Article Summary
April 5, 2021
Outbreak of COVID-19 and Interventions in a Large Jail — Cook County, IL, United States, 2020
From March 1–April 30, 2020, 907 symptomatic and asymptomatic cases of SARS-CoV-2 infection were detected among detained persons (n = 628) and staff (n = 279) in a large jail in Chicago, representing an attributable risk of 13%. Of 1,256 detained persons tested for SARS-CoV-2, 628 (50%) were positive, among whom 479 (76%) were symptomatic. Early interventions included enhanced…
Community Transmission of SARS-CoV-2 Associated with a Local Bar Opening Event — Illinois, February 2021
Forty-six cases of COVID-19 were linked to an opening event for an indoor bar (accommodates ~100 persons) in rural Illinois in February 2021 (26 cases among patrons, 3 among staff, and 17 secondary cases). Among secondary cases, 12 occurred in eight households with children, two on a school sports team, and three in a long-term…
Factors Associated with Nonessential Workplace Attendance during the Covid-19 Pandemic in the UK in Early 2021 Evidence from Cross-Sectional Surveys
[Pre-print, not peer-reviewed] Among 1,422 people in the UK who reported they could work completely from home between January and February 2021, 26.8% of respondents reported attending their workplace at least once in the preceding week. Independent factors associated with non-essential workplace attendance included male gender (OR = 1.9), dependent children in the household (OR…
April 2, 2021
A Comprehensive Analysis of COVID-19 Transmission and Mortality Rates at the County Level in the United States Considering Socio-Demographics, Health Indicators, Mobility Trends and Health Care Infrastructure Attributes
Restricting county-level mobility through a stay-at-home-order (SAHO) with 50% compliance could result in a potential reduction of about 33% in daily COVID-19 cases, according to a modeling study. The models used smartphone mobility data and COVID-19 case and death data from March to August 2020 in 1,752 US counties that had at least 100 recorded…
COVID-19 in Individuals with Sickle Cell Disease/Trait Compared with Other Black Individuals
Persons diagnosed with COVID-19 and sickle cell disease (SCD) (n=312) were 2-times as likely to be hospitalized and develop pneumonia and 3-times as likely to develop pain compared to a propensity matched cohort of Black persons diagnosed with COVID-19 but without SCD or sickle cell trait (SCT). No significant differences were observed in case mortality…
SARS-CoV-2 Immune Evasion by Variant B.1.427B.1.429
[Pre-print, not peer-reviewed] The SARS-CoV-2 variant CAL.20C (also known as B.1.427/B.1.429, with key mutations S13I, W152C and L452R), which was first described in California, has plasma neutralizing activity that is 3- to 4-fold lower in individuals fully vaccinated with the Moderna or Pfizer-BioNTech vaccines compared to the wild-type SARS-CoV-2 strain. Reduction in neutralizing activity among…
Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
4 cases of possible SARS-CoV-2 reinfection characterized by a more severe second episode were identified in a case series in Brazil. In March 2020, all patients recovered from a mild course of COVID-19 and retested with negative PCR results during early April. In the last week of May, all 4 cases reported SARS-CoV-2 symptoms and…
Interim Report Safety And Immunogenicity Of An Inactivated Vaccine Against Sars-Cov-2 In Healthy Chilean Adults In A Phase 3 Clinical Trial
[Pre-print, not peer-reviewed] Interim results for the phase 3 clinical trial (n=397) of the SARS-CoV-2 inactivated-virus vaccine CoronaVac (SinoVac BioTech) conducted in Chile indicate the vaccine is safe to use and induces neutralizing antibody production against the SARS-CoV-2 spike protein. Among participants receiving two doses of the vaccine (n=239) or placebo (n=80) 2 weeks apart,…
The Neutralization Potency of Anti-SARS-CoV-2 Therapeutic Human Monoclonal Antibodies Is Retained against Novel Viral Variants
[Pre-print, not peer-reviewed] Neutralizing activity of four experimental monoclonal antibodies (mAbs) (MD65, MD62, MD29 and BL6) targeting the receptor-binding domain (RBD) of SARS-CoV-2 were largely retained against a panel of the top 10 RBD mutations including mutations found in several variants of concern. Rosenfeld et al. (Apr 1, 2021). The Neutralization Potency of Anti-SARS-CoV-2 Therapeutic Human…
A Method for Detection of SARS-CoV-2 RNA in Healthy Human Stool: A Validation Study
A modified RT-PCR test to detect SARS-CoV-2 RNA in human stool had 100% analytical sensitivity in 20 stool samples freshly spiked with inactivated SARS-CoV-2 material and a lower limit of detection (LLD) of 3,000 viral RNA copies per gram. Analytical sensitivity decreased two-fold after a single freeze-thaw cycle at -80 °C. The assay had 100%…
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