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Topic: Clinical Characteristics and Health Care Setting
June 15, 2021
Persistent COVID-19 Symptoms Are Highly Prevalent 6 Months after Hospitalization: Results from a Large Prospective Cohort
Nearly 1 in 4 individuals hospitalized for COVID-19 had 3 or more persistent symptoms 6 months after hospital admission in a cohort study in France (n=1,137). Presence of 3 or more symptoms at 6 months was more common among women, those with 3 or more symptoms at admission, and those who were admitted to the…
June 14, 2021
Comparison of Symptoms and RNA Levels in Children and Adults With SARS-CoV-2 Infection in the Community Setting
SARS-CoV-2 RNA levels, as determined by cycle threshold (Ct) values, were significantly higher in symptomatic compared to asymptomatic individuals, and no significant differences in RNA levels were detected between adults and children, according to results from a community-based cross-sectional study in King County, Washington. Among 555 SARS-CoV-2–positive participants, 47 of 123 children (38%) were asymptomatic…
International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries
A cohort study of children and adolescents (n=671) from France, Germany, Spain, Singapore, the UK, and the US found varying trends in COVID-19 hospitalizations and complications between countries, with hospitalizations in the cohort mirroring those of national-level pediatric hospitalization trends for most countries with available data. Laboratory values for 16 assays were analyzed, which indicated…
Risk Factors for Hospitalization Disease Severity and Mortality in Children and Adolescents with COVID-19 Results from a Nationwide German Registry
[Pre-print, not peer-reviewed] A cohort study of children and adolescents (n=1,501) who were admitted to the hospital between March 18, 2020 and April 30, 2021 in Germany and who tested positive for SARS-CoV-2 found that although approximately half of the cohort was not admitted to the hospital due to COVID-19, 72% had infection-related symptoms during…
June 11, 2021
Dynamic Changes in the Immune Response Correlate with Disease Severity and Outcomes During Infection with SARS-CoV-2
A small, single center study of persons hospitalized with COVID-19 in China (N=74) identified innate and adaptive immunological differences between patients with severe and non-severe disease. Specifically, patients with severe disease had lower baseline lymphocyte counts, higher neutrophil to lymphocyte ratios, and lower eosinophil counts. T-cell, B-cell, and natural killer cells were also lower among…
Incidence of Multisystem Inflammatory Syndrome in Children Among US Persons Infected With SARS-CoV-2
A retrospective cohort study of persons with SARS-CoV-2 infection diagnosed between April and June 2020 in 7 US states identified 248 cases of multisystem inflammatory syndrome in children (MIS-C) in persons <21 years of age. The corresponding incidence of MIS-C was 5.1 per 100,000 person-months and 316 persons per 1,000,000 (0.0003%) SARS-CoV-2 infections. Incidence was…
June 10, 2021
Clinical and Molecular Characteristics of COVID-19 Patients with Persistent SARS-CoV-2 Infection
COVID-19 patients with extended viral shedding for >45 days (n=12) had lower levels of inflammatory cytokines/chemokines (IL-2, TNF, and LT-α) compared to an age- and sex-matched cohort of COVID-19 patients in whom viral shedding resolved within 21 days (n=39). Single-cell RNA sequencing from peripheral mononuclear blood cells from a subset of patients showed suppressed T…
June 9, 2021
Inflammatory Biomarkers in COVID-19-Associated Multisystem Inflammatory Syndrome in Children, Kawasaki Disease, and Macrophage Activation Syndrome: A Cohort Study
Pediatric patients diagnosed with Multisystem Inflammatory Syndrome in Children (MIS-C) (n=19) had higher median concentrations of interferon-induced monokines (CXCL9) compared to patients with Kawasaki Disease (n=9), another hyperinflammatory syndrome, in a cohort study in Ohio. Rodriguez-Smith et al. (June 9, 2021). Inflammatory Biomarkers in COVID-19-Associated Multisystem Inflammatory Syndrome in Children, Kawasaki Disease, and Macrophage Activation Syndrome:…
Risk Factors Associated With COVID-19 Outcomes Among People With Intellectual and Developmental Disabilities Receiving Residential Services
In adults with intellectual and developmental disabilities (IDD) receiving residential services in New York City (n=543), age and pre-existing conditions, such chronic kidney disease, were associated with a COVID-19 diagnosis. These risk factors were similar to those reported in the general population. Diagnosis of Down syndrome was also associated with a COVID-19 diagnosis (OR=3), while…
June 8, 2021
Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children
29% of pediatric US COVID-19 patients aged ≤18 years (n=43,465) had at least one underlying medical condition, according to an analysis of data collected from more than 800 US hospitals from March 2020 to January 2021. The most common diagnosed conditions were asthma (10%), neurodevelopmental disorders (4%), anxiety and fear-related disorders (3%), depressive disorders (3%),…
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