Result for
Topic: Clinical Characteristics and Health Care Setting
February 2, 2021
Genetically Predicted Serum Vitamin D and COVID-19 a Mendelian Randomization Study
[Pre-print, not peer reviewed] Long-term vitamin D nutritional status does not causally affect susceptibility to SARS-CoV-2 infection or more severe COVID-19 disease course, according to a two-sample Mendelian randomization study of a European cohort. No elevation in the risk of COVID infection, hospitalization, or progression to severe COVID-19 was associated with serum vitamin D status…
Viral Sequencing Reveals US Healthcare Personnel Rarely Become Infected with SARS-CoV-2 through Patient Contact
[Pre-print, not peer reviewed] Patient to healthcare worker (HCW) transmission could be rare, according to viral sequencing of 32 SARS-CoV-2 infection clusters involving 96 HCWs in the Upper Midwest. Using 140 possible patient contacts, only 4% of HCW infections were clearly traced to a patient source. In comparison, 10% could be traced to a coworker,…
February 1, 2021
Quantification of Occupational and Community Risk Factors for SARS-CoV-2 Seropositivity Among Health Care Workers in a Large U.S. Health Care System
Adjusted SARS-CoV-2 seropositivity was estimated to be 3.8% among healthcare workers (n=10,275) at a large Atlanta health care center who participated in a survey from April-June 2020. Odds of infection were higher among those with community contact with a person known or suspected to have COVID-19 (aOR = 1.9), community COVID-19 incidence (aOR = 1.5),…
Pre-Pandemic Psychiatric Disorders and Risk of COVID-19: A UK Biobank Cohort Analysis
A cohort study using data from the UK Biobank and Public Health England found an increased risk of COVID-19 infection (OR = 1.44), hospitalization (OR = 1.55), and death (OR = 2.03) among individuals with psychiatric conditions diagnosed before the pandemic, including depression, stress-related disorder, and substance use. The associations were stronger among individuals who…
January 29, 2021
More than 50 Long-term effects of COVID-19: a systematic review and meta-analysis
[Pre-print, not peer-reviewed] Eighty percent (95%CI: 65% to 92%) of persons infected with SARS-CoV-2 developed one or more long-term symptoms, according to a systematic review and meta-analysis (n=47,910 patients) assessing long-term effects of COVID-19. Follow-up time of study participants ranged from 15 to 110 days post-viral infection. The age of the study participants ranged between…
The effect of SARS-CoV-2 variant B.1.1.7 on symptomatology re-infection and transmissibility
[Pre-print, not peer-reviewed] No association was found between the proportion of the UK SARS-CoV-2 variant B.1.1.7 in circulation and reported disease severity, according to data obtained from reporting of symptoms and test results via the COVID Symptom Study application. The authors controlled for both demographic characteristics (age, sex) and seasonal variables (temperature, humidity). No effects…
Outcomes of COVID-19 Among Hospitalized Health Care Workers in North America
Health care workers (HCWs) hospitalized with COVID-19 were less likely to require admission to an intensive care unit (aOR, 0.6; 95% CI, 0.3-0.9) and less likely to be admitted for 7 days or longer (aOR, 0.5; 95% CI, 0.3-0.8) when compared to matched non-healthcare workers in a retrospective, observational cohort involving 36 North American centers….
January 28, 2021
Disease Severity, Pregnancy Outcomes and Maternal Deaths among Pregnant Patients with SARS-CoV-2 Infection in Washington State
Among a cohort of 240 pregnant patients with SARS-CoV-2 infection in Washington State, the COVID-19 hospitalization and case fatality rates were 3.5-fold and 13.6-fold higher, respectively, compared to rates among similarly-aged females and males with SARS-CoV-2 infections in Washington State. One in 11 developed severe or critical disease, 1 in 10 were hospitalized for COVID-19….
Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge
Respiratory, physical, and psychological sequelae were common 3-4 months after hospital discharge in an Italian cohort of COVID-19 survivors (n=238, median age = 61 [IQR 50-71]). 113 of 219 patients (52%) had a significant reduction in lung function measured by diffusing lung capacity for carbon monoxide (80% of expected value), and 128 (54%) patients had…
January 27, 2021
A Higher BMI Is Not Associated with a Different Immune Response and Disease Course in Critically Ill COVID-19 Patients
Among patients with COVID-19 in The Netherlands who required mechanical ventilation in the ICU, higher BMI was not associated with differences in measurements of plasma cytokines or clinical outcomes. Patients (n=67) were classified as obese (BMI ≥30 kg/m2) and non-obese (BMI <30 kg/m2). Obese participants had a lower elevation in body temperature (38.1C vs. 38.7C) but no other clinical…
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