Result for
Topic: Clinical Characteristics and Health Care Setting
October 16, 2020
Decreasing Median Age of COVID-19 Cases in the United States—Changing Epidemiology or Changing Surveillance?
A retrospective review of SARS-CoV-2-positive molecular testing results in the US between early (March-April 2020) and later periods (June-July 2020) found a trend toward decreasing age among people with laboratory-confirmed SARS-CoV-2 infection, but that these trends seem to be specific to the outpatient population. In the early period, the median age of individuals testing positive…
Heterogeneity in Testing, Diagnosis and Outcome in SARS-CoV-2 Infection across Outbreak Settings in the Greater Toronto Area, Canada: An Observational Study
A population-based prospective cohort study of residents of long-term care homes, people living in shelters, and members of the general population in Toronto, Canada found that residents of long-term care homes were 2.4 times more likely to test positive for SARS-CoV-2 than the general population and those who received a diagnosis of COVID-19 were 1.4…
October 15, 2020
Healthcare Workers with Mild Asymptomatic SARS-CoV-2 Infection Show T Cell Responses and Neutralising Antibodies after the First Wave
[Pre-print, not peer reviewed] A cohort study of 136 healthcare workers in the UK found that 90% of the 76 workers with mild or asymptomatic SARS-CoV-2 infection had detectable neutralizing antibodies at the beginning of the lockdown and 66% of the same workers had them after 16-18 weeks. T-cell responses tended to be lower among…
Clinical Characteristics Symptoms Management and Health Outcomes in 8598 Pregnant Women Diagnosed with COVID-19 Compared to 27510 with Seasonal Influenza in France Spain and the US
[Pre-print, not peer reviewed] A network cohort analysis of 8,598 pregnant women from France, Spain, and the US with COVID-19 found that women who were eventually hospitalized were more likely to have kidney impairment and anemia. Compared to a cohort of 27,510 pregnant women diagnosed with influenza during the 2017-2018 flu season, pregnant women with…
October 14, 2020
Impact of COVID-19 Mitigation Measures on the Incidence of Preterm Birth: A National Quasi-Experimental Study
Nationwide implementation of COVID-19 mitigation measures in the Netherlands on March 9, 2020 was associated with significant reductions in the incidence of preterm births in the following months compared to the corresponding time window immediately prior to mitigation measures (RR=0.77 to 0.85, depending on the length of the time window on either side of March…
October 12, 2020
Prevalence and Longevity of SARS-CoV-2 Antibodies in Healthcare Workers A Single Center Study
[Pre-print, not peer reviewed]A cross-sectional study to determine the prevalence and longevity of SARS-CoV-2 antibodies in healthcare workers and first responders in California showed that antibody prevalence was 0.9% at the start of the study and 2.6% at 8-week follow-up among healthcare workers, and 5.3% and 4.4%, respectively, among first responders (between May and August,…
Clinical Impact of Molecular Point-of-Care Testing for Suspected COVID-19 in Hospital (COV-19POC): A Prospective, Interventional, Non-Randomised, Controlled Study
Point-of-care testing for SARS-CoV-2 was associated with large reductions in time to results compared with centralized laboratory PCR testing in a prospective, interventional, non-randomized study of molecular point-of-care testing in the UK. 39% of adult patients in the point-of-care testing group and 28% in the control group tested positive for SARS-CoV-2 infection using nose and…
October 9, 2020
SARS-CoV-2 Exposure, Symptoms and Seroprevalence in Healthcare Workers in Sweden
An assessment of the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms, and occupational exposure to SARS-CoV-2 among 2,149 healthcare workers at a hospital in Sweden found that 19% had IgG antibodies against SARS-CoV-2, which was higher than the regional seroprevalence during that time period. Seroprevalence was associated with a loss of smell (OR=28.4), loss of taste…
Neuropathology of Patients with COVID-19 in Germany: A Post-Mortem Case Series
A study of brain tissue from patients who died from COVID-19 indicated that 79% had pronounced neuroinflammatory changes in the brainstem and cerebellum, though in general, neuropathological changes seemed to be mild in most patients. SARS-CoV-2 was detected in 53% of the patients’ brains, and the study found no evidence for central nervous system damage…
Prevalence and Outcome of COVID-19 Infection in Cancer Patients: A National Veterans Affairs Study
The pre-existence of cancer may affects both susceptibility to COVID-19 infection and outcomes, according to an analysis of healthcare records from the US Veterans Affairs healthcare system. The overall COVID-19 attributable mortality in patients with cancer was 10%, which was higher with older age, a higher Charlson comorbidity score, and certain types of cancer. The…
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