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Topic: Clinical Characteristics and Health Care Setting
March 18, 2021
Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19
51% of COVID-19 survivors reported at least 1 new-onset symptom at four months after hospitalization that was not previously present in a cohort study (n=478) in France. New-onset symptoms included fatigue (31%), cognitive symptoms (21%), and shortness of breath (16%). In a subset of patients with further evaluations (n=177, including 97 of 142 former ICU…
Hospital Policies During COVID-19
Visitor restriction policies varied significantly among the 70 largest US hospitals during the first 3 months of the COVID-19 pandemic. 65 of the hospitals had public-facing visitor restriction policies. While 49 of these policies had general “no-visitor” statements, 16 allowed at least 1 visitor to accompany all patients. 63 policies included exceptions to their visitor…
March 17, 2021
Nursing Home Characteristics Associated With Resident COVID-19 Morbidity in Communities With High Infection Rates
A study of residents of nursing homes (NHs) in communities with high SARS-CoV-2 infection rates found that NHs with more COVID-19 cases have residents who were older and had higher activities of daily living scores. Additionally, higher incidence NHs had a lower proportion of white residents and a higher proportion of residents who were insured…
March 15, 2021
Comparison of Clinical Characteristics and Disease Outcome of COVID-19 and Seasonal Influenza
Compared to patients with seasonal influenza treated in hospital settings, patients with COVID-19 tended to be younger (median age 59 vs 66), had fewer comorbidities at baseline with a lower Charlson Comorbidity Index (mean 3.0 vs 4.0), had a longer duration of hospitalization (mean 25.9 vs 17.2 days), more frequently needed oxygen therapy (61% vs 40%) and…
March 12, 2021
COVID-19 Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients
Among patients with COVID-19 who were receiving mechanical ventilation (n=396), patients with COVID-19 associated pulmonary aspergillosis (CAPA) had higher odds of worse disease outcome, required longer time to improvement and had an increased hazard of advancing disease severity compared to those without CAPA. Although there were no differences in mortality, patients with CAPA required significantly…
Prevention of COVID-19 among older adults receiving pneumococcal conjugate vaccine suggests interactions between Streptococcus pneumoniae and SARS-CoV-2 in the respiratory tract
Receipt of the 13-valent pneumococcal conjugate vaccine (PCV13) was associated with lower incidence of any COVID-19 diagnosis, COVID-19 hospitalization, and fatal COVID-19 hospitalization after accounting for potential sources of confounding, according to a cohort study of 531,033 US adults aged ≥65 years. Lewnard et al. (Mar 9, 2021). Prevention of COVID-19 among older adults receiving pneumococcal…
Serial interval and incubation period of COVID-19: a systematic review and meta-analysis
A systematic review and meta-analysis found that the average time between the onset of COVID-19 symptoms in an index case and the onset of symptoms in a secondary case (serial interval) was 5.2 days and the average time from infection until symptom onset (incubation period) was 6.5 days. Alene et al. (Mar 11, 2021). Serial interval…
March 11, 2021
Characteristics of and Mortality Associated With Diabetic Ketoacidosis Among US Patients Hospitalized With or Without COVID-19
30% of patients with COVID-19 and diabetic ketoacidosis (DKA) died in the hospital (64 of 210) compared to 5% of patients with DKA but without COVID-19 (262 of 4,819), according to a cohort study of 5,029 patients admitted to 175 hospitals across the US. Conducted between February to September 2020, the study also found that…
Risk of Mortality in Patients Infected with SARS-CoV-2 Variant of Concern 202012/1: Matched Cohort Study
The SARS-CoV-2 B.1.1.7 variant was associated with an overall 1.6-fold increase in risk of death compared to previously circulated variants, according to a matched cohort study (n=54,906) of patients diagnosed with SARS-CoV-2 infection in the UK between October 2020 to January 2021. Risk of death was not significantly increased within 14 days of follow-up after…
March 10, 2021
Factors Linked to Severe Outcomes in Multisystem Inflammatory Syndrome in Children (MIS-C) in the USA: A Retrospective Surveillance Study
A retrospective surveillance study of multisystem inflammatory syndrome in children (MIS-C, n = 1,080 patients) found that ICU admission was more likely in patients aged 6–12 years (aOR = 1.9) and 13–20 years (aOR = 2.6) compared with patients 0–5 years, and more likely in non-Hispanic Black than non-Hispanic White patients (aOR = 1.6). Patients…
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