Result for
Topic: Clinical Characteristics and Health Care Setting
February 11, 2021
Effect of the New SARS-CoV-2 Variant B.1.1.7 on Children and Young People
The clinical course of SARS-CoV-2 infection among children may be similar when infection occurs with the B.1.1.7 variant versus the original strain, according to an analysis of two cohorts of children admitted to King’s College Hospital for COVID-19. The B.1.1.7. variant accounted for ~70% of SARS-CoV-2 infections in London by January 2021 and the two…
Symptoms and Laboratory Manifestations of Mild COVID-19 in a Repatriated Cruise Ship Cohort
Among 49 passengers traveling from Uruguay to Australia on a cruise ship with high COVID-19 incidence in April 2020, 42% were asymptomatic and only 15% of symptomatic cases reported fever. Serial respiratory and rectal swabs were positive for 10% and 5% of participants, respectively, after a median of 3 weeks post-symptom onset. The authors suggest…
February 10, 2021
Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)
An observational cohort study among pregnant patients (n=1,219 patients, 47% asymptomatic, 27% mild illness, 14% moderate, 8% severe, and 4% critical) who tested positive for SARS-CoV-2 found that pregnant patients with severe-critical COVID-19 were at higher risk of perinatal complications compared to those with mild or asymptomatic infection, including 6% incidence of venous thromboembolism among…
Cerebrospinal Fluid in COVID-19: A Systematic Review of the Literature
A systematic review of cerebrospinal fluid (CSF) testing for potential viral neuroinvasion in patients with COVID-19 showed that among 303 patients who had CSF SARS-CoV-2 PCR testing, 16 (5%) were positive, and 75% of these positive patients were hospitalized due to neurological symptoms. The authors concluded that detection of SARS-CoV-2 in CSF via PCR is…
February 9, 2021
A SARS-CoV-2 Cluster in an Acute Care Hospital
Despite mature infection control policies, a cluster of SARS-CoV-2 infections among 14 patients and 38 staff members at Brigham and Women’s Hospital in Boston was confirmed using whole-genome sequencing. The index patient was admitted for an elective procedure and tested PCR-negative twice, then was removed from isolation and subsequently infected roommates and staff in the…
Impact of SARS-CoV-2 Infection on Pregnancy Outcomes: A Population-Based Study
The overall rate of pregnancy complications was similar between SARS-CoV-2 infected and non-infected women in a population-based study in Spain (n=2,225). Pregnancy complications (miscarriage, preeclampsia, preterm delivery, perinatal death, small-for-gestational age, or neonatal admission) occurred in 43 (14%) of 317 SARS-CoV-2-infected women compared to 268 (14%) of 1,908 non-infected women. However, higher rates of preterm…
February 5, 2021
Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults
A multicenter study of SARS-CoV-2 cases (n=5,544) confirmed by RT-PCR assay found no significant differences in viral concentration (as measured by Ct values) across different age groups. In particular, the children less than 5 years old did not display higher nasopharyngeal viral loads than older children or adults. Madera et al. (Feb 4, 2021). Nasopharyngeal…
February 4, 2021
COVID-19 Outcomes Among Persons Living With or Without Diagnosed HIV Infection in New York State
COVID-19 related outcomes were worse among persons living with diagnosed HIV than those without HIV in New York State between March to June 2020, according to population-level comparisons using matched data from HIV surveillance, COVID-19 laboratory-confirmed diagnoses, and hospitalization databases. Though persons living with and without diagnosed HIV had similar COVID-19 diagnosis rates, among persons…
Increased Hazard of Death in Community-Tested Cases of SARS-CoV-2 Variant of Concern 20201201
[Pre-print, not peer reviewed] The SARS-CoV-2 B.1.1.7 variant (first identified in the UK) was estimated to increase the risk of death by 30%, based on an analysis of a database of SARS-CoV-2 community test results in the UK. This dataset represents approximately 47% of all SARS-CoV-2 community tests and 7% of COVID-19 deaths in England…
February 3, 2021
Gastroenterology Manifestations and COVID-19 Outcomes: A Meta-Analysis of 25,252 Cohorts among the First and Second Waves
Twenty percent of COVID-19 patients presented with GI symptoms, according to a meta-analysis. In 125 studies included in the analysis, GI symptoms upon presentation to care included loss of appetite (20%), altered sense of taste or loss of taste (15%), diarrhea (13%), nausea (10%), and vomiting of blood (9%). Over 26% of patients had confirmed…
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