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Topic: Clinical Characteristics and Health Care Setting
October 26, 2020
Outcomes of COVID-19 Related Hospitalization among People with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): A Prospective Observational Study
HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19 in a study across more than 200 centers in the UK. Individuals presenting to the clinics who were HIV-positive were younger (median 56 versus 74 years) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive…
COVID-19–Associated Hospitalizations Among Health Care Personnel — COVID-NET, 13 States, March 1–May 31, 2020
An analysis of COVID-19 hospitalization data from the US found that 6% of adults hospitalized for COVID-19 were health care professionals, of whom 67% were expected to have direct patient contact and 36% were in nursing-related occupations. 90% of health care professionals hospitalized with COVID-19 had at least one underlying condition, of which obesity (73%),…
Correlates of Death among SARS-CoV-2 Positive Veterans: The Contribution of Lifetime Tobacco Use
Veterans with COVID-19 who reported using tobacco at the time of their illness or at any time prior had a higher risk of mortality, even after controlling for other health and social factors. Other factors positively related to the relative risk of death were older age, male sex, immunodeficiency, and endocrine and pulmonary diseases. Results…
October 23, 2020
SARS CoV-2 Surveillance and Exposure in the Perioperative Setting with Universal Testing and Personal Protective Equipment (PPE) Policies
Universal PCR-based surveillance testing for SARS-CoV-2 before surgeries or procedures at a tertiary care center in New York City identified 65 patients (0.6%) were positive out of 11,540 patients tested. The proportion of tests that were positivity peaked at 4.3% and fell below 0.3% after April 2020. Three of the 65 individuals who tested positive…
Clinical and Epidemiologic Analysis of COVID-19 Children Cases in Colombia PEDIACOVID
At the national level in Colombia, pediatric patients with more severe COVID-19 were significantly younger than those who experienced mild illness or no symptoms. A retrospective analysis found that the mean age of children who had asymptomatic infection was 9.4 years compared to a mean of 4.9 years among those with severe infection and a…
October 22, 2020
Incidence of Health Care–Associated COVID-19 During Universal Testing of Medical and Surgical Admissions in a Large US Health System
Eight cases of possible incident SARS-CoV-2 were observed during hospitalization or within 14 days post-discharge among 2,992 patients who tested negative on admission to UW Medicine (Washington) hospitals between April 2 and May 14. Further review determined 1 to 6 cases as potential hospital-acquired infections, corresponding to a relatively low incidence of 0.8 to 5…
October 21, 2020
Nutritional Risk and Therapy for Severe and Critical COVID-19 Patients: A Multicenter Retrospective Observational Study
Among a cohort of 523 patients hospitalized with COVID-19 from January 2 to February 15, 2020 in China, malnutrition was associated with higher risk of in-hospital death (OR=1.2) and higher risk of poor outcome in the ICU (OR=1.9). After adjustment for age and sex, low BMI and low protein level were also significantly associated with…
October 20, 2020
Prevalence and Clinical Outcomes of COVID-19 in Patients with Autoimmune Diseases: A Systematic Review and Meta-Analysis
A meta-analysis of 7 case-control studies show 2.2-fold higher risk of COVID-19 infection among those with autoimmune diseases. Among the 2,766 patients in studies reporting clinical outcomes, use of glucocorticoids and conventional synthetic disease-modifying antirheumatic drugs were associated with increased risk of hospitalization and mortality. Akiyama et al. (Oct 13, 2020). Prevalence and Clinical Outcomes…
October 19, 2020
Cardiovascular Diseases Burden in COVID-19: Systematic Review and Meta-Analysis
A systematic review and meta-analysis of cardiovascular disease (CVD) and COVID-19 (n=56 studies) identified a high burden of CVD among individuals with COVID-19 and significantly elevated risk for mortality and ICU admission among COVID-19 patients with CVD. Specifically, acute cardiac injury, (OR=13.3), hypertension (OR=2.6), heart failure (OR=6.7), arrhythmia (OR=2.8), coronary artery disease (OR=3.8), and cardiovascular…
Cytokine Elevation in Severe and Critical COVID-19: A Rapid Systematic Review, Meta-Analysis, and Comparison with Other Inflammatory Syndromes
Mean interleukin (IL)-6 concentrations among patients with severe COVID-19 were significantly lower than concentrations found among patients with other critical illnesses associated with elevated cytokine concentrations. A systematic review and meta-analysis compared COVID-19 studies in which IL-6 concentrations in patients with severe or critical disease were recorded with studies of sepsis, cytokine release syndrome, and…
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