Result for
Topic: Clinical Characteristics and Health Care Setting
August 24, 2020
SARS-CoV-2 Infections Among Children in the Biospecimens from Respiratory Virus-Exposed Kids (BRAVE Kids) Study
[pre-print, not peer-reviewed] In a cohort of children and adolescents who had close contact with a person with known SARS-CoV-2 infection (n=382), SARS-CoV-2-infected children (n=293) were more likely to be Hispanic (88% vs 57%), less likely to have asthma (6% vs 17%), and more likely to have an infected sibling contact (49% vs 29%), compared…
August 21, 2020
Is Blood Type Associated with COVID-19 Severity
• [pre-print, not peer-reviewed] After adjusting for socioeconomic status and comorbidities, Mendy et al. found no association between ABO or Rh blood groups and hospitalization or disease severity among 428 people diagnosed with COVID-19 at the University of Cincinnati’s health system. Mendy et al. (Aug 2020). Is Blood Type Associated with COVID-19 Severity? Pre-print downloaded…
August 20, 2020
COVID-19-Associated Critical Illness-Report of the First 300 Patients Admitted to Intensive Care Units at a New York City Medical Center
• Among 300 patients admitted to ICUs at an academic medical center in New York City from March 10 through April 11, 2020, the majority developed acute respiratory distress syndrome requiring mechanical ventilation (91%) and/or vasopressor-dependent shock (78%). Forty-one percent had acute kidney injury (AKI) present upon admission and 36% subsequently developed AKI. The 30-day…
August 19, 2020
Effects of a Major Deletion in the SARS-CoV-2 Genome on the Severity of Infection and the Inflammatory Response: An Observational Cohort Study
Findings from a prospective observational cohort study conducted at seven public hospitals in Singapore show that the 382-nucleotide deletion (∆382) variant of SARS-CoV-2 is associated with a milder infection. Individuals infected with the ∆382 variant were compared with those infected with wild-type SARS-CoV-2. Between January 22 and March 21, among 131 individuals enrolled, 70% were infected with the wild-type virus, 8% had a mix of wild-type and ∆382-variant viruses, and 22% had only…
Allergic Disorders and Susceptibility to and Severity of COVID-19: A Nationwide Cohort Study
In a propensity-score-matched nationwide cohort study (n=219,959) of individuals tested for SARS-CoV-2 in South Korea, patients with allergic rhinitis and asthma were more likely to have a positive SARS-CoV-2 test and to have severe COVID-19 outcomes if infected, compared to individuals without these conditions. The greatest increased risk was among those with non-allergic asthma (for positivity, aOR=1.3, 95%CI 1.1–1.7; for severe disease, aOR=4.1, 95%CI 1.7–10.5). …
SARS-CoV-2 (COVID-19) Infection in Pregnant Women Characterization of Symptoms and Syndromes Predictive of Disease and Severity through Real-Time Remote Participatory Epidemiology
[Pre-print, not peer reviewed] An observational study used a smartphone application and web-based survey to collect self-reported pregnancy status and COVID-19-related symptom information from >400,000 women in the UK and Sweden and >1.3 million reports from women in the US. Investigators found that the profile of SARS-CoV-2 symptom characteristics and severity among pregnant women were comparable to those observed among non-pregnant women, except for gastrointestinal symptoms. Pregnant women were more likely to have received SARS-CoV-2 testing than…
SARS-CoV-2 Infection Among Community Health Workers in India Before and After Use of Face Shields
After the addition of face shields as personal protective equipment, there were no reported infections among the 50 community health workers (CHWs) in India assigned to counsel asymptomatic family contacts of patients who had tested positive for SARS-CoV-2 at their homes. Before implementing face shields, 62 CHWs visited 5,880 homes with 31,164 persons, among whom 222 persons tested positive for SARS-CoV-2 (May 4 to May 13). During this period, 12 CHWs were infected, 8 developed symptoms, and 4 were…
August 18, 2020
Longitudinal SARS-CoV-2 Serosurveillance of over Ten Thousand Health Care Workers in the Providence Oregon Cohort
[Pre-print, not peer reviewed] A large serosurveillance study (n=10,019) of asymptomatic healthcare workers across Oregon found 2.5% (n=253) had antibodies against SARS-CoV-2. The highest seroprevalence was found among those with a job type of housekeeper (8%). Comparing self-reported swab PCR testing with serology results showed only modest agreement (K=0.47). Leidner et al. (Aug 18, 2020). Longitudinal SARS-CoV-2 Serosurveillance of over Ten Thousand Health Care Workers in…
Coronavirus 2019 (COVID-19) Infections Among Healthcare Workers, Los Angeles County, February – May 2020
Among COVID-19 positive healthcare workers in Los Angeles County (n=5,118), Hartmann et al. found that the highest proportion worked in long-term care facilities (46%) and hospitals (28%). Sixty-eight percent worked at some point during their infectious period, while nearly half reported a known exposure to a positive patient and/or co-worker. Compared to the general population, healthcare workers reported…
Maternal and Neonatal Characteristics and Outcomes among COVID-19 Infected Women: An Updated Systematic Review and Meta-Analysis
A systematic review including 61 studies comprising 790 COVID-19 positive females and 548 neonates found that C-section, premature birth, and adverse pregnancy events varied geographically among women with COVID-19. C-section prevalence ranged from 38% in European studies to 91% in Chinese studies, while adverse pregnancy event prevalence ranged from 15% in US studies to 21% in Chinese studies. …
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