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Topic: Clinical Characteristics and Health Care Setting
March 9, 2021
Persistence of Symptoms up to 10 Months Following Acute COVID-19 Illness
[Pre-print, not peer-reviewed] Among US individuals with a history of symptomatic COVID-19 (n=6,211) participating in a 10-wave survey between June 2020 to January 2021, 80% reported recovering within less than 2 months and 8% reported experiencing symptoms for 2 months or more. 3% and 2% reported being symptomatic for ≥4 months and ≥6 months, respectively….
Infection Sustained by Lineage B.1.1.7 of SARS-CoV-2 Is Characterised by Longer Persistence and Higher Viral RNA Loads in Nasopharyngeal Swabs
Individuals infected with the SARS-CoV-2 B.1.1.7 variant may have higher viral loads and longer viral shedding duration, according to a surveillance study in Italy. 313 individuals with sequencing-confirmed B.1.1.7 infection had lower median cycle thresholds of the SARS-CoV-2 nucleocapsid (N) protein (indicating higher viral loads) compared to individuals without B.1.1.7 infection (15.8 vs 16.9). Among…
March 8, 2021
Outcomes and Mortality Among Adults Hospitalized With COVID-19 at US Medical Centers
A cohort study of 192,550 adults with COVID-19 admitted to US medical centers between March 1 and August 31, 2020 revealed that in-hospital mortality was 13.6% for the cohort. Mortality increased with age; 1.4% of patients aged 18 to 29 years died while 26.6% 80 years or older died. Among ICU patients, 27.8% died. However,…
Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020
Among 148,494 U.S. adults diagnosed with COVID-19 between March-December 2020, individuals with a BMI near the threshold between healthy weight and overweight generally had the lowest risks for hospitalization, ICU admission, and death, with higher risks associated with higher BMI. Obesity was a risk factor for hospitalization and death, particularly among adults aged <65 years….
March 5, 2021
Articles Risk of Adverse Outcomes in Patients with Underlying Respiratory Conditions Admitted to Hospital with COVID-19: A National, Multicentre Prospective Cohort Study Using the ISARIC WHO Clinical Characterisation Protocol UK
Asthma was associated with a higher likelihood over developing more severe COVID-19. Among more than 75,000 patients hospitalized with COVID-19 in the UK from January to August 2020, patients with asthma were 1.2-times as likely to receive critical care compared to patients without underlying respiratory conditions, regardless of comorbidities and disease severity at admission. Patients…
March 4, 2021
Alcohol Withdrawal Rates in Hospitalized Patients During the COVID-19 Pandemic
A cohort study in a hospital system in Delaware found an increase in rates of alcohol withdrawal (AW) during 2020 compared to 2019. Incidence in 2020 peaked at 1.8-fold higher than 2019 during the last 2 weeks of the stay-at-home order. AW rates remained elevated during the reopening period. Sharma et al. (Mar 3, 2021). Alcohol…
Prevalence of Inflammatory Heart Disease Among Professional Athletes With Prior COVID-19 Infection Who Received Systematic Return-to-Play Cardiac Screening
Cardiac screening among professional athletes recovering from mild COVID-19 or asymptomatic SARS-CoV-2 infection (n=789) identified 5 athletes (0.6%) with imaging evidence of inflammatory heart disease that resulted in restriction from play. Screening occurred a median of 19 days after a positive SARS-CoV-2 PCR test, though 202 (26%) athletes were diagnosed by antibody testing alone. 460…
March 2, 2021
Risk Factors for Illness Severity among Pregnant Women with Confirmed SARS-CoV-2 Infection – Surveillance for Emerging Threats to Mothers and Babies Network 20 State Local and Territorial Health Departments March 29 2020 -January 8 2021
[Pre-print, not peer-reviewed] Risk factors for developing moderate-to-severe COVID during pregnancy included age 30-39 years, Black/Non-Hispanic race/ethnicity, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, cardiovascular disease, pre-gestational diabetes or gestational diabetes. The study was conducted by the CDC from March 2020 to January 2021 and included 5,963 pregnant women with laboratory confirmed SARS-CoV-2…
March 1, 2021
Exploratory Analysis of Immunization Records Highlights Decreased SARS-CoV-2 Rates in Individuals with Recent Non-COVID-19 Vaccinations
An exploratory analysis of immunization records from the Mayo clinic found that receipt of multiple vaccines within the past five years were associated with protection from SARS-CoV-2 infection. In an analysis of medical records from 137,037 individuals tested for SARS-CoV-2 by PCR , receipt of vaccines for polio, Haemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), Varicella,…
February 25, 2021
Distinguishing Active Pediatric COVID-19 Pneumonia from MIS-C
A retrospective study among pediatric patients in Alabama (n=111, age ≤22 years) identified 100 patients with COVID-19 and 11 with multisystem inflammatory syndrome in children (MIS-C). Fever, rash, conjunctivitis, and gastrointestinal symptoms were more common in the MIS-C patients, while COVID-19 patients more commonly presented with respiratory symptoms. Patients were more likely to be males…
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