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Tag: clinical characteristics
September 22, 2020
SARS-CoV-2 Seroprevalence among Healthcare, First Response, and Public Safety Personnel, Detroit Metropolitan Area, Michigan, USA, May–June 2020
SARS-CoV-2 antibody testing of healthcare workers, first responders, and public safety personnel in EMS agencies and hospitals in Detroit (May-June 2020) indicated that 7% of participants had SARS-CoV-2 antibodies. Seropositivity was associated with exposure to SARS-CoV-2–positive household members (aOR=6.18) and working within 15 km of Detroit (aOR=5.60). Nurse assistants (aOR=1.88) and nurses (aOR=1.52) had higher…
September 18, 2020
Recovered COVID-19 Patients with Recurrent Viral RNA Exhibit Lower Levels of Anti-RBD Antibodies
Patients who recovered from COVID-19 (n=47) and had a recurrent positive SARS-CoV-2 RNA test had significantly lower levels of anti-receptor binding domain (RBD) IgG antibodies than persistently RNA-negative patients (p=0.013). The authors conclude that this suggests that anti-RBD IgG levels could predict recovered patients who are at risk of viral rebound. Liu et al. (Sept…
September 17, 2020
Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes
Older age (≥70 years) and a high serum lactate dehydrogenase (LDH) level significantly predicted mortality among hospitalized COVID-19 patients with diabetes in South Korea. Diabetes was present in 55 (17%) of 324 patients who were hospitalized with COVID-19 at two tertiary healthcare facilities. The mortality rate was much higher among patients with diabetes than among…
September 15, 2020
Fasting Blood Glucose Level Is a Predictor of Mortality in Patients with COVID-19 Independent of Diabetes History
Elevated fasting blood glucose (≥ 7.0 mmol/L), an indicator of pre-diabetes, was associated with COVID-19 mortality (HR=2.2), independent of diabetes history, in a Chinese cohort of 941 hospitalized patients. The authors conclude fasting blood glucose could be used to screen high-risk patients. Cai et al. (Sept 10, 2020). Fasting Blood Glucose Level Is a Predictor…
Comorbidities Associated with Mortality in 31,461 Adults with COVID-19 in the United States: A Federated Electronic Medical Record Analysis
Older age, male sex, and being Black or African American were significantly associated with mortality from COVID-19 across different age groups in a retrospective cohort study of patients age 18-90 years in the US (n=31,461). Comorbidities associated with higher odds of death varied across age groups and included heart attack history, congestive heart failure, dementia,…
September 14, 2020
Change in Donor Characteristics and Antibodies to SARS-CoV-2 in Donated Blood in the US, June-August 2020
Routine testing of blood donated at American Red Cross centers since June 15, 2020 (n=953,926 donations) found that 1.8% of donations tested positive for SARS-CoV-2 antibodies, with an increase in seropositivity over the study period. Blood from first-time donors was more likely to test positive than blood from repeat donors (3% vs. 1.6%, p<0.001). The…
September 11, 2020
Cardiovascular Magnetic Resonance Findings in Competitive Athletes Recovering From COVID-19 Infection
• Among 26 competitive college athletes who had tested positive for SARS-CoV-2 11-53 days earlier and had not require hospitalization, 4 (15%) had cardiac MRI findings suggestive of myocarditis (heart muscle inflammation) and 8 (31%) athletes exhibited late gadolinium enhancement (LGE) without T2 elevation, suggestive of prior myocardial injury. Cardiac ventricular function was within normal…
Elevated D-Dimers and Lack of Anticoagulation Predict PE in Severe COVID-19 Patients
Pulmonary embolism (PE) was diagnosed in 44/162 (27%) patients hospitalized with COVID-19 in a university hospital in France who had severe respiratory disease or rapid clinical worsening and who received computed tomography pulmonary angiography. Elevated D-dimer level (OR=4.0 per additional quartile) and lack of anticoagulant therapy (OR=4.5) were associated with confirmed PE. D-dimer level >2590…
Massachusetts General Hospital Covid-19 Registry Reveals Two Distinct Populations of Hospitalized Patients by Race and Ethnicity
[Pre-print, not peer reviewed] Among hospitalized patients with COVID-19 (n=866) at Massachusetts General Hospital from March 11 to May 4, Hispanic patients were younger and had fewer comorbidities compared to non-Hispanic white patients. Despite comparable rates of ICU care and death, a greater proportion of Hispanic patients recovered by 14 days after presentation. Bassett et…
September 10, 2020
Clinical Characteristics and Outcomes of Immunosuppressed Patients Hospitalized with COVID-19: Experience from London
• In a cohort study of 981 confirmed COVID-19 patients consecutively hospitalized at a large North West London hospital between March 12 and April 15, taking high dose immunosuppressive medications, such as for autoimmune disease or solid organ transplant, was associated with significantly higher mortality rates, supporting the current UK government’s early isolation (“shielding”) policy…
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