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Topic: Clinical Characteristics and Health Care Setting
February 19, 2021
COVID-19 Prevalence and Mortality Among Schizophrenia Patients: A Large-Scale Retrospective Cohort Study
A large-scale retrospective cohort study in Israel found that individuals with schizophrenia (n = 25,539) were twice as likely to be hospitalized for COVID-19 (OR = 2.2), even after controlling for sociodemographic and clinical risk factors (OR = 1.9). They were also three times more likely to experience COVID-19 mortality (OR = 3.3) compared to…
HIV-1 Infection Does Not Change Disease Course or Inflammatory Pattern of SARS-CoV-2-Infected Patients Presenting at a Large Urban Medical Center in New York City
People living with HIV (PWH) with COVID-19 were more likely to be admitted from the emergency department when compared to patients without HIV (91% vs 71%), according to a retrospective cohort study in New York. After admission, there was no statistically significant difference in 30-day mortality rate or mechanical ventilation rate. Clinical characteristics, including age,…
February 18, 2021
Innate Cell Profiles during the Acute and Convalescent Phase of SARS-CoV-2 Infection in Children
Cell profiles of children (n=48, aged <18 years) with clinically mild SARS-CoV-2 were characterized by reduced circulating subsets of monocytes, dendritic cells, and natural killer cells during the acute phase of infection. In contrast, adults with SARS-CoV-2 infection (n=70) showed reduced proportions of non-classical monocytes only. Both children and adults who were exposed to SARS-CoV-2…
Surge Effects and Survival to Hospital Discharge in Critical Care Patients with COVID-19 during the Early Pandemic: A Cohort Study
The odds of surviving to hospital discharge among critical COVID-19 patients increased over time in a retrospective cohort study (n=620) in the western US from February to May 20. Overall, 403 (65%) patients were discharged alive, increasing from 60% to 68% between the first 2 weeks of the study period to the last 2 weeks….
Viral Load of SARS-CoV-2 in Adults during the First and Second Wave of COVID-19 Pandemic in Houston, TX: The Potential of the Super-Spreader
Analysis of RT-PCR test results in Houston, Texas across two epidemiologic waves from March to August 2020 (n=11,64 samples) show that an increase in the viral load among the samples tested that week preceded the peak of each wave by approximately two weeks. This relationship was more evident during the second wave when the city…
February 17, 2021
Characteristics and Factors Associated with COVID-19 Infection, Hospitalization, and Mortality Across Race and Ethnicity
[Pre-print, not peer-reviewed] A retrospective cohort study of 570,298 patients tested for SARS-CoV-2 with known race/ethnicity, found that people from racial/ethnic minority groups represented 50% of infections but only 18% of total tests. The data were drawn from a large health system spanning California, Oregon, and Washington between March 1 and December 31, 2020. People…
Comparison of Acute Pneumonia Caused by SARS-COV-2 and Other Respiratory Viruses in Children: A Retrospective Multi-Center Cohort Study during COVID-19 Outbreak
Children with COVID-19 pneumonia were older (median age of 6.3 vs. 3.2 years) and had less severe disease than children with other causes of pneumonia, according to a retrospective multi-center cohort study. Children in the COVID-19 pneumonia cohort had a lower proportion of severe cases (1 of 40 vs. 38 of 284), and fewer cases…
February 13, 2021
Cardiovascular Sequalae in Uncomplicated COVID-19 Survivors
Evaluation for cardiac abnormalities was performed at 1 to 4 weeks after hospital discharge among 97 survivors of non-severe COVID-19 who had been hospitalized but did not require intensive care. The abnormalities identified included sinus bradycardia <50 beats per minute (7%), newly detected T-wave abnormality (8%), elevated troponin level (6%), newly detected atrial fibrillation (1%),…
Association of Mortality and Aspirin Prescription for COVID-19 Patients at the Veterans Health Administration
Among Veterans with confirmed cases of COVID-19, preexisting aspirin prescription was associated with a statistically and clinically significant decrease in overall mortality at 14-days (OR=0.38) and at 30-days (OR=0.38). Participants were matched on age, gender, and clinical characteristics for the analysis. The authors speculate that aspirin’s systemic antithrombotic effects could disrupt the risk of thrombotic…
February 11, 2021
Factors Associated With Racial Differences in Deaths Among Nursing Home Residents With COVID-19 Infection in the US
COVID-19-associated deaths in the US were higher in nursing homes with greater proportions of non-white residents, according to a cross-sectional survey involving 13,312 nursing homes. Nursing homes with the lowest quintile proportion of white residents (<60%) had 4 more deaths on average from January to September 2020, corresponding to 3.3-fold higher deaths than those with…
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