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Tag: sequelae
March 2, 2021
Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19
[Pre-print, not peer-reviewed] A longitudinal study in California found that SARS-CoV-2-specific T cell responses remained largely stable up to 9 months following SARS-CoV-2 infection (n=70). Stronger CD4+ T cell responses were associated with initial disease severity as well as neutralizing antibody levels, whereas pre-existing lung disease predicted long-term CD8+ T cell responses. While 36% of…
February 24, 2021
Patients with Uncomplicated COVID-19 Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale during a Global Pandemic
Persistent COVID-19 symptoms at 3-4 month after infection were found in 82% of patients who had been hospitalized and 64% of those who had not been hospitalized, the most prevalent of which included fatigue and difficulty breathing (dyspnea). Patients were recruited from clinical trials occurring at a single center (Stanford). The majority had mild/moderate COVID-19…
February 22, 2021
Sequelae in Adults at 6 Months After COVID-19 Infection
A longitudinal prospective cohort study of adults with laboratory-confirmed SARS-CoV-2 infection in Washington State, and a concurrent cohort of healthy (control) patients, found that persistent symptoms were reported up to 9 months after initial infection by 17 of 64 patients (27%) aged 18 to 39 years, 25 of 83 patients (30%) aged 40 to 64…
February 13, 2021
Cardiovascular Sequalae in Uncomplicated COVID-19 Survivors
Evaluation for cardiac abnormalities was performed at 1 to 4 weeks after hospital discharge among 97 survivors of non-severe COVID-19 who had been hospitalized but did not require intensive care. The abnormalities identified included sinus bradycardia <50 beats per minute (7%), newly detected T-wave abnormality (8%), elevated troponin level (6%), newly detected atrial fibrillation (1%),…
January 29, 2021
More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
[Pre-print, not peer-reviewed] Eighty percent (95%CI: 65% to 92%) of persons infected with SARS-CoV-2 developed one or more long-term symptoms, according to a systematic review and meta-analysis (n=47,910 patients) assessing long-term effects of COVID-19. Follow-up time of study participants ranged from 15 to 110 days post-viral infection. The age of the study participants ranged between…
January 28, 2021
Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge
Respiratory, physical, and psychological sequelae were common 3-4 months after hospital discharge in an Italian cohort of COVID-19 survivors (n=238, median age = 61 [IQR 50-71]). 113 of 219 patients (52%) had a significant reduction in lung function measured by diffusing lung capacity for carbon monoxide (80% of expected value), and 128 (54%) patients had…
January 11, 2021
6-Month Consequences of COVID-19 in Patients Discharged from Hospital: A Cohort Study
A cohort study following patients recovering from COVID-19 in Wuhan, China found that fatigue or muscle weakness (63%) and sleep difficulties (26%) were the most commonly reported symptoms during the 6 months post-discharge. Anxiety or depression was reported among 23% of patients. In a comparison of laboratory values during the acute phase of illness versus…
December 28, 2020
Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact
[pre-print; not peer-reviewed] In an international web-based survey of people with suspected or confirmed COVID-19 with illness lasting >28 days (n=3,762) identified 205 symptoms across 10 organ systems. In those who recovered in less than 90 days, the average number of symptoms peaked at week 2, as compared to a peak in month 2 among…
December 21, 2020
Increased Care at Discharge from COVID-19: The Association between Pre-Admission Frailty and Increased Care Needs after Hospital Discharge; a Multicentre European Observational Cohort Study
Among patients hospitalized with COVID-19, pre-admission frailty was strongly associated with the need for an increased level of care at discharge in a multicenter observational cohort study in Europe. Among 831 discharged patients (median age = 71 years, 44.4% women), the median length of hospital stay was 12 days, 23.2% had increased care needs at discharge. Vilches-Moraga…
December 18, 2020
Prevalence and Risk Factors of Disability and Anxiety in a Retrospective Cohort of 432 Survivors of Coronavirus Disease-2019 (Covid-19) from China
A multi-center retrospective cohort study of COVID-19 survivors in China found that a significant proportion experienced disability and anxiety after discharge from the hospital. Prevalence of at least one problem on a measure assessing independent living skills (Lawton IADL) was 37%, dependence in personal care and mobility (as assessed by the Barthel Index) was present…
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