Result for
Topic: Clinical Characteristics and Health Care Setting
December 4, 2020
Balancing Revenue Generation with Capacity Generation: Case Distribution, Financial Impact and Hospital Capacity Changes from Cancelling or Resuming Elective Surgeries in the US during COVID-19
A retrospective cohort analysis of elective surgical case distribution, hospital revenue, and ICU bed capacity during COVID-19 found that in a scenario with 5% infection prevalence, cancelling elective procedures decreased ICU overcapacity from 160 to 130%, but such elective surgical cases contribute 78% (1.1 trillion dollars) to inpatient hospital plus outpatient surgical gross revenue per…
Characteristics of Adults Aged 18–49 Years without Underlying Conditions Hospitalized with Laboratory-Confirmed COVID-19 in the United States, COVID-NET — March–August 2020
Analysis of data from a large, geographically diverse surveillance network of laboratory-confirmed COVID-19 hospitalizations in the US from March-August found that more than 1 in 5 adults (22%) ages 18-49 (n = 513) without underlying conditions who were hospitalized with COVID-19 experienced severe illness requiring ICU-level care. Additionally, 17% required invasive or noninvasive respiratory support,…
Metformin and Risk of Mortality in Patients Hospitalised with COVID-19: A Retrospective Cohort Analysis
Metformin was associated with significantly reduced mortality among women with obesity or type 2 diabetes who were hospitalized with COVID-19, according to a retrospective cohort analysis using de-identified claims data (HR=0.79, 95%CI 0.65–0.95). Metformin use was not associated with a reduction in mortality among men in the study. Bramante et al. (Dec 3, 2020). Metformin…
Patient Outcomes after Hospitalisation with COVID-19 and Implications for Follow-up: Results from a Prospective UK Cohort
A study evaluating patients in the UK (median age 60 years) who had been hospitalized with COVID-19 8-12 weeks after their admission found that most (74%) had persistent symptoms such as breathlessness (39%) and fatigue (39%), and experienced limitations in physical ability. Sixteen (59%) patients in the mild COVID-19 group reported ongoing symptoms compared with…
December 2, 2020
High Anal Swab Viral Load Predisposes Adverse Clinical Outcomes in Severe COVID-19 Patients
Higher viral load of SARS-CoV-2 RNA in anal swab samples was associated with severe COVID-19 outcomes including death (OR=1.4), ICU admission (OR=1.2) and need for invasive mechanical ventilation (OR=1.3) among a cohort of 188 hospitalized COVID-19 patients in China. The period from symptom onset to positive virus detection was also significantly shorter in non-survivors than…
December 1, 2020
Increase in Hospital-Acquired Carbapenem-Resistant Acinetobacter Baumannii Infection and Colonization in an Acute Care Hospital During a Surge in COVID-19 Admissions — New Jersey, February–July 2020
A cluster of 34 patients infected with an antibiotic-resistant pathogen primarily associated with hospital-acquired infections was observed in a New Jersey hospital during a surge of COVID-19 hospitalizations in late May 2020. The cluster was linked to deviations in infection prevention and control practices due to pandemic-related resource challenges. Fewer incident cases were reported in…
Race/Ethnicity Among Children With COVID-19–Associated Multisystem Inflammatory Syndrome
Analysis of routine public health surveillance data from March to June 2020 identified an overrepresentation of Black children among those with COVID-19-associated multi-system inflammatory syndrome in children (MIS-C) in New York City (n=223). While Black children constitute 22% of the New York City population, 34% of patients were Black. Additionally, compared with white children, a…
Second versus First Wave of COVID-19 Deaths Shifts in Age Distribution and in Nursing Home Fatalities
[Pre-print, not peer reviewed] Among 11 countries, the age distribution of COVID-19 deaths was similar in the first and second waves. During the second wave, Western European countries and the US tended to have a larger share of deaths among individuals younger than 50 years old (<45 years old in the US). Among 9 countries…
Maternal Coronavirus Infections and Neonates Born to Mothers with SARS-CoV-2: A Systematic Review
In a systematic review (n=70 studies) including 1,457 pregnant women with COVID-19, 39 newborns tested positive for SARS-CoV-2. Among mothers, the most frequent comorbidities were obesity, hypertensive disorders, and gestational diabetes. Premature birth (n=64) and maternal death (n=15) were the most common adverse maternal outcomes, while intrauterine fetal distress (n=28) and intrauterine fetal death and…
November 30, 2020
A Novel COVID-19 Epidemiological Model with Explicit Susceptible and Asymptomatic Isolation Compartments Reveals Unexpected Consequences of Timing Social Distancing
A modeling study of social distancing mandates on SARS-CoV-2 population dynamics indicated that slight delays in implementing social distance protocols did not have a strong effect on the epidemic curve, but did identify a critical window of approximately two weeks in which to implement a mandate to avoid a substantially larger increase in incidence. The…
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