 years, 44% among those aged 11–17 years, and 33%…
Enacting National Social Distancing Policies Corresponds with Dramatic Reduction in COVID19 Infection Rates
An analysis of daily COVID-19 case counts and average mobility data concluded that social distancing policies reduced global COVID-19 transmission by 65% over a two-week time period. McGrail et al. also conclude that statewide social distancing policies in the US correspond with reduced COVID-19 transmission, which was found to be proportional to reductions in mortality. McGrail et al. (July 30, 2020). Enacting National Social Distancing…
Enacting National Social Distancing Policies Corresponds with Dramatic Reduction in COVID19 Infection Rates
An analysis of daily COVID-19 case counts and average mobility data concluded that social distancing policies reduced global COVID-19 transmission by 65% over a two-week time period. McGrail et al. also conclude that statewide social distancing policies in the US correspond with reduced COVID-19 transmission, which was found to be proportional to reductions in mortality. McGrail et al. (July 30, 2020). Enacting National Social Distancing…
July 30, 2020
Notes from the Field: Rebound in Routine Childhood Vaccine Administration Following Decline During the COVID-19 Pandemic — New York City, March 1–June 27, 2020
Promotion of routine childhood vaccination to parents using methods including public service announcements and letters, guidance, and webinars for health care providers in New York City resulted in increased vaccine administration among persons aged <24 months starting the week of April 19–25, as the number of new COVID-19 cases declined, and vaccinations returned to a level comparable to 2019 beginning the week of May 17. The authors…
Assessing Racial and Ethnic Disparities Using a COVID-19 Outcomes Continuum for New York State
Using data from New York State, Holtgrave et al. found large excess burdens in COVID-19 fatality rates in Hispanic (3.5-fold higher) and Black populations (5.4-fold higher) compared to whites. The disparity in Hispanic people appears to be due to differences earlier on in infections, while disparities in Black people was driven by differences in both infection experience and in the unmet need for hospitalization. Holtgrave et al. (June 29, 2020). Assessing Racial and Ethnic Disparities Using a…
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